ID   VPS51_DICDI             Reviewed;         917 AA.
AC   Q54KG3;
DT   16-DEC-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 81.
DE   RecName: Full=Vacuolar protein sorting-associated protein 51 homolog;
DE   AltName: Full=Protein fat-free homolog;
GN   Name=vps51; Synonyms=ffr; ORFNames=DDB_G0287445;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: May act as component of the GARP complex that is involved in
CC       retrograde transport from early and late endosomes to the trans-Golgi
CC       network (TGN). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the Golgi-associated retrograde protein (GARP)
CC       complex. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the VPS51 family. {ECO:0000305}.
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DR   EMBL; AAFI02000100; EAL63790.1; -; Genomic_DNA.
DR   RefSeq; XP_637260.1; XM_632168.1.
DR   AlphaFoldDB; Q54KG3; -.
DR   SMR; Q54KG3; -.
DR   STRING; 44689.DDB0233907; -.
DR   PaxDb; Q54KG3; -.
DR   EnsemblProtists; EAL63790; EAL63790; DDB_G0287445.
DR   GeneID; 8626090; -.
DR   KEGG; ddi:DDB_G0287445; -.
DR   dictyBase; DDB_G0287445; -.
DR   eggNOG; KOG2346; Eukaryota.
DR   HOGENOM; CLU_020677_0_0_1; -.
DR   InParanoid; Q54KG3; -.
DR   OMA; HTIEPRT; -.
DR   PhylomeDB; Q54KG3; -.
DR   PRO; PR:Q54KG3; -.
DR   Proteomes; UP000002195; Chromosome 5.
DR   GO; GO:0005829; C:cytosol; IEA:GOC.
DR   GO; GO:1990745; C:EARP complex; IBA:GO_Central.
DR   GO; GO:0000938; C:GARP complex; IBA:GO_Central.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   GO; GO:0032456; P:endocytic recycling; IBA:GO_Central.
DR   GO; GO:0007030; P:Golgi organization; IBA:GO_Central.
DR   GO; GO:0048193; P:Golgi vesicle transport; IBA:GO_Central.
DR   GO; GO:0007041; P:lysosomal transport; IBA:GO_Central.
DR   GO; GO:0042147; P:retrograde transport, endosome to Golgi; IBA:GO_Central.
DR   InterPro; IPR016159; Cullin_repeat-like_dom_sf.
DR   InterPro; IPR014812; Vps51.
DR   PANTHER; PTHR15954; PTHR15954; 1.
DR   SUPFAM; SSF74788; SSF74788; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Reference proteome.
FT   CHAIN           1..917
FT                   /note="Vacuolar protein sorting-associated protein 51
FT                   homolog"
FT                   /id="PRO_0000356838"
FT   REGION          94..151
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          760..805
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          229..259
FT                   /evidence="ECO:0000255"
FT   COILED          524..547
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        94..147
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        768..805
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   917 AA;  103808 MW;  9F40D2072304C8E2 CRC64;
     MSQSISDIKL VKFYYRHYKL GPQDFCREYG GNVDGLNKFL TGNYDSLAAR DALRSFWERF
     NTNQLMKSQA GDEDDGDEFN STFGGGDSML LSPIKVTSPM SSSSSSTNTT NSNGQIIGNR
     SFSSLAEATS NATTTTTSTT TTGGKPESKR VRNLLKTYYG PGIGEGSDSS SMNDPLNIDG
     PSFNLNSYFD SIVKSSTLNQ LIQKDNQMVS EIRTLDGDMK TLVYDNYTKF INATDIIKKM
     KTNVENMEEG MALLSKNMDL ITNCSEKINS TLSVRRDRID QLSGLQKFFQ KLQFLTALPS
     SLNHCLAMQA YNQAVRYYNS NSGILKQYSH IPSFQNIQNE CDSIMKTMKD KLYERLSSLS
     TSQTDCVESA EVLMDLLEPV ELVRSKYLES RKHHTITLLE NLEKKSVEHI TDYIKELNAN
     FLSEYSYNIT SYKSLFINRL DGSDSKKERQ QSLLQLEDFS KDLFNKYLNI AKSKLSSFKD
     PIEKIMALEI INSDVSRLGS ELSSHEKITN IINSTVHDQI DFYFDNLQKT IKEHIHQLNS
     TLNERRDEVL EGHNLQELSD ATSKAIVNDI ILLFANLKPF FLPTETQFLS SYQDTIFTKI
     QVKLQQFFLF LVNIHFLEYL DIIATTSNRE QFSGRFLLVL SSICLYFENK GITLVVQLMS
     EFITVAKQGA KKELNVFSFN APDLCKRVRE TGLQILNVFT RLSSQKLDKI LKKGLESIPN
     NNWLVLKEPR DVRSVNDIYL EEILKFQNET SKLLPVINHH HHSLKSHSRT GSGGNSVSSN
     NSSSNTPDGH RRNPSASSSS SSNNTNTTLF EKKVDHVDFN TLSVLIAIIK LSLKSFNESL
     RLKTFGTNGC HQIQIDLHYL KLSLYDLFGS NSFDNLLQEC ENTVTERCVD PLPLAKSIVS
     KICETKMNKK KNNEAES