ID   VPS61_YEAST             Reviewed;         190 AA.
AC   Q03913;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 83.
DE   RecName: Full=Putative uncharacterized protein VPS61;
GN   Name=VPS61; OrderedLocusNames=YDR136C;
OS   Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=559292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=9169867;
RA   Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G.,
RA   Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C.,
RA   Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F.,
RA   Delaveau T., del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M.,
RA   Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T.,
RA   Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C.,
RA   Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S.,
RA   Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N., Paulin L.,
RA   Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M., Prydz H.,
RA   Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L., Rieger M.,
RA   Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M., Scharfe M.,
RA   Schmidt E.R., Schneider C., Scholler P., Schwarz S., Soler-Mira A.,
RA   Urrestarazu L.A., Verhasselt P., Vissers S., Voet M., Volckaert G.,
RA   Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S., Harris D.E.,
RA   Bowman S., Brown D., Churcher C.M., Connor R., Dedman K., Gentles S.,
RA   Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D., Niblett D.,
RA   Odell C., Oliver K., Rajandream M.A., Richards C., Shore L., Walsh S.V.,
RA   Barrell B.G., Dietrich F.S., Mulligan J.T., Allen E., Araujo R., Aviles E.,
RA   Berno A., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M.,
RA   Hunicke-Smith S., Hyman R.W., Komp C., Lashkari D., Lew H., Lin D.,
RA   Mosedale D., Nakahara K., Namath A., Oefner P., Oh C., Petel F.X.,
RA   Roberts D., Schramm S., Schroeder M., Shogren T., Shroff N., Winant A.,
RA   Yelton M.A., Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R.,
RA   Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S., Greco T.,
RA   Hallsworth K., Hawkins J., Hillier L.W., Jier M., Johnson D., Johnston L.,
RA   Kirsten J., Kucaba T., Langston Y., Latreille P., Le T., Mardis E.,
RA   Menezes S., Miller N., Nhan M., Pauley A., Peluso D., Rifkin L., Riles L.,
RA   Taich A., Trevaskis E., Vignati D., Wilcox L., Wohldman P., Vaudin M.,
RA   Wilson R., Waterston R., Albermann K., Hani J., Heumann K., Kleine K.,
RA   Mewes H.-W., Zollner A., Zaccaria P.;
RT   "The nucleotide sequence of Saccharomyces cerevisiae chromosome IV.";
RL   Nature 387:75-78(1997).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=24374639; DOI=10.1534/g3.113.008995;
RA   Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA   Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA   Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT   "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL   G3 (Bethesda) 4:389-398(2014).
RN   [3]
RP   DISRUPTION PHENOTYPE.
RX   PubMed=12134085; DOI=10.1091/mbc.02-01-0005;
RA   Bonangelino C.J., Chavez E.M., Bonifacino J.S.;
RT   "Genomic screen for vacuolar protein sorting genes in Saccharomyces
RT   cerevisiae.";
RL   Mol. Biol. Cell 13:2486-2501(2002).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
CC   -!- DISRUPTION PHENOTYPE: Deletion causes a vacuolar protein sorting
CC       defect. {ECO:0000269|PubMed:12134085}.
CC   -!- MISCELLANEOUS: Partially overlaps RGP1. Disruption phenotypes caused by
CC       deletion of this gene may also be a result of a defect in its
CC       overlapping gene. {ECO:0000305}.
CC   -!- CAUTION: Product of a dubious gene prediction unlikely to encode a
CC       functional protein. Because of that it is not part of the S.cerevisiae
CC       S288c complete/reference proteome set. {ECO:0000305|PubMed:24374639}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; Z48179; CAA88218.1; -; Genomic_DNA.
DR   PIR; S51864; S51864.
DR   AlphaFoldDB; Q03913; -.
DR   DIP; DIP-4335N; -.
DR   IntAct; Q03913; 1.
DR   STRING; 4932.YDR136C; -.
DR   PaxDb; Q03913; -.
DR   PRIDE; Q03913; -.
DR   EnsemblFungi; YDR136C_mRNA; YDR136C; YDR136C.
DR   SGD; S000002543; VPS61.
DR   HOGENOM; CLU_1305734_0_0_1; -.
DR   OMA; CFFMIIQ; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0006623; P:protein targeting to vacuole; HMP:SGD.
PE   5: Uncertain;
KW   Membrane; Transmembrane; Transmembrane helix.
FT   CHAIN           1..190
FT                   /note="Putative uncharacterized protein VPS61"
FT                   /id="PRO_0000299779"
FT   TRANSMEM        152..174
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   190 AA;  22811 MW;  8EF77F89405C9A12 CRC64;
     MYRFCAHAYL LLKYEKYHNQ NQQLKKLWAS FRCLFRLAAF ALPRRYQSFF EAELILKNST
     LETRLTLYRR LRSRLRLKNK NYTRSSSIMF NIQTTFPPHG EMKTFIVLRE VDLLLLSLEF
     MNVSLARADL LVRNLHYFAI HSTLVMLHQY EYIYLMLTSG FCRYLGVCFF MIIQKYVTPG
     VMLGRWKVTA