ID   VPS51_XENLA             Reviewed;         757 AA.
AC   Q505L3;
DT   20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT   07-JUN-2005, sequence version 1.
DT   03-AUG-2022, entry version 53.
DE   RecName: Full=Vacuolar protein sorting-associated protein 51 homolog;
DE   AltName: Full=Protein fat-free homolog;
GN   Name=vps51; Synonyms=ffr;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in retrograde transport from early and late
CC       endosomes to the late Golgi. The GARP complex is required for the
CC       maintenance of protein retrieval from endosomes to the TGN, acid
CC       hydrolase sorting, lysosome function, endosomal cholesterol traffic and
CC       autophagy. Acts as component of the EARP complex that is involved in
CC       endocytic recycling. {ECO:0000250|UniProtKB:Q9UID3}.
CC   -!- SUBUNIT: Component of the Golgi-associated retrograde protein (GARP)
CC       complex Component of the endosome-associated retrograde protein (EARP)
CC       complex. {ECO:0000250|UniProtKB:Q9UID3}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network
CC       {ECO:0000250|UniProtKB:Q9UID3}. Recycling endosome
CC       {ECO:0000250|UniProtKB:Q9UID3}. Note=Localizes to the trans-Golgi
CC       network as part of the GARP complex, while it localizes to recycling
CC       endosomes as part of the EARP complex. {ECO:0000250|UniProtKB:Q9UID3}.
CC   -!- SIMILARITY: Belongs to the VPS51 family. {ECO:0000305}.
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DR   EMBL; BC094495; AAH94495.1; -; mRNA.
DR   RefSeq; NP_001089434.1; NM_001095965.1.
DR   AlphaFoldDB; Q505L3; -.
DR   DNASU; 734484; -.
DR   GeneID; 734484; -.
DR   KEGG; xla:734484; -.
DR   CTD; 734484; -.
DR   Xenbase; XB-GENE-1005396; vps51.S.
DR   OrthoDB; 1305393at2759; -.
DR   Proteomes; UP000186698; Chromosome 4S.
DR   Bgee; 734484; Expressed in testis and 19 other tissues.
DR   GO; GO:1990745; C:EARP complex; ISS:UniProtKB.
DR   GO; GO:0000938; C:GARP complex; ISS:UniProtKB.
DR   GO; GO:0055037; C:recycling endosome; ISS:UniProtKB.
DR   GO; GO:0032456; P:endocytic recycling; ISS:UniProtKB.
DR   GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   InterPro; IPR016159; Cullin_repeat-like_dom_sf.
DR   InterPro; IPR039481; EXOC2/Sec5_N_dom.
DR   InterPro; IPR014812; Vps51.
DR   PANTHER; PTHR15954; PTHR15954; 1.
DR   Pfam; PF15469; Sec5; 1.
DR   SUPFAM; SSF74788; SSF74788; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Endosome; Golgi apparatus; Lipid transport; Protein transport;
KW   Reference proteome; Transport.
FT   CHAIN           1..757
FT                   /note="Vacuolar protein sorting-associated protein 51
FT                   homolog"
FT                   /id="PRO_0000361541"
FT   COILED          94..124
FT                   /evidence="ECO:0000255"
FT   COILED          371..392
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   757 AA;  84787 MW;  6EF9850345FBE5EC CRC64;
     MATVEEEESA KKKKSHGILK LYYGMTEEGK AAERHLEPTD VDGVHFNPEL YLTKLRKESS
     LSQLMDVEAD MVRQIRSLDS EMQTLVYENY NKFISATDTI RKMKNDFKKM EDEMDGLASN
     MAVITEFSAR ISSTLQVSHQ QITKLSGVHT LLRKLQFLFE LPARLKKCIE LGAYGQAVSY
     HSKARSVLHQ YQHMPSFHGI QTDCQAIMAG LADTLRQRFR DPASSPQELS ECVEMLLNLE
     EPAHLLCDEF LAHGRGRLAS HLSDLQESGD ILEFVDRGCG GFISDACLLA ASYQSLFSKE
     PGNSAQMAEA KLTVFLEELS TGYFELVEKR LHQEKSLGDN SLLVRALDRF HRRLQAPSKL
     VPGCGFNRRG TEIVVRAAQE RLAQYLQSLK EFFQGCLTDV RQALAAPRLP GKETSGLGDL
     LAGLSASVLN QIKTVLAAVH LFTAKDVAFS NKAYFKGEFC SQGVREGLIV AFITSVCQTA
     RQFCEIPGEK GTSTPPSLLL LLSRLCLDYE TSTISYILTL TDEQFLGQDR SPVTPVSSLC
     SLARSTAQTL LNQFVKYQGL VVSQMLRKSV ETRDWVTTIE PRNVRAVMKR VVEDITGVDV
     QVGLLYEEGA RKAHSSDSSK RTFSVYSSSR LQGRYAQSYT PSAPMDTNLL SNIQKLFSER
     IDIFSSVQFN KVSILTGIIK ISLKTFLECV RLRTFGRYGL QQIQVDCHYL QLYLWRFVSD
     ENLVHCLLDE VVGSAAHRCL DPAPMEQSVI EVICERG