VPS51_DROME
ID VPS51_DROME Reviewed; 740 AA.
AC Q8MSY4; Q9V8L5;
DT 20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 133.
DE RecName: Full=Vacuolar protein sorting-associated protein 51 homolog;
DE AltName: Full=Protein fat-free homolog;
GN Name=Vps51 {ECO:0000312|FlyBase:FBgn0034380};
GN ORFNames=CG15087 {ECO:0000312|FlyBase:FBgn0034380};
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Embryo;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
CC -!- FUNCTION: May act as a component of the GARP complex that is involved
CC in retrograde transport from early and late endosomes to the trans-
CC Golgi network (TGN). {ECO:0000250}.
CC -!- SUBUNIT: Component of the Golgi-associated retrograde protein (GARP)
CC complex. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the VPS51 family. {ECO:0000305}.
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DR EMBL; AE013599; AAF57649.3; -; Genomic_DNA.
DR EMBL; AY118494; AAM49863.1; -; mRNA.
DR RefSeq; NP_611363.2; NM_137519.3.
DR AlphaFoldDB; Q8MSY4; -.
DR SMR; Q8MSY4; -.
DR BioGRID; 62828; 10.
DR IntAct; Q8MSY4; 7.
DR STRING; 7227.FBpp0085829; -.
DR PaxDb; Q8MSY4; -.
DR PRIDE; Q8MSY4; -.
DR DNASU; 37156; -.
DR EnsemblMetazoa; FBtr0086647; FBpp0085829; FBgn0034380.
DR GeneID; 37156; -.
DR KEGG; dme:Dmel_CG15087; -.
DR UCSC; CG15087-RA; d. melanogaster.
DR CTD; 738; -.
DR FlyBase; FBgn0034380; Vps51.
DR VEuPathDB; VectorBase:FBgn0034380; -.
DR eggNOG; KOG2346; Eukaryota.
DR GeneTree; ENSGT00390000001738; -.
DR HOGENOM; CLU_020677_0_0_1; -.
DR InParanoid; Q8MSY4; -.
DR OMA; HTIEPRT; -.
DR OrthoDB; 1305393at2759; -.
DR PhylomeDB; Q8MSY4; -.
DR BioGRID-ORCS; 37156; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 37156; -.
DR PRO; PR:Q8MSY4; -.
DR Proteomes; UP000000803; Chromosome 2R.
DR Bgee; FBgn0034380; Expressed in egg cell and 25 other tissues.
DR Genevisible; Q8MSY4; DM.
DR GO; GO:0005829; C:cytosol; IEA:GOC.
DR GO; GO:1990745; C:EARP complex; IBA:GO_Central.
DR GO; GO:0000938; C:GARP complex; ISS:FlyBase.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0032456; P:endocytic recycling; ISS:FlyBase.
DR GO; GO:0007030; P:Golgi organization; IBA:GO_Central.
DR GO; GO:0048193; P:Golgi vesicle transport; IBA:GO_Central.
DR GO; GO:0007041; P:lysosomal transport; IBA:GO_Central.
DR GO; GO:0042147; P:retrograde transport, endosome to Golgi; IBA:GO_Central.
DR InterPro; IPR016159; Cullin_repeat-like_dom_sf.
DR InterPro; IPR014812; Vps51.
DR PANTHER; PTHR15954; PTHR15954; 1.
DR SUPFAM; SSF74788; SSF74788; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; Reference proteome.
FT CHAIN 1..740
FT /note="Vacuolar protein sorting-associated protein 51
FT homolog"
FT /id="PRO_0000361544"
FT COILED 65..87
FT /evidence="ECO:0000255"
FT COILED 322..344
FT /evidence="ECO:0000255"
SQ SEQUENCE 740 AA; 83938 MW; 10F38BF39974A623 CRC64;
MAETKANPFD MDSSSFDAEK YLERLLKDCS LKQIMDTEAA VVKDTQTLHS DMQTLVYENY
NKFISATDTI RRMKDDFKQM ETDVNLLMTK MQSITTFSEQ ITGTLQGTRS QLCRLSEKHS
LLKRLQFLST LPAKLKSLIE EQNYAQAVQD YLHAQKVFAQ YGRQPSFDGI QRDCDAIMAD
LKEQLRSDFQ RAGNTAQSLT EIGELLLQLD EKTSDLASEM LTCAGKRLHE QIVMLQDQTE
RDMLEFVDMG IDGFLNDLAL VVTSYFDMFV AKHYEHERDD FQENALQELN VFLNQNIEKY
LTLVQDRVES DIGYGDTQVM LRALDRLHRR LQAMRNICRG LEVQRNTVSI IISAAHQLCD
AHAKNLKDHF ADSLSAVRLS LVSAKSDAAA GLNLGDLISN LYVSMVEKIK GVLQDLLIFL
RTDWSFNIKA EHKGALCVEG IRENLLIGFL RHIAKVMCGF GDASSSSPPN LLLVLSKTCL
ELEQQGVHIL IALVDDLYEI DSENSATLTH ETEICAEMRE TAQSLLDAYV RLQGTNISQM
LRKSVETRDW LNCLEPRSVR AVMKRVVEEL GSIETVVASL YEANTNATSG FRTTASSDSS
RKTYFSNFAS TSKPQYRSNW SNYTPSQLES SYVSNIHRLF SERVEIFTSV EFTKASIIMG
IIKIGLKTLL ECVRLRTFSK FGLQQIQVDA HYLQMNLWRF VSDENLVNFL LDEILGSAVQ
RCLESVLMEP NAVEIICERG
