VPS55_DICDI
ID VPS55_DICDI Reviewed; 125 AA.
AC Q54VP1;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 25-MAY-2022, entry version 72.
DE RecName: Full=Vacuolar protein sorting-associated protein 55 homolog;
GN Name=vps55; ORFNames=DDB_G0280219;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: Involved in endosomal protein transport. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Endosome membrane {ECO:0000250}; Multi-pass
CC membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the OB-RGRP/VPS55 family. {ECO:0000305}.
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DR EMBL; AAFI02000035; EAL67336.1; -; Genomic_DNA.
DR RefSeq; XP_641314.1; XM_636222.1.
DR AlphaFoldDB; Q54VP1; -.
DR STRING; 44689.DDB0233395; -.
DR PaxDb; Q54VP1; -.
DR EnsemblProtists; EAL67336; EAL67336; DDB_G0280219.
DR GeneID; 8622446; -.
DR KEGG; ddi:DDB_G0280219; -.
DR dictyBase; DDB_G0280219; vps55.
DR eggNOG; KOG2174; Eukaryota.
DR HOGENOM; CLU_134810_0_0_1; -.
DR InParanoid; Q54VP1; -.
DR OMA; HSAVITW; -.
DR PhylomeDB; Q54VP1; -.
DR PRO; PR:Q54VP1; -.
DR Proteomes; UP000002195; Chromosome 3.
DR GO; GO:0005768; C:endosome; IBA:GO_Central.
DR GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005770; C:late endosome; ISS:dictyBase.
DR GO; GO:0045324; P:late endosome to vacuole transport; ISS:dictyBase.
DR GO; GO:0032511; P:late endosome to vacuole transport via multivesicular body sorting pathway; IBA:GO_Central.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR InterPro; IPR007262; Vps55/LEPROT.
DR PANTHER; PTHR12050; PTHR12050; 1.
DR Pfam; PF04133; Vps55; 1.
PE 3: Inferred from homology;
KW Endosome; Membrane; Protein transport; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..125
FT /note="Vacuolar protein sorting-associated protein 55
FT homolog"
FT /id="PRO_0000327390"
FT TOPO_DOM 1..4
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 5..25
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 26..27
FT /note="Lumenal"
FT /evidence="ECO:0000250"
FT TRANSMEM 28..48
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 49..63
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 64..84
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 85..94
FT /note="Lumenal"
FT /evidence="ECO:0000250"
FT TRANSMEM 95..115
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 116..125
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
SQ SEQUENCE 125 AA; 13708 MW; 5AC06D50944835CD CRC64;
MGHDIKGFSC AFAVGLLFNI LACIVSHSGY PIIVVASYFL APFPNILCRN RDSFSSEKGT
FEDIGLFLTG LFITSGFAIP MILAHSDIIS GKALAFSMAG GVTVYATIIT FLWFFNRHND
EDNNW
