ID   VPS_PSINU               Reviewed;         406 AA.
AC   Q9SLX9;
DT   03-APR-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   25-MAY-2022, entry version 69.
DE   RecName: Full=Phloroisovalerophenone synthase;
DE            Short=Valerophenone synthase;
DE            EC=2.3.1.156;
DE   AltName: Full=3-methyl-1-(trihydroxyphenyl)butan-1-one synthase;
GN   Name=VPS;
OS   Psilotum nudum (Whisk fern) (Lycopodium nudum).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Polypodiopsida; Ophioglossidae; Psilotales; Psilotaceae; Psilotum.
OX   NCBI_TaxID=3240;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Yamazaki Y., Sankawa U.;
RL   Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Produces 3-methyl-1-(2,4,6-trihydroxyphenyl)butan-1-one
CC       (phloroisovalerophenone).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=3-methylbutanoyl-CoA + 3 H(+) + 3 malonyl-CoA = 3 CO2 + 4 CoA
CC         + phlorisovalerophenone; Xref=Rhea:RHEA:23572, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:15951, ChEBI:CHEBI:16526, ChEBI:CHEBI:57287,
CC         ChEBI:CHEBI:57345, ChEBI:CHEBI:57384; EC=2.3.1.156;
CC   -!- SIMILARITY: Belongs to the thiolase-like superfamily. Chalcone/stilbene
CC       synthases family. {ECO:0000305}.
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DR   EMBL; AB022683; BAA87923.1; -; mRNA.
DR   AlphaFoldDB; Q9SLX9; -.
DR   SMR; Q9SLX9; -.
DR   GO; GO:0050634; F:phloroisovalerophenone synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR   Gene3D; 3.40.47.10; -; 2.
DR   InterPro; IPR012328; Chalcone/stilbene_synt_C.
DR   InterPro; IPR001099; Chalcone/stilbene_synt_N.
DR   InterPro; IPR018088; Chalcone/stilbene_synthase_AS.
DR   InterPro; IPR011141; Polyketide_synthase_type-III.
DR   InterPro; IPR016039; Thiolase-like.
DR   PANTHER; PTHR11877; PTHR11877; 1.
DR   Pfam; PF02797; Chal_sti_synt_C; 1.
DR   Pfam; PF00195; Chal_sti_synt_N; 1.
DR   PIRSF; PIRSF000451; PKS_III; 1.
DR   SUPFAM; SSF53901; SSF53901; 2.
DR   PROSITE; PS00441; CHALCONE_SYNTH; 1.
PE   2: Evidence at transcript level;
KW   Acyltransferase; Transferase.
FT   CHAIN           1..406
FT                   /note="Phloroisovalerophenone synthase"
FT                   /id="PRO_0000216086"
FT   ACT_SITE        171
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10023"
SQ   SEQUENCE   406 AA;  44562 MW;  CD5373D18114B2CB CRC64;
     MIQNSDSATA TLLPRKKERA SGPVSVLAIG SANPPNVFHQ SLFPDFYFNI TQSNHMAEVK
     AKFTRMCAKS GIKKRRMHIN EDILEAHPSI RSYHDNSLDV RQDMLVEEVP KLGKVAADNA
     IAEWGQPKSN ITHLIFCTSS GIDMPGADWA LMKLLGLRPT VNRVMVYQQG CFAGCTVLRI
     AKDLAENNKG SRILVVCSEL TLISFRGPTE DHPENLVGQA LFGDGAAALI VGADPIPHAE
     NASFEIHWAR SSVVPDSDDA VTGNIKENGL VLHLSKTIPD LIGQNIHTLL KDALEEMFDA
     CNPSSFNDLF WVIHPGGPAI LDAVEEELNL KSERTHASRE ILSQYGNMVS PGVLFVLDYM
     RKRSVDERLS TTGEGLEWGV MLGFGPGLTV ETLILKSVPT QAFKYF