ID   VPS51_XENTR             Reviewed;         760 AA.
AC   Q4V9Y0;
DT   20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2005, sequence version 1.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=Vacuolar protein sorting-associated protein 51 homolog;
DE   AltName: Full=Protein fat-free homolog;
GN   Name=vps51; Synonyms=ffr;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in retrograde transport from early and late
CC       endosomes to the late Golgi. The GARP complex is required for the
CC       maintenance of protein retrieval from endosomes to the TGN, acid
CC       hydrolase sorting, lysosome function, endosomal cholesterol traffic and
CC       autophagy. Acts as component of the EARP complex that is involved in
CC       endocytic recycling. {ECO:0000250|UniProtKB:Q9UID3}.
CC   -!- SUBUNIT: Component of the Golgi-associated retrograde protein (GARP)
CC       complex Component of the endosome-associated retrograde protein (EARP)
CC       complex. {ECO:0000250|UniProtKB:Q9UID3}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network
CC       {ECO:0000250|UniProtKB:Q9UID3}. Recycling endosome
CC       {ECO:0000250|UniProtKB:Q9UID3}. Note=Localizes to the trans-Golgi
CC       network as part of the GARP complex, while it localizes to recycling
CC       endosomes as part of the EARP complex. {ECO:0000250|UniProtKB:Q9UID3}.
CC   -!- SIMILARITY: Belongs to the VPS51 family. {ECO:0000305}.
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DR   EMBL; BC096636; AAH96636.1; -; mRNA.
DR   RefSeq; NP_001027521.1; NM_001032350.1.
DR   AlphaFoldDB; Q4V9Y0; -.
DR   SMR; Q4V9Y0; -.
DR   PaxDb; Q4V9Y0; -.
DR   DNASU; 613113; -.
DR   GeneID; 613113; -.
DR   KEGG; xtr:613113; -.
DR   CTD; 738; -.
DR   Xenbase; XB-GENE-1005391; vps51.
DR   eggNOG; KOG2346; Eukaryota.
DR   InParanoid; Q4V9Y0; -.
DR   OrthoDB; 1305393at2759; -.
DR   Reactome; R-XTR-6811440; Retrograde transport at the Trans-Golgi-Network.
DR   Proteomes; UP000008143; Chromosome 4.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0005829; C:cytosol; IEA:GOC.
DR   GO; GO:1990745; C:EARP complex; ISS:UniProtKB.
DR   GO; GO:0000938; C:GARP complex; ISS:UniProtKB.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   GO; GO:0055037; C:recycling endosome; ISS:UniProtKB.
DR   GO; GO:0032456; P:endocytic recycling; ISS:UniProtKB.
DR   GO; GO:0007030; P:Golgi organization; IBA:GO_Central.
DR   GO; GO:0048193; P:Golgi vesicle transport; IBA:GO_Central.
DR   GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR   GO; GO:0007041; P:lysosomal transport; IBA:GO_Central.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   GO; GO:0042147; P:retrograde transport, endosome to Golgi; IBA:GO_Central.
DR   InterPro; IPR016159; Cullin_repeat-like_dom_sf.
DR   InterPro; IPR039481; EXOC2/Sec5_N_dom.
DR   InterPro; IPR014812; Vps51.
DR   PANTHER; PTHR15954; PTHR15954; 1.
DR   Pfam; PF15469; Sec5; 1.
DR   SUPFAM; SSF74788; SSF74788; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Endosome; Golgi apparatus; Lipid transport; Protein transport;
KW   Reference proteome; Transport.
FT   CHAIN           1..760
FT                   /note="Vacuolar protein sorting-associated protein 51
FT                   homolog"
FT                   /id="PRO_0000361542"
FT   COILED          97..127
FT                   /evidence="ECO:0000255"
FT   COILED          374..395
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   760 AA;  85228 MW;  80000FA36D6F8F55 CRC64;
     MATVSGTEEE ENAKKRKAHG MLKLYYGMTE EGKACERHLE PTDVDGVHFN PELYLTKLRK
     ESSLSQLMDV EADMVRQIRS LDSEMQTLVY ENYNKFISAT DTIRKMKNDF KKMEDEMDGL
     ATNMAVITEF SARISSTLQE RHQQITKLSG VHTLLRKLQF LFELPARLKK CIELGAYAQA
     VSYHSKARSV LHQYQHMPSF HGIQTDCQAI MAGLADTLRQ RFRDPASSPQ DLSECVEMLL
     NLEEPAHLLC DEFLAHGRGR LASHLSDLQE SGDILEFVDR GCGGFISDAC LLAASYQSLF
     SKEAGSTAQM AEAKLTSFLE ELSTGYFELV EKRLRQEKSL GDNSLLVRAL DRFHRRLQAP
     SKLVPGCGFN RRGTEIVVRA AQERLAQYLQ ALKDFFQGCL TDVRQALAAP RLPGKEMPAL
     GDLLAGLSAS VLNQIKTVLA AVHLFTAKDV AFSDKPYFKG EFCSQGVREG LIVAFIKSVC
     QTARQFCEIP GEKGTSTPPA LLLLLSRLCL DYETSTISYI LTLTDEQFLG QDHSPVTPVS
     SLCSLARSTA QTLLNQYVKS QGLVVSQMLR KSVETRDWVT TIEPRNVRAV MKRVVEDITG
     VDVQVGLLYE EGVRKAHSSD SSKRTFSVYS SSRLQGRYAQ SYTPSAPMDT NLLSNIQKLF
     SERIDIFSTV QFNKVSILTG IIKISLKTFL ECVRLRTFGR YGLQQIQVDC HYLQLYLWRF
     VSDENLVHCL LDEVVGSAAH RCLDPAPMEQ SVIEVICERG