VPS55_CAEEL
ID VPS55_CAEEL Reviewed; 132 AA.
AC Q18319; Q7JPI9; Q7JPJ0; Q95QS8;
DT 15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT 25-OCT-2004, sequence version 3.
DT 03-AUG-2022, entry version 118.
DE RecName: Full=Vacuolar protein sorting-associated protein 55 homolog;
GN ORFNames=C30B5.2;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND ALTERNATIVE SPLICING.
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- FUNCTION: Involved in endosomal protein transport. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Endosome membrane {ECO:0000250}; Multi-pass
CC membrane protein {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=a;
CC IsoId=Q18319-1; Sequence=Displayed;
CC Name=b;
CC IsoId=Q18319-2; Sequence=VSP_003745;
CC -!- SIMILARITY: Belongs to the OB-RGRP/VPS55 family. {ECO:0000305}.
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DR EMBL; FO080719; CCD66134.1; -; Genomic_DNA.
DR EMBL; FO080719; CCD66135.1; -; Genomic_DNA.
DR RefSeq; NP_495238.2; NM_062837.7. [Q18319-1]
DR RefSeq; NP_495239.2; NM_062838.4.
DR AlphaFoldDB; Q18319; -.
DR STRING; 6239.C30B5.2a; -.
DR PaxDb; Q18319; -.
DR EnsemblMetazoa; C30B5.2a.1; C30B5.2a.1; WBGene00016244. [Q18319-1]
DR EnsemblMetazoa; C30B5.2b.1; C30B5.2b.1; WBGene00016244. [Q18319-2]
DR GeneID; 174028; -.
DR KEGG; cel:CELE_C30B5.2; -.
DR UCSC; C30B5.2a; c. elegans. [Q18319-1]
DR CTD; 174028; -.
DR WormBase; C30B5.2a; CE31889; WBGene00016244; -. [Q18319-1]
DR WormBase; C30B5.2b; CE31890; WBGene00016244; -. [Q18319-2]
DR eggNOG; KOG2174; Eukaryota.
DR GeneTree; ENSGT00390000006503; -.
DR HOGENOM; CLU_134810_2_2_1; -.
DR InParanoid; Q18319; -.
DR OMA; HSAVITW; -.
DR OrthoDB; 1642378at2759; -.
DR PhylomeDB; Q18319; -.
DR PRO; PR:Q18319; -.
DR Proteomes; UP000001940; Chromosome II.
DR Bgee; WBGene00016244; Expressed in germ line (C elegans) and 4 other tissues.
DR GO; GO:0005768; C:endosome; IBA:GO_Central.
DR GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0032511; P:late endosome to vacuole transport via multivesicular body sorting pathway; IBA:GO_Central.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR InterPro; IPR007262; Vps55/LEPROT.
DR PANTHER; PTHR12050; PTHR12050; 1.
DR Pfam; PF04133; Vps55; 1.
PE 3: Inferred from homology;
KW Alternative splicing; Endosome; Membrane; Protein transport;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..132
FT /note="Vacuolar protein sorting-associated protein 55
FT homolog"
FT /id="PRO_0000215200"
FT TRANSMEM 7..27
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 32..52
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 68..88
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 98..118
FT /note="Helical"
FT /evidence="ECO:0000255"
FT VAR_SEQ 30..31
FT /note="Missing (in isoform b)"
FT /evidence="ECO:0000305"
FT /id="VSP_003745"
SQ SEQUENCE 132 AA; 14117 MW; 469022EEB406C0C0 CRC64;
MGGVRAVAAL AFAGVVGLTF LVLGCALPRY GTWTPMFVIT FYVLSPVPLL IARRFQEDMT
GTNACIELAL FITTGIVISA FALPIVLAHA GTIANSACFL VNTGSVIMFG TIIAYFYLHR
DDDSGSWSQS LF
