ID   VPS53_CHICK             Reviewed;         831 AA.
AC   Q5ZLD7;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 83.
DE   RecName: Full=Vacuolar protein sorting-associated protein 53 homolog;
GN   Name=VPS53; ORFNames=RCJMB04_6k3;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=CB; TISSUE=Bursa of Fabricius;
RX   PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA   Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA   Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA   Hayashizaki Y., Buerstedde J.-M.;
RT   "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT   function analysis.";
RL   Genome Biol. 6:R6.1-R6.9(2005).
CC   -!- FUNCTION: Acts as component of the GARP complex that is involved in
CC       retrograde transport from early and late endosomes to the trans-Golgi
CC       network (TGN). Acts as component of the EARP complex that is involved
CC       in endocytic recycling. {ECO:0000250|UniProtKB:Q5VIR6}.
CC   -!- SUBUNIT: Component of the Golgi-associated retrograde protein (GARP)
CC       complex. Component of the endosome-associated retrograde protein (EARP)
CC       complex. {ECO:0000250|UniProtKB:Q5VIR6}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane
CC       {ECO:0000250|UniProtKB:Q5VIR6}; Peripheral membrane protein
CC       {ECO:0000250|UniProtKB:Q5VIR6}. Endosome membrane
CC       {ECO:0000250|UniProtKB:Q5VIR6}; Peripheral membrane protein
CC       {ECO:0000250|UniProtKB:Q5VIR6}. Recycling endosome
CC       {ECO:0000250|UniProtKB:Q5VIR6}. Note=Localizes to the trans-Golgi
CC       network as part of the GARP complex, while it localizes to recycling
CC       endosomes as part of the EARP complex. {ECO:0000250|UniProtKB:Q5VIR6}.
CC   -!- SIMILARITY: Belongs to the VPS53 family. {ECO:0000305}.
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DR   EMBL; AJ719797; CAG31456.1; -; mRNA.
DR   RefSeq; NP_001012824.1; NM_001012806.1.
DR   AlphaFoldDB; Q5ZLD7; -.
DR   SMR; Q5ZLD7; -.
DR   STRING; 9031.ENSGALP00000007788; -.
DR   PaxDb; Q5ZLD7; -.
DR   Ensembl; ENSGALT00000069223; ENSGALP00000045679; ENSGALG00000042071.
DR   GeneID; 417622; -.
DR   KEGG; gga:417622; -.
DR   CTD; 55275; -.
DR   VEuPathDB; HostDB:geneid_417622; -.
DR   eggNOG; KOG2180; Eukaryota.
DR   GeneTree; ENSGT00390000015165; -.
DR   InParanoid; Q5ZLD7; -.
DR   OMA; YKFAEAK; -.
DR   OrthoDB; 1379600at2759; -.
DR   PhylomeDB; Q5ZLD7; -.
DR   PRO; PR:Q5ZLD7; -.
DR   Proteomes; UP000000539; Chromosome 19.
DR   Bgee; ENSGALG00000042071; Expressed in ovary and 13 other tissues.
DR   GO; GO:0005829; C:cytosol; IEA:GOC.
DR   GO; GO:1990745; C:EARP complex; ISS:UniProtKB.
DR   GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0000938; C:GARP complex; IBA:GO_Central.
DR   GO; GO:0055037; C:recycling endosome; ISS:UniProtKB.
DR   GO; GO:0032456; P:endocytic recycling; ISS:UniProtKB.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   GO; GO:0042147; P:retrograde transport, endosome to Golgi; ISS:UniProtKB.
DR   Gene3D; 1.10.357.110; -; 1.
DR   InterPro; IPR039766; Vps53.
DR   InterPro; IPR038260; Vps53_C_sf.
DR   InterPro; IPR007234; Vps53_N.
DR   PANTHER; PTHR12820; PTHR12820; 1.
DR   Pfam; PF04100; Vps53_N; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Endosome; Golgi apparatus; Membrane; Protein transport;
KW   Reference proteome; Transport.
FT   CHAIN           1..831
FT                   /note="Vacuolar protein sorting-associated protein 53
FT                   homolog"
FT                   /id="PRO_0000215192"
FT   REGION          370..391
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          794..819
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          54..141
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        798..816
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   831 AA;  93705 MW;  0D8DD5325D102911 CRC64;
     MEEDELELAA GLEAALELAP AVQAAIEQVF PSQDPLDRAD FNAVEYINTL FPTEQSLANI
     DEVVNKIRLK IRKLDDNIRT VVRGQTNVGQ DGRQALEEAQ KAIQQLFGKI KDIKDKAEKS
     EQMVKEITRD IKQLDHAKRH LTTSITTLNH LHMLAGGVDS LEAMTRRRQY GEVANLLQGV
     VNVLEHFNKY MGIPQIRQLS ERVKAAQNEL GQQILADFEE AFPSQGTKRP GGPSNVLRDA
     CLVANVLDPR IKQEIIKKFI KQHLSEYLVL FQENQDVAWL DKIDRRYAWI KRQLVDYEEK
     YGRMFPQEWC MTERIAVEFC HVTRTELAKI MRTRAKEIEV KLLLFAIQRT TNFEGLLAKR
     FSGCTLADGT VKKPEAPPPS TNPFLEDETG TETDEIVIEK SDADKPKKPK VPDNPFHGIV
     SKCFEPHLYV YIESQDKNLS ELIDRFVADF KAQGPPKPNV DEGGAVLPSC ADLFVYYKKC
     MVQCSQLSTG EPMIALTTIF QKYLREYAWK ILSGNLPKTT SSSGGLTITS LLKEKEGSEV
     AKFTLEELCL ICSILSTAEY CLATTQQLEE KLKEKVDASL VERINLTGET DTFSIVISNS
     IQLLVQDLDA ACDPALTAMS KMQWQNVEHV GDQSPYVTSV ILHIKQNVPI IRDNLASTRK
     YFTQFCIKFA NSFIPKFINH LFKCKPISMV GAEQLLLDTH SLKMVLLDLP SIGSQVVRKA
     PASYTRIVVK GMTRAEMILK VVMAPHEPPV VFVDNYIKLL ADCSTDTFQK ILDMKGLKRS
     EQSSMLELFR QRLPAPPSGV ENSGSLSLSA PTPEQESSRI RKLEKLIKKR L