VR101_RAT
ID VR101_RAT Reviewed; 310 AA.
AC Q5J3M3; Q62851;
DT 13-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 15-FEB-2005, sequence version 1.
DT 03-AUG-2022, entry version 97.
DE RecName: Full=Vomeronasal type-1 receptor 101;
DE AltName: Full=Pheromone receptor VN7;
DE AltName: Full=Vomeronasal receptor 7;
DE AltName: Full=Vomeronasal type-1 receptor B13;
GN Name=Vom1r101; Synonyms=V1rb13, V1rb7 {ECO:0000312|RGD:708395};
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1] {ECO:0000312|EMBL:AAR87954.1}
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Capello L., Rodriguez I.;
RT "Rat vomeronasal receptors.";
RL Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000305, ECO:0000312|EMBL:AAA92008.1}
RP NUCLEOTIDE SEQUENCE [MRNA] OF 29-310, PUTATIVE FUNCTION, AND TISSUE
RP SPECIFICITY.
RC STRAIN=Sprague-Dawley {ECO:0000312|EMBL:AAA92008.1};
RC TISSUE=Vomeronasal organ {ECO:0000312|EMBL:AAA92008.1};
RX PubMed=7585937; DOI=10.1016/0092-8674(95)90161-2;
RA Dulac C., Axel R.;
RT "A novel family of genes encoding putative pheromone receptors in
RT mammals.";
RL Cell 83:195-206(1995).
CC -!- FUNCTION: Putative pheromone receptor implicated in the regulation of
CC social as well as reproductive behavior. {ECO:0000250|UniProtKB:Q8VIC6,
CC ECO:0000269|PubMed:7585937}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- TISSUE SPECIFICITY: Expressed in 1-4% of neurons of the vomeronasal
CC organ. Only one pheromone receptor gene may be expressed in a
CC particular neuron. Not expressed in the main olfactory epithelium.
CC {ECO:0000269|PubMed:7585937}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAA92008.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AY510287; AAR87954.1; -; mRNA.
DR EMBL; U36786; AAA92008.1; ALT_INIT; mRNA.
DR AlphaFoldDB; Q5J3M3; -.
DR SMR; Q5J3M3; -.
DR STRING; 10116.ENSRNOP00000047657; -.
DR GlyGen; Q5J3M3; 1 site.
DR PaxDb; Q5J3M3; -.
DR UCSC; RGD:708395; rat.
DR RGD; 708395; Vom1r101.
DR VEuPathDB; HostDB:ENSRNOG00000068663; -.
DR eggNOG; ENOG502SNRJ; Eukaryota.
DR HOGENOM; CLU_058641_0_0_1; -.
DR InParanoid; Q5J3M3; -.
DR OMA; MCKSAFY; -.
DR PhylomeDB; Q5J3M3; -.
DR PRO; PR:Q5J3M3; -.
DR Proteomes; UP000002494; Chromosome 4.
DR Genevisible; Q5J3M3; RN.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016503; F:pheromone receptor activity; IEA:InterPro.
DR GO; GO:0019236; P:response to pheromone; IEA:UniProtKB-KW.
DR GO; GO:0007606; P:sensory perception of chemical stimulus; IEA:UniProt.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR004072; Vmron_rcpt_1.
DR PANTHER; PTHR24062; PTHR24062; 1.
DR Pfam; PF03402; V1R; 1.
DR PRINTS; PR01534; VOMERONASL1R.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Pheromone response; Receptor; Reference proteome; Transducer;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..310
FT /note="Vomeronasal type-1 receptor 101"
FT /id="PRO_0000239984"
FT TOPO_DOM 1..19
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 20..40
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 41..49
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 50..70
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 71..93
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 94..114
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 115..134
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 135..155
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 156..193
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 194..214
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 215..238
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 239..259
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 260..268
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 269..289
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 290..310
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 159
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 85..172
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 310 AA; 35513 MW; 1AF5845F078B45BB CRC64;
MNKVNILPSD TNMKITLFSE LSVGISANSI LFFAHLCMFF EENRSKPIDL CIAFLSLTQL
MLLVTMGLIA ADMFMAQGIW DITTCRSLIY FHRLLRGFNL CAACLLHILW TFTLSPRSSC
LTKFKHKSPH HISGAYLFFC VLYMSFSSHL FVLVIATSNL TSDHFMYVTQ SCSLLPMSYS
RTSTFSLLMV TREVFLISLM ALSSGYMVTL LWRHKKQAQH LHSTRLSSKA SPQQRATRTI
LLLMTFFVVF YILGTVIFHS RTKFKDGSIF YCVQIIVSHS YATISPFVFV FSEKRIIKFF
RSMCGRIVNT
