ID   VPS41_SOLLC             Reviewed;         960 AA.
AC   P93231;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1997, sequence version 1.
DT   03-AUG-2022, entry version 116.
DE   RecName: Full=Vacuolar protein sorting-associated protein 41 homolog;
GN   Name=VPS41;
OS   Solanum lycopersicum (Tomato) (Lycopersicon esculentum).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   asterids; lamiids; Solanales; Solanaceae; Solanoideae; Solaneae; Solanum;
OC   Solanum subgen. Lycopersicon.
OX   NCBI_TaxID=4081;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=9159129; DOI=10.1073/pnas.94.11.5662;
RA   Radisky D.C., Snyder W.B., Emr S.D., Kaplan J.;
RT   "Characterization of VPS41, a gene required for vacuolar trafficking and
RT   high-affinity iron transport in yeast.";
RL   Proc. Natl. Acad. Sci. U.S.A. 94:5662-5666(1997).
CC   -!- FUNCTION: Required for vacuolar assembly and vacuolar traffic.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the VPS41 family. {ECO:0000305}.
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DR   EMBL; U86662; AAB60857.1; -; mRNA.
DR   PIR; T07680; T07680.
DR   RefSeq; NP_001233981.1; NM_001247052.1.
DR   AlphaFoldDB; P93231; -.
DR   SMR; P93231; -.
DR   STRING; 4081.Solyc06g074740.2.1; -.
DR   PaxDb; P93231; -.
DR   PRIDE; P93231; -.
DR   EnsemblPlants; Solyc06g074740.3.1; Solyc06g074740.3.1; Solyc06g074740.3.
DR   GeneID; 544040; -.
DR   Gramene; Solyc06g074740.3.1; Solyc06g074740.3.1; Solyc06g074740.3.
DR   KEGG; sly:544040; -.
DR   eggNOG; KOG2066; Eukaryota.
DR   HOGENOM; CLU_001285_2_2_1; -.
DR   InParanoid; P93231; -.
DR   OMA; KFKYQRI; -.
DR   OrthoDB; 722805at2759; -.
DR   PhylomeDB; P93231; -.
DR   Proteomes; UP000004994; Chromosome 6.
DR   GO; GO:0030897; C:HOPS complex; IBA:GO_Central.
DR   GO; GO:0005770; C:late endosome; IBA:GO_Central.
DR   GO; GO:0009267; P:cellular response to starvation; IBA:GO_Central.
DR   GO; GO:0034058; P:endosomal vesicle fusion; IBA:GO_Central.
DR   GO; GO:0016236; P:macroautophagy; IBA:GO_Central.
DR   GO; GO:0006623; P:protein targeting to vacuole; IBA:GO_Central.
DR   Gene3D; 1.25.40.10; -; 1.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR000547; Clathrin_H-chain/VPS_repeat.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR016902; VPS41.
DR   InterPro; IPR045111; Vps41/Vps8.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR12616; PTHR12616; 1.
DR   Pfam; PF00637; Clathrin; 1.
DR   PIRSF; PIRSF028921; VPS41; 1.
DR   SMART; SM00299; CLH; 1.
DR   SMART; SM00320; WD40; 2.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS50236; CHCR; 1.
PE   2: Evidence at transcript level;
KW   Protein transport; Reference proteome; Repeat; Transport; WD repeat.
FT   CHAIN           1..960
FT                   /note="Vacuolar protein sorting-associated protein 41
FT                   homolog"
FT                   /id="PRO_0000212826"
FT   REPEAT          90..132
FT                   /note="WD 1"
FT   REPEAT          178..214
FT                   /note="WD 2"
FT   REPEAT          607..754
FT                   /note="CHCR"
FT   REGION          1..39
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          917..948
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        12..34
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        925..943
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   960 AA;  107886 MW;  6679D8A6A495C3DE CRC64;
     MSPKPSENGI DGDDERDEEE EDSEEEEAEE EEEDEPRLKY QRMGASVPSL LSADAATCIA
     VAERMIALGT HGGAVHILDF LGNQVKEFAA HTAAVNDLCF DTDGEYVGSC SDDGSVVINS
     LFTDERMKFE YHRPMKAIAL DPDYARTSSR RFVTGGLAGQ LYLNVKKWLG YRDQVLHSGE
     GPIHAVKWRT SLVAWANDTG VKVYDASNDQ RITFIERPRG IPRPELLLPH IVWQDDSLLV
     IGWGTSVKIA LIRTTQSKGA NGTYKHMSMS SLNQVDIVAS FQTSYFISGI APFGDSLVIL
     AYIPGEEDGE KDFSSTIPSR QGNAQRPEVR VVTWNNDELA TDALPVHGFE HYKAKDYSLA
     HAPFSGSSYA GGQWAAGDEP LYYIVSPKDV VIAKPRDAED HINWLLQHGW HEKALEAVEA
     NQGQSELLDE VGSRYLDHLI VERKYAEAAS LCPKLLRGSA SAWERWVFHF AHLRQLPVLV
     PYIPTENPRL RDTAYEVALV ALATNPSFHK DLLSTVKSWP PRIYSTTPVF SAIEPQINTS
     SMTDPLKEAL AELYVIDGQH DKAFALYADL MKPDLFDFIE KHNLHDAVRE KVLQLMMIDC
     KRAVLLLIQQ RDLIPPSEVV SQLIAARDKC DYRYFLHLYL HSLFEVNLHA GKDYHDMQVE
     LYADYDPKML LTFLRSSQHY TLEKAYEICV KKDLLKEQVF ILGRMGNAKQ ALAVIINRLG
     DIEEAIEFVS MQQDDELWEE LIQQSFHKPE MVGVLLEHTV GNLDPLYIVN MLPNDLEIPR
     LRDRLVKIVT DYRTETSLRH GCNDILKADC VNLLVKYYKE AKRGVCLSDE VDDVSSRRGE
     KSVSHLGERT MSLKSVEVKS KTRGGGRCCI CFDPFSILNV SIIAFFCCHA YHTTCLMESS
     ISVGGKKEAG VAAQRTTSYD EYPNGVNDDY EDEDEEEEEE EDATSGALPM RCILCTTAAG