VPS72_SCHPO
ID VPS72_SCHPO Reviewed; 316 AA.
AC Q9P790;
DT 10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 112.
DE RecName: Full=SWR complex protein 2;
GN Name=swc2; Synonyms=vps72; ORFNames=SPBP35G2.13c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-64 AND SER-65, AND
RP IDENTIFICATION BY MASS SPECTROMETRY.
RX PubMed=18257517; DOI=10.1021/pr7006335;
RA Wilson-Grady J.T., Villen J., Gygi S.P.;
RT "Phosphoproteome analysis of fission yeast.";
RL J. Proteome Res. 7:1088-1097(2008).
CC -!- FUNCTION: Participates in the catalytic exchange of histone H2A for the
CC H2A variant pht1, an euchromatin-specific factor, leading to chromatin
CC remodeling and changes in transcription of targeted genes.
CC {ECO:0000250}.
CC -!- SUBUNIT: Component of the SWR1 chromatin-remodeling complex.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16823372}.
CC -!- SIMILARITY: Belongs to the VPS72/YL1 family. {ECO:0000305}.
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DR EMBL; CU329671; CAB87375.1; -; Genomic_DNA.
DR RefSeq; NP_595388.1; NM_001021295.2.
DR AlphaFoldDB; Q9P790; -.
DR BioGRID; 277848; 136.
DR STRING; 4896.SPBP35G2.13c.1; -.
DR iPTMnet; Q9P790; -.
DR MaxQB; Q9P790; -.
DR PaxDb; Q9P790; -.
DR EnsemblFungi; SPBP35G2.13c.1; SPBP35G2.13c.1:pep; SPBP35G2.13c.
DR GeneID; 2541337; -.
DR KEGG; spo:SPBP35G2.13c; -.
DR PomBase; SPBP35G2.13c; swc2.
DR VEuPathDB; FungiDB:SPBP35G2.13c; -.
DR eggNOG; KOG2897; Eukaryota.
DR HOGENOM; CLU_883275_0_0_1; -.
DR InParanoid; Q9P790; -.
DR OMA; VNTKAYK; -.
DR PhylomeDB; Q9P790; -.
DR PRO; PR:Q9P790; -.
DR Proteomes; UP000002485; Chromosome II.
DR GO; GO:0072686; C:mitotic spindle; HDA:PomBase.
DR GO; GO:0005730; C:nucleolus; HDA:PomBase.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000812; C:Swr1 complex; IDA:PomBase.
DR GO; GO:0006338; P:chromatin remodeling; IPI:PomBase.
DR GO; GO:0043486; P:histone exchange; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; NAS:PomBase.
DR InterPro; IPR008895; Vps72/YL1.
DR InterPro; IPR013272; Vps72/YL1_C.
DR PANTHER; PTHR13275; PTHR13275; 1.
DR Pfam; PF05764; YL1; 1.
DR Pfam; PF08265; YL1_C; 1.
DR SMART; SM00993; YL1_C; 1.
PE 1: Evidence at protein level;
KW Chromatin regulator; Coiled coil; Nucleus; Phosphoprotein;
KW Reference proteome.
FT CHAIN 1..316
FT /note="SWR complex protein 2"
FT /id="PRO_0000339144"
FT REGION 1..81
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 93..127
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 153..180
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 20..95
FT /evidence="ECO:0000255"
FT COMPBIAS 16..41
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 42..64
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 65..81
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 64
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18257517"
FT MOD_RES 65
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18257517"
SQ SEQUENCE 316 AA; 36715 MW; 8D6C30620473FC52 CRC64;
MSATESLVAG RTRRANAGNK MRELLEKEHL RMTQQNAEIE KEDEEYNIEE EEEAERDIEI
SSESSDEEAE LKKLEEEGEE VEKILRDEER IKKRKIQKNR AANLQRTLQP PKRPTPSAAS
EVPKKKYKKI KVDPSARRTS SRMHTVLMAQ STETRLQEAK PRRKYTVSAS ANRQKGTMTQ
QQRFEEAAKT EAQNLSSLRN YVHLEEQRRL RLKRNAAKHR QLREPILKFI SKTISTEDGR
EASNYYVAPL EHPLCHSAPP LQMPQHRAVE CVITGKPAIY LDPVTQLPIS NVQAFQQVRE
VYNQRYSWSA MLNLFH
