VR100_RAT
ID VR100_RAT Reviewed; 326 AA.
AC Q5J3L6; Q62852;
DT 13-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 15-FEB-2005, sequence version 1.
DT 03-AUG-2022, entry version 93.
DE RecName: Full=Vomeronasal type-1 receptor 100;
DE AltName: Full=Pheromone receptor VN3;
DE AltName: Full=Vomeronasal receptor 3;
DE AltName: Full=Vomeronasal type-1 receptor A12;
GN Name=Vom1r100; Synonyms=V1ra12, Vnr3;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1] {ECO:0000305, ECO:0000312|EMBL:AAC52284.1}
RP NUCLEOTIDE SEQUENCE [MRNA], PUTATIVE FUNCTION, AND TISSUE SPECIFICITY.
RC STRAIN=Sprague-Dawley {ECO:0000312|EMBL:AAC52284.1};
RC TISSUE=Vomeronasal organ {ECO:0000312|EMBL:AAC52284.1};
RX PubMed=7585937; DOI=10.1016/0092-8674(95)90161-2;
RA Dulac C., Axel R.;
RT "A novel family of genes encoding putative pheromone receptors in
RT mammals.";
RL Cell 83:195-206(1995).
RN [2] {ECO:0000312|EMBL:AAR87961.1}
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Capello L., Rodriguez I.;
RT "Rat vomeronasal receptors.";
RL Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Putative pheromone receptor implicated in the regulation of
CC social as well as reproductive behavior. {ECO:0000250|UniProtKB:Q8VIC6,
CC ECO:0000269|PubMed:7585937}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- TISSUE SPECIFICITY: Expressed in 1-4% of neurons of the vomeronasal
CC organ. Only one pheromone receptor gene may be expressed in a
CC particular neuron. Not expressed in the main olfactory epithelium.
CC {ECO:0000269|PubMed:7585937}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; U36895; AAC52284.1; -; mRNA.
DR EMBL; AY510294; AAR87961.1; -; mRNA.
DR PIR; A57223; A57223.
DR RefSeq; NP_775418.1; NM_173296.1.
DR AlphaFoldDB; Q5J3L6; -.
DR SMR; Q5J3L6; -.
DR GlyGen; Q5J3L6; 1 site.
DR PaxDb; Q5J3L6; -.
DR Ensembl; ENSRNOT00000099837; ENSRNOP00000095102; ENSRNOG00000064314.
DR GeneID; 297439; -.
DR KEGG; rno:297439; -.
DR UCSC; RGD:1549727; rat.
DR CTD; 297439; -.
DR RGD; 1549727; Vom1r100.
DR eggNOG; ENOG502SNRJ; Eukaryota.
DR GeneTree; ENSGT01030000234553; -.
DR InParanoid; Q5J3L6; -.
DR OrthoDB; 1390012at2759; -.
DR PhylomeDB; Q5J3L6; -.
DR PRO; PR:Q5J3L6; -.
DR Proteomes; UP000002494; Chromosome 4.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016503; F:pheromone receptor activity; IEA:InterPro.
DR GO; GO:0019236; P:response to pheromone; IEA:UniProtKB-KW.
DR GO; GO:0007606; P:sensory perception of chemical stimulus; IEA:UniProt.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR004072; Vmron_rcpt_1.
DR PANTHER; PTHR24062; PTHR24062; 1.
DR Pfam; PF03402; V1R; 1.
DR PRINTS; PR01534; VOMERONASL1R.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Pheromone response; Receptor; Reference proteome; Transducer;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..326
FT /note="Vomeronasal type-1 receptor 100"
FT /id="PRO_0000239968"
FT TOPO_DOM 1..32
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 33..53
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 54..70
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 71..91
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 92..104
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 105..127
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 128..149
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 150..170
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 171..209
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 210..230
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 231..254
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 255..275
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 276..285
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 286..306
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 307..326
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 175
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 101..188
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT CONFLICT 1..15
FT /note="Missing (in Ref. 1; AAC52284)"
FT /evidence="ECO:0000305"
FT CONFLICT 28
FT /note="N -> T (in Ref. 1; AAC52284)"
FT /evidence="ECO:0000305"
FT CONFLICT 34
FT /note="F -> S (in Ref. 1; AAC52284)"
FT /evidence="ECO:0000305"
FT CONFLICT 224
FT /note="V -> E (in Ref. 1; AAC52284)"
FT /evidence="ECO:0000305"
FT CONFLICT 295
FT /note="Y -> D (in Ref. 1; AAC52284)"
FT /evidence="ECO:0000305"
FT CONFLICT 309
FT /note="E -> G (in Ref. 1; AAC52284)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 326 AA; 37396 MW; A5DFB076F4078BE2 CRC64;
MSEFPFFSPQ PLFSYMMNKN SRVHTDSNIR NTFFTEIGIG ILANSFLLLF HIFKFIRGQR
SRLTDLPIGL LSLIHLLMLL MGAFIAIDIF ISWRGWDDII CKFLVYLYRS FRGLSLCTTC
MLSVLQAITL SPRSSCLAKF KHKSPHHVSC AIISLSILYM FISSHLLVSI NATPNLTTNN
FMQVTQSCYI IPLSYLMQSM FSTLLAIRDI SLISLMVLST CYMVVLLCRH RNQIQHLQGT
NLSPKASPEQ RATQTILMLM TFFVLMSIFD SIVSCSRTMY LNDPTSYYIQ IFVVYIYATV
SPFVFMSTEK HIVNFLKSMC VRVKNV
