VPS3_SCHPO
ID VPS3_SCHPO Reviewed; 910 AA.
AC O59796;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1999, sequence version 2.
DT 25-MAY-2022, entry version 106.
DE RecName: Full=Vacuolar protein sorting-associated protein 3;
GN Name=vps3; ORFNames=SPCC364.05;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
CC -!- FUNCTION: Required for sorting and processing of soluble vacuolar
CC proteins. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the VPS3 family. {ECO:0000305}.
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DR EMBL; CU329672; CAA18287.1; -; Genomic_DNA.
DR PIR; T41331; T41331.
DR RefSeq; NP_587839.1; NM_001022832.2.
DR AlphaFoldDB; O59796; -.
DR BioGRID; 276081; 62.
DR STRING; 4896.SPCC364.05.1; -.
DR MaxQB; O59796; -.
DR PaxDb; O59796; -.
DR EnsemblFungi; SPCC364.05.1; SPCC364.05.1:pep; SPCC364.05.
DR GeneID; 2539519; -.
DR KEGG; spo:SPCC364.05; -.
DR PomBase; SPCC364.05; vps3.
DR VEuPathDB; FungiDB:SPCC364.05; -.
DR eggNOG; KOG2063; Eukaryota.
DR HOGENOM; CLU_314265_0_0_1; -.
DR InParanoid; O59796; -.
DR OMA; NAYIMLM; -.
DR PhylomeDB; O59796; -.
DR PRO; PR:O59796; -.
DR Proteomes; UP000002485; Chromosome III.
DR GO; GO:0033263; C:CORVET complex; ISO:PomBase.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005829; C:cytosol; HDA:PomBase.
DR GO; GO:0000329; C:fungal-type vacuole membrane; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; HDA:PomBase.
DR GO; GO:0006914; P:autophagy; IBA:GO_Central.
DR GO; GO:0034058; P:endosomal vesicle fusion; IBA:GO_Central.
DR GO; GO:0006886; P:intracellular protein transport; IC:PomBase.
DR GO; GO:0045324; P:late endosome to vacuole transport; IC:PomBase.
DR InterPro; IPR001180; CNH_dom.
DR InterPro; IPR032914; Vam6/VPS39/TRAP1.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR12894; PTHR12894; 2.
DR Pfam; PF00780; CNH; 1.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS50219; CNH; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Protein transport; Reference proteome; Repeat; TPR repeat;
KW Transport.
FT CHAIN 1..910
FT /note="Vacuolar protein sorting-associated protein 3"
FT /id="PRO_0000314772"
FT DOMAIN 16..288
FT /note="CNH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00795"
FT REPEAT 69..101
FT /note="TPR 1"
FT REPEAT 383..416
FT /note="TPR 2"
FT REPEAT 554..587
FT /note="TPR 3"
FT REPEAT 674..710
FT /note="TPR 4"
FT REPEAT 712..743
FT /note="TPR 5"
FT REPEAT 763..797
FT /note="TPR 6"
SQ SEQUENCE 910 AA; 104581 MW; 872BD0522994D5B4 CRC64;
MSDIELHESA IPKELDSPVT TIALYNNHLY FGTEGGDVFL YNFSNFQLNE SPELVKKISL
VSKSRVNRIL AMPFLGAVFI HHGSFAEVYK EDDLTQLYPS ISFKGLVEFC HPGQRIDEKS
TYLIVTNTHL KLISFQKDGI ILVKNELKYP NIQTARVNGH IVCLVTENSF ELLDILTFDT
TPLFPIIKYD SENNGLMYKP MIVLHSNEFL LITGSPKDAI GLFVDSQGNV TRSTLTFSFY
PKHVFSTSHY VFAISSSSLQ IIDINTLSLV KSINLKDDES FSFISRLTSV HFCDRQIFSK
FSAVNTASTS KTSDTIERAS FSKPSFIFLT NKSWGFGAEA HFMNKLEFSI TIGDIEAPLR
RVSKRLRNPK KYGITNDVAY LQSAYLEQIS ALQYWKQGQY ENSLSLLETS KIDPRVVISL
YPDLYHSELS YIAFQGVISF RKSILSVDDT VANVLKSNEL FRDTDQYTQR QMIEITKENA
YIMLMRYLKN YKKNTSISEY LLSSQRDVML AVEHSLLLLY LNMDDLAAGT KNAKELLESG
LTGVEDIKDV LIQKKEYYLL SVLLATVRDH DGVLQTWKKL ITGDYEDRRF NDGLIKIREY
LVNDIEPSTF WEFTTWLCKH DATEGTRVLL DKTVSGSISA EDVLEHLDSS QDDVLIDYLV
KSNSVTHRAL LLKLCVNKLL GSLLDHNDFK NRLETAIETF RELPCMEKPT YAQYLEQLWG
DMSDFSTHLS FYYLCSINLM ENVEEESIDK IKDILFDIHV DNLYLFPQLE HSFYKRKKNY
EKALSVLVTN IHDYKGGEAY CLQIDDVYPQ CWCNLLEKCI STGDGCSDFI KELLYRRPFS
YTLSYVCEQI PDHWNLNLLA DFLCILQKRN AERLNESQTR LTLEKSLSQN LEELFMAINR
RNVALGKNEI
