VR102_RAT
ID VR102_RAT Reviewed; 336 AA.
AC Q5J3K5; Q62856;
DT 13-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 15-FEB-2005, sequence version 1.
DT 03-AUG-2022, entry version 93.
DE RecName: Full=Vomeronasal type-1 receptor 102;
DE AltName: Full=Pheromone receptor VN2;
DE AltName: Full=Vomeronasal receptor 2;
DE AltName: Full=Vomeronasal type-1 receptor A15;
GN Name=Vom1r102; Synonyms=V1ra15, Vnr2 {ECO:0000312|RGD:708384};
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1] {ECO:0000305, ECO:0000312|EMBL:AAC52288.1}
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), PUTATIVE FUNCTION, AND TISSUE
RP SPECIFICITY.
RC STRAIN=Sprague-Dawley {ECO:0000312|EMBL:AAC52288.1};
RC TISSUE=Vomeronasal organ {ECO:0000312|EMBL:AAC52288.1};
RX PubMed=7585937; DOI=10.1016/0092-8674(95)90161-2;
RA Dulac C., Axel R.;
RT "A novel family of genes encoding putative pheromone receptors in
RT mammals.";
RL Cell 83:195-206(1995).
RN [2] {ECO:0000305, ECO:0000312|EMBL:AAR87972.1}
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RA Capello L., Rodriguez I.;
RT "Rat vomeronasal receptors.";
RL Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Putative pheromone receptor implicated in the regulation of
CC social as well as reproductive behavior. {ECO:0000250|UniProtKB:Q8VIC6,
CC ECO:0000269|PubMed:7585937}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1 {ECO:0000269|Ref.2};
CC IsoId=Q5J3K5-1; Sequence=Displayed;
CC Name=2 {ECO:0000269|PubMed:7585937};
CC IsoId=Q5J3K5-2; Sequence=VSP_052065;
CC -!- TISSUE SPECIFICITY: Expressed in 1-4% of neurons of the vomeronasal
CC organ. Only one pheromone receptor gene may be expressed in a
CC particular neuron. Not expressed in the main olfactory epithelium.
CC {ECO:0000269|PubMed:7585937}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; U36899; AAC52288.1; -; mRNA.
DR EMBL; AY510305; AAR87972.1; -; mRNA.
DR PIR; I61749; I61749.
DR AlphaFoldDB; Q5J3K5; -.
DR SMR; Q5J3K5; -.
DR GlyGen; Q5J3K5; 1 site.
DR Ensembl; ENSRNOT00000052101; ENSRNOP00000039516; ENSRNOG00000055950. [Q5J3K5-2]
DR UCSC; RGD:708384; rat. [Q5J3K5-1]
DR RGD; 708384; Vom1r102.
DR GeneTree; ENSGT01030000234553; -.
DR InParanoid; Q5J3K5; -.
DR OrthoDB; 1390012at2759; -.
DR PhylomeDB; Q5J3K5; -.
DR PRO; PR:Q5J3K5; -.
DR Proteomes; UP000002494; Chromosome 4.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016503; F:pheromone receptor activity; IEA:InterPro.
DR GO; GO:0019236; P:response to pheromone; IEA:UniProtKB-KW.
DR GO; GO:0007606; P:sensory perception of chemical stimulus; IEA:UniProt.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR004072; Vmron_rcpt_1.
DR PANTHER; PTHR24062; PTHR24062; 1.
DR Pfam; PF03402; V1R; 1.
DR PRINTS; PR01534; VOMERONASL1R.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cell membrane; Disulfide bond;
KW G-protein coupled receptor; Glycoprotein; Membrane; Pheromone response;
KW Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..336
FT /note="Vomeronasal type-1 receptor 102"
FT /id="PRO_0000239971"
FT TOPO_DOM 1..42
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 43..63
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 64..75
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 76..96
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 97..120
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 121..140
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 141..157
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 158..178
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 179..213
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 214..234
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 235..264
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 265..285
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 286..296
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 297..317
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 318..336
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 185
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 111..198
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VAR_SEQ 1..20
FT /note="MVGVQICQGMTSEILFFSLQ -> MLSKK (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:7585937"
FT /id="VSP_052065"
FT CONFLICT 274
FT /note="V -> G (in Ref. 1; AAC52288)"
FT /evidence="ECO:0000305"
FT CONFLICT 283
FT /note="V -> A (in Ref. 1; AAC52288)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 336 AA; 38467 MW; C60B703FF7B8112F CRC64;
MVGVQICQGM TSEILFFSLQ PQFSNMMNKN SRLHIDSNIR NTFFTEIGIG VSANSLLLLF
NIFKFIHGQR SRLTDLPIGL LSLINLLMLL IMACIATDIF ISCRRWDDII CKSLLYLYRT
FRGLSLSTTC LLSVLQAIIL SPRSSCLAKY KHKPPHHIFC AMLFLSVLYM FISSHLLLSI
IATPNLTTND FIHVSQSCSI LPMSYLMQSM FSTLLAIRNV FLISLIVLST WYMVALLCRH
RKQTRHLQDT SLSRKASPEQ RATRSILMLR SLFVLMSIFD SIVSCSRTMY LNDPTSYSIQ
LLVVHIYATV SPFVFMITEK HIVNYLKSMY VRVLNV
