VPS54_CAEBR
ID VPS54_CAEBR Reviewed; 1055 AA.
AC Q61JT8; A8X8K6;
DT 10-MAY-2005, integrated into UniProtKB/Swiss-Prot.
DT 23-NOV-2004, sequence version 1.
DT 03-AUG-2022, entry version 78.
DE RecName: Full=Vacuolar protein sorting-associated protein 54;
GN Name=vps-54; ORFNames=CBG09643;
OS Caenorhabditis briggsae.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6238;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AF16;
RX PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA Durbin R.M., Waterston R.H.;
RT "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT genomics.";
RL PLoS Biol. 1:166-192(2003).
CC -!- FUNCTION: Acts as component of the GARP complex that is involved in
CC retrograde transport from early and late endosomes to the trans-Golgi
CC network (TGN). The GARP complex facilitates tethering as well as SNARE
CC complex assembly at the Golgi (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Component of the Golgi-associated retrograde protein (GARP)
CC complex, also called VFT (VPS fifty-three) complex, composed of VPS51,
CC VPS52, VPS53 and VPS54. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the VPS54 family. {ECO:0000305}.
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DR EMBL; HE600998; CAP28967.1; -; Genomic_DNA.
DR RefSeq; XP_002637141.1; XM_002637095.1.
DR AlphaFoldDB; Q61JT8; -.
DR SMR; Q61JT8; -.
DR STRING; 6238.CBG09643; -.
DR GeneID; 8579137; -.
DR KEGG; cbr:CBG_09643; -.
DR CTD; 8579137; -.
DR WormBase; CBG09643; CBP43059; WBGene00031201; Cbr-vps-54.
DR eggNOG; KOG2115; Eukaryota.
DR HOGENOM; CLU_005185_1_0_1; -.
DR InParanoid; Q61JT8; -.
DR OMA; FSFVQSY; -.
DR OrthoDB; 449680at2759; -.
DR Proteomes; UP000008549; Chromosome V.
DR GO; GO:0005829; C:cytosol; IEA:GOC.
DR GO; GO:0000938; C:GARP complex; IBA:GO_Central.
DR GO; GO:0019905; F:syntaxin binding; IBA:GO_Central.
DR GO; GO:0006896; P:Golgi to vacuole transport; IBA:GO_Central.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0042147; P:retrograde transport, endosome to Golgi; IBA:GO_Central.
DR InterPro; IPR039745; Vps54.
DR InterPro; IPR012501; Vps54_C.
DR InterPro; IPR019515; VPS54_N.
DR PANTHER; PTHR12965; PTHR12965; 1.
DR Pfam; PF07928; Vps54; 1.
DR Pfam; PF10475; Vps54_N; 1.
PE 3: Inferred from homology;
KW Coiled coil; Golgi apparatus; Protein transport; Reference proteome;
KW Transport.
FT CHAIN 1..1055
FT /note="Vacuolar protein sorting-associated protein 54"
FT /id="PRO_0000148734"
FT REGION 774..794
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 363..383
FT /evidence="ECO:0000255"
SQ SEQUENCE 1055 AA; 118801 MW; 98F507DBC8FE5622 CRC64;
MKAMEERTVG LISASSSRAS LKTQLENGYP RICDYCEPTI EFLSSSELAR HIRQDHTTQE
GGSFLCRYGE HGVCQKLPLE GVCDVDFEAH IRRCHTSQSV PYSRSTSCFT EDNEEAASLR
SIRLTSDRDT PTIEKKKFTL HSFTQNLSAV LADPSRSRND LSTFFTRHWG DTFVPTQPVP
TSKRLAKMAD ASFDSYCQAA GESYKRYQAV KRALRLSHTE GTESGNERQD AEDLPTVFID
PRFTLGDSST FSAVFTVPAN ENLDALKQTL SGKNVIPATP LEVAINKKPG EFRDYEALQN
RLEMMHDVVD GRLAGKLVAK TDDFWQVVRS YSGLQEQLAN ALQCVMVVRK NLKHVDELVC
DQTKKIIEVH QKYEQKKHLL AKLNDIACLR EAQSTVQMML SQGDYPKAIE CIETSLDVLS
KELNGVTCFR HLSSQLRELY SVIGRMMNED FTSLIQKEFG VKPEAGTLIQ AEGELSAVLL
GLMRMRKYTF ISVLREEIIE GVKSVMRHVI KSQILNSGVD LSDFDPSLTQ LGEPVRRMKH
ADFLKTVRAV MDEEYFFCKR LEALQDILLE TAQRAHPSNR HGSEDIIIER LEEAKLNESD
SDDETGSFSK STSSGGFVSG SAVNSNATAT TLLSIEVRSE AFLKRVLPLI AEFGHQCAQQ
RISRLLIARA KNASVTEATT PTQLSECIAI VKEYQSQCEE EGWYSTQNQK AGGLGRAINK
LSMDYIEKFH AARKMRIGNM LDTELWKATD VSIIDQNMVD QAIETGMLRS SKRIDDGPTK
KPFKRTGSSA TIDSGTSVSN QTGIIVDEES FVVVGSSITM IQILADYCEA ISKMPTFAQD
WNSRVIELLK TFNSRCCQLI LGAGALQLVG LKTISVRNLG TIFVNLTLAG RSLELVCRFI
PMVHDEMDRV LPDDRKSLLR YFKGVESEYR DHVNEIAIKL ISVIAHYTTN CLGMWDVKGN
IPSPEFQQIC RHMLKFHNGL TGIMPRDQIE SLFRQVHENF KANLREHVTG MGIRPHDTLK
YGYVTQDYMY YQQNVKNMES CRNLELESLN DIMFD