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VPS54_CAEBR
ID   VPS54_CAEBR             Reviewed;        1055 AA.
AC   Q61JT8; A8X8K6;
DT   10-MAY-2005, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 78.
DE   RecName: Full=Vacuolar protein sorting-associated protein 54;
GN   Name=vps-54; ORFNames=CBG09643;
OS   Caenorhabditis briggsae.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6238;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AF16;
RX   PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA   Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA   Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA   Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA   Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA   Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA   Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA   Durbin R.M., Waterston R.H.;
RT   "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT   genomics.";
RL   PLoS Biol. 1:166-192(2003).
CC   -!- FUNCTION: Acts as component of the GARP complex that is involved in
CC       retrograde transport from early and late endosomes to the trans-Golgi
CC       network (TGN). The GARP complex facilitates tethering as well as SNARE
CC       complex assembly at the Golgi (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the Golgi-associated retrograde protein (GARP)
CC       complex, also called VFT (VPS fifty-three) complex, composed of VPS51,
CC       VPS52, VPS53 and VPS54. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the VPS54 family. {ECO:0000305}.
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DR   EMBL; HE600998; CAP28967.1; -; Genomic_DNA.
DR   RefSeq; XP_002637141.1; XM_002637095.1.
DR   AlphaFoldDB; Q61JT8; -.
DR   SMR; Q61JT8; -.
DR   STRING; 6238.CBG09643; -.
DR   GeneID; 8579137; -.
DR   KEGG; cbr:CBG_09643; -.
DR   CTD; 8579137; -.
DR   WormBase; CBG09643; CBP43059; WBGene00031201; Cbr-vps-54.
DR   eggNOG; KOG2115; Eukaryota.
DR   HOGENOM; CLU_005185_1_0_1; -.
DR   InParanoid; Q61JT8; -.
DR   OMA; FSFVQSY; -.
DR   OrthoDB; 449680at2759; -.
DR   Proteomes; UP000008549; Chromosome V.
DR   GO; GO:0005829; C:cytosol; IEA:GOC.
DR   GO; GO:0000938; C:GARP complex; IBA:GO_Central.
DR   GO; GO:0019905; F:syntaxin binding; IBA:GO_Central.
DR   GO; GO:0006896; P:Golgi to vacuole transport; IBA:GO_Central.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   GO; GO:0042147; P:retrograde transport, endosome to Golgi; IBA:GO_Central.
DR   InterPro; IPR039745; Vps54.
DR   InterPro; IPR012501; Vps54_C.
DR   InterPro; IPR019515; VPS54_N.
DR   PANTHER; PTHR12965; PTHR12965; 1.
DR   Pfam; PF07928; Vps54; 1.
DR   Pfam; PF10475; Vps54_N; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Golgi apparatus; Protein transport; Reference proteome;
KW   Transport.
FT   CHAIN           1..1055
FT                   /note="Vacuolar protein sorting-associated protein 54"
FT                   /id="PRO_0000148734"
FT   REGION          774..794
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          363..383
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   1055 AA;  118801 MW;  98F507DBC8FE5622 CRC64;
     MKAMEERTVG LISASSSRAS LKTQLENGYP RICDYCEPTI EFLSSSELAR HIRQDHTTQE
     GGSFLCRYGE HGVCQKLPLE GVCDVDFEAH IRRCHTSQSV PYSRSTSCFT EDNEEAASLR
     SIRLTSDRDT PTIEKKKFTL HSFTQNLSAV LADPSRSRND LSTFFTRHWG DTFVPTQPVP
     TSKRLAKMAD ASFDSYCQAA GESYKRYQAV KRALRLSHTE GTESGNERQD AEDLPTVFID
     PRFTLGDSST FSAVFTVPAN ENLDALKQTL SGKNVIPATP LEVAINKKPG EFRDYEALQN
     RLEMMHDVVD GRLAGKLVAK TDDFWQVVRS YSGLQEQLAN ALQCVMVVRK NLKHVDELVC
     DQTKKIIEVH QKYEQKKHLL AKLNDIACLR EAQSTVQMML SQGDYPKAIE CIETSLDVLS
     KELNGVTCFR HLSSQLRELY SVIGRMMNED FTSLIQKEFG VKPEAGTLIQ AEGELSAVLL
     GLMRMRKYTF ISVLREEIIE GVKSVMRHVI KSQILNSGVD LSDFDPSLTQ LGEPVRRMKH
     ADFLKTVRAV MDEEYFFCKR LEALQDILLE TAQRAHPSNR HGSEDIIIER LEEAKLNESD
     SDDETGSFSK STSSGGFVSG SAVNSNATAT TLLSIEVRSE AFLKRVLPLI AEFGHQCAQQ
     RISRLLIARA KNASVTEATT PTQLSECIAI VKEYQSQCEE EGWYSTQNQK AGGLGRAINK
     LSMDYIEKFH AARKMRIGNM LDTELWKATD VSIIDQNMVD QAIETGMLRS SKRIDDGPTK
     KPFKRTGSSA TIDSGTSVSN QTGIIVDEES FVVVGSSITM IQILADYCEA ISKMPTFAQD
     WNSRVIELLK TFNSRCCQLI LGAGALQLVG LKTISVRNLG TIFVNLTLAG RSLELVCRFI
     PMVHDEMDRV LPDDRKSLLR YFKGVESEYR DHVNEIAIKL ISVIAHYTTN CLGMWDVKGN
     IPSPEFQQIC RHMLKFHNGL TGIMPRDQIE SLFRQVHENF KANLREHVTG MGIRPHDTLK
     YGYVTQDYMY YQQNVKNMES CRNLELESLN DIMFD
 
 
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