VPS52_SCHPO
ID VPS52_SCHPO Reviewed; 508 AA.
AC Q9UST3;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 25-MAY-2022, entry version 95.
DE RecName: Full=Vacuolar protein sorting-associated protein 52;
GN Name=vps52; ORFNames=SPBC336.11;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
CC -!- FUNCTION: Involved in retrograde transport from early and late
CC endosomes to late Golgi by linking the vesicle through the t-SNARE TGL1
CC to the Golgi, leading to the membrane fusion between late Golgi and
CC endosomal vesicles. {ECO:0000250}.
CC -!- SUBUNIT: Component of the Golgi-associated retrograde protein (GARP)
CC complex. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane
CC {ECO:0000269|PubMed:16823372}; Peripheral membrane protein
CC {ECO:0000269|PubMed:16823372}.
CC -!- SIMILARITY: Belongs to the VPS52 family. {ECO:0000305}.
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DR EMBL; CU329671; CAB58163.1; -; Genomic_DNA.
DR PIR; T40249; T40249.
DR RefSeq; NP_596131.1; NM_001022049.2.
DR AlphaFoldDB; Q9UST3; -.
DR SMR; Q9UST3; -.
DR STRING; 4896.SPBC336.11.1; -.
DR MaxQB; Q9UST3; -.
DR PaxDb; Q9UST3; -.
DR EnsemblFungi; SPBC336.11.1; SPBC336.11.1:pep; SPBC336.11.
DR GeneID; 2540233; -.
DR KEGG; spo:SPBC336.11; -.
DR PomBase; SPBC336.11; vps52.
DR VEuPathDB; FungiDB:SPBC336.11; -.
DR eggNOG; KOG1961; Eukaryota.
DR HOGENOM; CLU_010797_1_0_1; -.
DR InParanoid; Q9UST3; -.
DR OMA; IHVVMVE; -.
DR PhylomeDB; Q9UST3; -.
DR PRO; PR:Q9UST3; -.
DR Proteomes; UP000002485; Chromosome II.
DR GO; GO:0005829; C:cytosol; IEA:GOC.
DR GO; GO:0000938; C:GARP complex; ISO:PomBase.
DR GO; GO:0005794; C:Golgi apparatus; HDA:PomBase.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0019905; F:syntaxin binding; IBA:GO_Central.
DR GO; GO:0030029; P:actin filament-based process; ISO:PomBase.
DR GO; GO:0032456; P:endocytic recycling; IBA:GO_Central.
DR GO; GO:0006896; P:Golgi to vacuole transport; ISO:PomBase.
DR GO; GO:0006886; P:intracellular protein transport; IC:PomBase.
DR GO; GO:0042147; P:retrograde transport, endosome to Golgi; ISO:PomBase.
DR InterPro; IPR007258; Vps52.
DR PANTHER; PTHR14190; PTHR14190; 1.
DR Pfam; PF04129; Vps52; 1.
PE 3: Inferred from homology;
KW Golgi apparatus; Membrane; Protein transport; Reference proteome;
KW Transport.
FT CHAIN 1..508
FT /note="Vacuolar protein sorting-associated protein 52"
FT /id="PRO_0000317078"
SQ SEQUENCE 508 AA; 58385 MW; D67B1DF94CD12ABB CRC64;
MQRASTQDVY DGSGDDLNKL DSLKSVLNDV LSSLERFQVD LDVATSDIYK VSERSNKIQV
NLNNLKAVES ALGAEIDGAI LPPDLIKTIS TGDMDHPSWN SALEKLTSFL EGGEDDSSLG
NMFNSLQINK DQKKLVDKLR DKAIERIRNY IVVTIKMFRQ AFVDVFPIRK HRLIANKNYY
LFLFKFNRKL ALELQRAYIN TMNWFYLYHF EQYSRFLDKV HVLKGETIRV EEDRKGLFNL
SKGAQQSYGN QMLSVNLRPQ DFDMNSVLTA STMHHIESSP QYIERVYCSW ELVLTEHVSS
EYAFLLEYFN LSKDQQATVF AAIFEKTLHF SRKYITGLIS SSIDCIGILK SIRFTQKLAL
QAQTNIVPVI EPHYNSMILF LWPRFQAVMD MHCESLRKTN LSVKPEEITS RPHPLSQRVA
ELLYSLSMLS VNVVEAEPVA RSASRLAQDY VSMLQNLCKT VNDKRRQSRF LSNNYTLIST
VLSGVSGNLA IEQKTYFEKL NENLTNFQ
