ID   VPS41_SCHPO             Reviewed;         871 AA.
AC   Q9P7N3;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   13-JUN-2012, sequence version 2.
DT   25-MAY-2022, entry version 121.
DE   RecName: Full=Vacuolar protein sorting-associated protein 41;
GN   Name=vps41; ORFNames=SPAP27G11.05c;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
RN   [2]
RP   REVISION OF GENE MODEL.
RX   PubMed=21511999; DOI=10.1126/science.1203357;
RA   Rhind N., Chen Z., Yassour M., Thompson D.A., Haas B.J., Habib N.,
RA   Wapinski I., Roy S., Lin M.F., Heiman D.I., Young S.K., Furuya K., Guo Y.,
RA   Pidoux A., Chen H.M., Robbertse B., Goldberg J.M., Aoki K., Bayne E.H.,
RA   Berlin A.M., Desjardins C.A., Dobbs E., Dukaj L., Fan L., FitzGerald M.G.,
RA   French C., Gujja S., Hansen K., Keifenheim D., Levin J.Z., Mosher R.A.,
RA   Mueller C.A., Pfiffner J., Priest M., Russ C., Smialowska A., Swoboda P.,
RA   Sykes S.M., Vaughn M., Vengrova S., Yoder R., Zeng Q., Allshire R.,
RA   Baulcombe D., Birren B.W., Brown W., Ekwall K., Kellis M., Leatherwood J.,
RA   Levin H., Margalit H., Martienssen R., Nieduszynski C.A., Spatafora J.W.,
RA   Friedman N., Dalgaard J.Z., Baumann P., Niki H., Regev A., Nusbaum C.;
RT   "Comparative functional genomics of the fission yeasts.";
RL   Science 332:930-936(2011).
CC   -!- FUNCTION: Required for vacuolar assembly and vacuolar traffic.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the VPS41 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CU329670; CAB76026.2; -; Genomic_DNA.
DR   RefSeq; NP_593409.2; NM_001018842.2.
DR   AlphaFoldDB; Q9P7N3; -.
DR   SMR; Q9P7N3; -.
DR   STRING; 4896.SPAP27G11.05c.1; -.
DR   iPTMnet; Q9P7N3; -.
DR   MaxQB; Q9P7N3; -.
DR   PaxDb; Q9P7N3; -.
DR   PRIDE; Q9P7N3; -.
DR   EnsemblFungi; SPAP27G11.05c.1; SPAP27G11.05c.1:pep; SPAP27G11.05c.
DR   GeneID; 2542058; -.
DR   KEGG; spo:SPAP27G11.05c; -.
DR   PomBase; SPAP27G11.05c; vps41.
DR   VEuPathDB; FungiDB:SPAP27G11.05c; -.
DR   eggNOG; KOG2066; Eukaryota.
DR   HOGENOM; CLU_001285_2_2_1; -.
DR   InParanoid; Q9P7N3; -.
DR   OMA; KFKYQRI; -.
DR   PRO; PR:Q9P7N3; -.
DR   Proteomes; UP000002485; Chromosome I.
DR   GO; GO:0005737; C:cytoplasm; HDA:PomBase.
DR   GO; GO:0005829; C:cytosol; IEA:GOC.
DR   GO; GO:0030897; C:HOPS complex; IBA:GO_Central.
DR   GO; GO:0005770; C:late endosome; IBA:GO_Central.
DR   GO; GO:1902500; C:vacuolar HOPS complex; ISS:PomBase.
DR   GO; GO:0009267; P:cellular response to starvation; IBA:GO_Central.
DR   GO; GO:0034058; P:endosomal vesicle fusion; IBA:GO_Central.
DR   GO; GO:0006895; P:Golgi to endosome transport; ISS:PomBase.
DR   GO; GO:0045324; P:late endosome to vacuole transport; ISS:PomBase.
DR   GO; GO:0016236; P:macroautophagy; IBA:GO_Central.
DR   GO; GO:0006623; P:protein targeting to vacuole; ISS:PomBase.
DR   GO; GO:0042144; P:vacuole fusion, non-autophagic; ISS:PomBase.
DR   GO; GO:0048278; P:vesicle docking; ISS:PomBase.
DR   Gene3D; 1.25.40.10; -; 1.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR000547; Clathrin_H-chain/VPS_repeat.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR016902; VPS41.
DR   InterPro; IPR045111; Vps41/Vps8.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR12616; PTHR12616; 1.
DR   Pfam; PF00637; Clathrin; 1.
DR   PIRSF; PIRSF028921; VPS41; 1.
DR   SMART; SM00299; CLH; 1.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS50236; CHCR; 1.
PE   3: Inferred from homology;
KW   Protein transport; Reference proteome; Repeat; Transport; WD repeat.
FT   CHAIN           1..871
FT                   /note="Vacuolar protein sorting-associated protein 41"
FT                   /id="PRO_0000314101"
FT   REPEAT          39..76
FT                   /note="WD 1"
FT   REPEAT          78..117
FT                   /note="WD 2"
FT   REPEAT          119..162
FT                   /note="WD 3"
FT   REPEAT          166..204
FT                   /note="WD 4"
FT   REPEAT          575..716
FT                   /note="CHCR"
FT   REGION          1..23
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   871 AA;  100267 MW;  1EF53D1228BDE5D2 CRC64;
     MSVDESNSDS EIDSISSSDE DEEPKLIYER ITEKFQGCFM NDTISACAIS KEHFFFGSHN
     GAIYIYQKNG ILLRKMILHS ASVVDLSVDL ESENLASCSM DGKMIISNIT TRETTVHDFK
     RPLLSVAIDP YYSTRSSRQV LSGGRAGKVV LSEKGWLGNK DTVLQADCGA VYKISWYTTY
     IAWASDLGIT VYSTEFGKVL GRLEPPKRLP NDEIFPYQLF WQSESRLVIG WSDQIMIVSI
     QRSNVANELP KISLQALLEI DSIVSGVLML GFNILTLAYI ANVEDFTSAI PSQRIEGCRP
     ELRLIDSSFK ELCGDAIGLA NYSRLQPSDY HLLPDPSSNS HSFVISPNDI VYVRERNQID
     HVKYLVSKEM YAEAIDAVKK LPEIPPSLQI SELAKKYIFH LLGKGQYKEA GMVIPSLYND
     NLAEWEQWVF VFAENDHLED IADFLPTGEN HLSPLVYEMI LAQYLATDER TFNKKLHEWP
     TMLYSVSTIR NATLKKFKEN QKSSTLTESL AFLYLEDNMP IDAFHLYLKL HSELCIDLIL
     QHNLYDEARA SVLLLMLISS KGKSSDTKSA MSSMLVQHVH SFPPQEVIMQ IHSVPQFLYE
     YFCEFELMYP NSLMEYGDLK LDVFAEFDRK RFFDFLVNTQ CYSLDHAAQI CKQYNYLDEL
     VYILGRMGNN KEALMLIINE LLDIGRAIRY VKEQADRELW DDLISYSLDK PEFICTLLEN
     IGTDENARNL LSKIPPGTKL PHMKKSISKL LADHQSQVQL YQSCYKLFKN ESISMAIKYR
     EQEQSGLEFL VKDNPFNSFG DEQLDYNYRK RIPMIYDLRT KKYIRPEDVR IDTDDVFKDD
     KIAYFKTRMH LKPEVQMRNK LDLLMMLYKQ T