VPS38_SCHPO
ID VPS38_SCHPO Reviewed; 474 AA.
AC O60149;
DT 05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 16-MAY-2012, sequence version 2.
DT 25-MAY-2022, entry version 104.
DE RecName: Full=Vacuolar protein sorting-associated protein 38;
GN Name=vps38; ORFNames=SPBC18H10.19;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP REVISION OF GENE MODEL.
RX PubMed=21511999; DOI=10.1126/science.1203357;
RA Rhind N., Chen Z., Yassour M., Thompson D.A., Haas B.J., Habib N.,
RA Wapinski I., Roy S., Lin M.F., Heiman D.I., Young S.K., Furuya K., Guo Y.,
RA Pidoux A., Chen H.M., Robbertse B., Goldberg J.M., Aoki K., Bayne E.H.,
RA Berlin A.M., Desjardins C.A., Dobbs E., Dukaj L., Fan L., FitzGerald M.G.,
RA French C., Gujja S., Hansen K., Keifenheim D., Levin J.Z., Mosher R.A.,
RA Mueller C.A., Pfiffner J., Priest M., Russ C., Smialowska A., Swoboda P.,
RA Sykes S.M., Vaughn M., Vengrova S., Yoder R., Zeng Q., Allshire R.,
RA Baulcombe D., Birren B.W., Brown W., Ekwall K., Kellis M., Leatherwood J.,
RA Levin H., Margalit H., Martienssen R., Nieduszynski C.A., Spatafora J.W.,
RA Friedman N., Dalgaard J.Z., Baumann P., Niki H., Regev A., Nusbaum C.;
RT "Comparative functional genomics of the fission yeasts.";
RL Science 332:930-936(2011).
RN [3]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
RN [4]
RP IDENTIFICATION.
RX PubMed=23950735; DOI=10.1371/journal.pgen.1003715;
RA Sun L.L., Li M., Suo F., Liu X.M., Shen E.Z., Yang B., Dong M.Q., He W.Z.,
RA Du L.L.;
RT "Global analysis of fission yeast mating genes reveals new autophagy
RT factors.";
RL PLoS Genet. 9:E1003715-E1003715(2013).
CC -!- FUNCTION: Involved in endosome-to-Golgi retrograde transport as part of
CC the vps34 PI3-kinase complex II. Mediates the interaction between atg6
CC and the pik3-ppk19 core complex, leading to the recruitment of atg6 to
CC the membrane (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Component of the vps34 PI3-kinase complex II composed of
CC ppk19/vps15, atg6, pik3/vps34 and vps38. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16823372}. Golgi
CC apparatus, trans-Golgi network membrane {ECO:0000250}; Peripheral
CC membrane protein {ECO:0000250}. Endosome membrane {ECO:0000250};
CC Peripheral membrane protein {ECO:0000250}.
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DR EMBL; CU329671; CAA18416.2; -; Genomic_DNA.
DR PIR; T39783; T39783.
DR RefSeq; NP_595743.2; NM_001021641.2.
DR AlphaFoldDB; O60149; -.
DR SMR; O60149; -.
DR BioGRID; 277354; 77.
DR STRING; 4896.SPBC18H10.19.1; -.
DR MaxQB; O60149; -.
DR PaxDb; O60149; -.
DR EnsemblFungi; SPBC18H10.19.1; SPBC18H10.19.1:pep; SPBC18H10.19.
DR GeneID; 2540836; -.
DR KEGG; spo:SPBC18H10.19; -.
DR PomBase; SPBC18H10.19; vps38.
DR VEuPathDB; FungiDB:SPBC18H10.19; -.
DR eggNOG; KOG2896; Eukaryota.
DR HOGENOM; CLU_588145_0_0_1; -.
DR InParanoid; O60149; -.
DR OMA; MADTWFS; -.
DR Reactome; R-SPO-1632852; Macroautophagy.
DR PRO; PR:O60149; -.
DR Proteomes; UP000002485; Chromosome II.
DR GO; GO:0005829; C:cytosol; HDA:PomBase.
DR GO; GO:0005768; C:endosome; IBA:GO_Central.
DR GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0000329; C:fungal-type vacuole membrane; ISO:PomBase.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR GO; GO:0000323; C:lytic vacuole; IBA:GO_Central.
DR GO; GO:0034272; C:phosphatidylinositol 3-kinase complex, class III, type II; IDA:PomBase.
DR GO; GO:0000149; F:SNARE binding; IBA:GO_Central.
DR GO; GO:0045324; P:late endosome to vacuole transport; ISO:PomBase.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0035493; P:SNARE complex assembly; IBA:GO_Central.
DR InterPro; IPR018791; UV_resistance/autophagy_Atg14.
DR Pfam; PF10186; ATG14; 1.
PE 3: Inferred from homology;
KW Coiled coil; Cytoplasm; Endosome; Golgi apparatus; Membrane;
KW Protein transport; Reference proteome; Transport.
FT CHAIN 1..474
FT /note="Vacuolar protein sorting-associated protein 38"
FT /id="PRO_0000372371"
FT COILED 271..300
FT /evidence="ECO:0000255"
SQ SEQUENCE 474 AA; 55498 MW; D77396EED0F4B1AD CRC64;
MSLELPGNYR LSRLKSIQIR NVQEIQNHSK FAINTTENLW KRDVQLKRAI SEGTIRIFIS
LHVQSKKLPV YITETSGNAN HIFYVDEKVT EKLQKYRHEE YFIVRTWCSS SSHAFKLHKE
WKILRYDSNF RYIGNDPVFA VCHIRNGLLC EFNDGVYIYT TSQSSDIMRQ TSFPKSASTY
SIDRRKDGYT IQKITRILKL AECIDEMHIA KHEIRAHFQE EEFQQIRLMH KRMLLRDEKI
DELAKLEHLW QKQINSITQM RTKFDKTKSW LSSKRNTLNK SKESLQKDEA EYVELANSLK
TKVETNIEIR ILMAHAIRMH VSHLSKIYPI QPSPGNHDEF TIRNLRLSFE PDKINNVEMA
ASIGFLAHLL QTLSKYLEKE LAYPILCASS RSSILDTLTP DIPTRIFPLY PATRPIELFE
HAIYLLNQDV NDFLETFGLP IDQSMDILRN FKKLLQFILS GQHLSFVQVT STAP
