VPS62_YEAST
ID VPS62_YEAST Reviewed; 467 AA.
AC P53285; D6VUS1;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 1.
DT 03-AUG-2022, entry version 136.
DE RecName: Full=Vacuolar protein sorting-associated protein 62;
GN Name=VPS62; OrderedLocusNames=YGR141W;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169869;
RA Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J.,
RA Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M.,
RA Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L.,
RA Coblenz A., Coglievina M., Coissac E., Defoor E., Del Bino S., Delius H.,
RA Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P.,
RA Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M.,
RA Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A.,
RA Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K.,
RA Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P.,
RA Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E.,
RA Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K.,
RA Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A.,
RA Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S.,
RA Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M.,
RA Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C.,
RA Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M.,
RA Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M.,
RA Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y.,
RA Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L.,
RA Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D.,
RA Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F.,
RA Zaccaria P., Zimmermann M., Zollner A., Kleine K.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII.";
RL Nature 387:81-84(1997).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [3]
RP FUNCTION.
RX PubMed=12134085; DOI=10.1091/mbc.02-01-0005;
RA Bonangelino C.J., Chavez E.M., Bonifacino J.S.;
RT "Genomic screen for vacuolar protein sorting genes in Saccharomyces
RT cerevisiae.";
RL Mol. Biol. Cell 13:2486-2501(2002).
RN [4]
RP LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX PubMed=14562106; DOI=10.1038/nature02046;
RA Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA O'Shea E.K., Weissman J.S.;
RT "Global analysis of protein expression in yeast.";
RL Nature 425:737-741(2003).
CC -!- FUNCTION: Involved in vacuolar protein sorting.
CC {ECO:0000269|PubMed:12134085}.
CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass membrane protein.
CC -!- MISCELLANEOUS: Present with 623 molecules/cell in log phase SD medium.
CC {ECO:0000269|PubMed:14562106}.
CC -!- SIMILARITY: Belongs to the VPS62 family. {ECO:0000305}.
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DR EMBL; Z72926; CAA97154.1; -; Genomic_DNA.
DR EMBL; BK006941; DAA08232.1; -; Genomic_DNA.
DR PIR; S64450; S64450.
DR RefSeq; NP_011657.1; NM_001181270.1.
DR AlphaFoldDB; P53285; -.
DR BioGRID; 33387; 91.
DR DIP; DIP-5532N; -.
DR MINT; P53285; -.
DR STRING; 4932.YGR141W; -.
DR MaxQB; P53285; -.
DR PaxDb; P53285; -.
DR PRIDE; P53285; -.
DR EnsemblFungi; YGR141W_mRNA; YGR141W; YGR141W.
DR GeneID; 853042; -.
DR KEGG; sce:YGR141W; -.
DR SGD; S000003373; VPS62.
DR VEuPathDB; FungiDB:YGR141W; -.
DR eggNOG; ENOG502RJPB; Eukaryota.
DR GeneTree; ENSGT00940000176347; -.
DR HOGENOM; CLU_024079_2_0_1; -.
DR InParanoid; P53285; -.
DR OMA; MGYGPWG; -.
DR BioCyc; YEAST:G3O-30845-MON; -.
DR PRO; PR:P53285; -.
DR Proteomes; UP000002311; Chromosome VII.
DR RNAct; P53285; protein.
DR GO; GO:0005783; C:endoplasmic reticulum; HDA:SGD.
DR GO; GO:0000329; C:fungal-type vacuole membrane; HDA:SGD.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0006623; P:protein targeting to vacuole; HMP:SGD.
PE 1: Evidence at protein level;
KW Glycoprotein; Membrane; Protein transport; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..467
FT /note="Vacuolar protein sorting-associated protein 62"
FT /id="PRO_0000065906"
FT TRANSMEM 17..37
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CARBOHYD 74
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 145
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 467 AA; 54515 MW; D21C99972597E5C7 CRC64;
MRISKNSHKR QRTRLYFLVT FIIYSIIPCR AVLVPWLDDD PFEATLLEMG DEPWSKDILS
STPPLHPSEV TEDNKSLKQR GNVPQYVIDN SPLLHLYSEE KYWPADVKDF VKRFQLRDHS
GEKIINEHLR DLSDLQEYYS VELENGTWGR VSSEGTYMTS LDDFDKGPDW LLGEQPEYGT
GHIKKAPAVL FVVDKGNGWV DAFWFYFYPF NWGPYIMGSG PWGNHVGDWE HSLVRFYKGE
PQYLWMSAHG GGSAYKFEAI EKIKRLRRVD GKLTNEVIKK PLIFSARGTH AHYASVGQHA
HDVPFFFMPL SDFTDRGPLW DPSLNYYAYT VTVGEKMTPC GAEETKMGLE WLSFKGAWGD
KQLRPRDPRQ KWCPFQWKYI DGPKGPLFKN MERVSLCQRF KWWNFWKGCP ARRYIKRGEG
LDAEKNDLVG DNCGILLYNI RPKWLRSILR FLTWRGSVCF IMDYFTG
