ID   VPS72_XENLA             Reviewed;         353 AA.
AC   Q6GNJ8;
DT   30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 67.
DE   RecName: Full=Vacuolar protein sorting-associated protein 72 homolog;
DE   AltName: Full=Transcription factor-like 1;
GN   Name=vps72;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Deposition-and-exchange histone chaperone specific for H2AZ1,
CC       specifically chaperones H2AZ1 and deposits it into nucleosomes. As
CC       component of the SRCAP complex, mediates the ATP-dependent exchange of
CC       histone H2AZ1/H2B dimers for nucleosomal H2A/H2B, leading to
CC       transcriptional regulation of selected genes by chromatin remodeling.
CC       {ECO:0000250|UniProtKB:Q15906}.
CC   -!- SUBUNIT: Component of the NuA4 histone acetyltransferase complex.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the VPS72/YL1 family. {ECO:0000305}.
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DR   EMBL; BC073511; AAH73511.1; -; mRNA.
DR   RefSeq; NP_001085907.1; NM_001092438.1.
DR   AlphaFoldDB; Q6GNJ8; -.
DR   SMR; Q6GNJ8; -.
DR   BioGRID; 102497; 1.
DR   DNASU; 444334; -.
DR   GeneID; 444334; -.
DR   KEGG; xla:444334; -.
DR   CTD; 444334; -.
DR   Xenbase; XB-GENE-17339794; vps72.L.
DR   OrthoDB; 1468037at2759; -.
DR   Proteomes; UP000186698; Chromosome 8L.
DR   Bgee; 444334; Expressed in egg cell and 19 other tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0140713; F:histone chaperone activity; ISS:UniProtKB.
DR   GO; GO:0045815; P:epigenetic maintenance of chromatin in transcription-competent conformation; ISS:UniProtKB.
DR   GO; GO:0043486; P:histone exchange; IEA:InterPro.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   InterPro; IPR008895; Vps72/YL1.
DR   InterPro; IPR013272; Vps72/YL1_C.
DR   PANTHER; PTHR13275; PTHR13275; 1.
DR   Pfam; PF05764; YL1; 1.
DR   Pfam; PF08265; YL1_C; 1.
DR   SMART; SM00993; YL1_C; 1.
PE   2: Evidence at transcript level;
KW   Chromatin regulator; DNA-binding; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..353
FT                   /note="Vacuolar protein sorting-associated protein 72
FT                   homolog"
FT                   /id="PRO_0000239005"
FT   DNA_BIND        155..205
FT                   /evidence="ECO:0000255"
FT   REGION          1..143
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        41..72
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        73..98
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        116..143
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   353 AA;  40701 MW;  2928C69FAC2940F3 CRC64;
     MNLADGRAPR KTAGNRMSGL LQAEEEDDFY KTTYGGFNEE SGDEEYNEDR SASEDEVDSD
     FDIDEGDEPT SDHEEDEPKK KRRVVTKAYK EPIQLLKPKP KKPEAPPNTA AKSRPEKPQE
     PPDDTVDSRK QMRQSTTEHT RQTFLRVKER QIQSKKKKGP HLDRPLTQEE LLEEAKITEE
     INIRSLENYE RLEADRKKQV HKKRRCAGPT IRYHSMVMPL ITELRMKEEN VDVEGLDHEQ
     TDRTHAGKCS RSFITFSDDE TFERFFPRSK RGKFSVRDVC PVTHKPALYR DPITDIPYYN
     SKAFKIIRDA YKKYITTHGL PNAAMATTMG PSADAAQRNT RQKIIIKQSV PSA