ID   VRAA_STAAR              Reviewed;         458 AA.
AC   Q6GJ94;
DT   25-OCT-2005, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 76.
DE   RecName: Full=Putative long chain fatty acid-CoA ligase VraA;
DE            EC=6.2.1.-;
DE   AltName: Full=Acyl-CoA synthetase;
GN   Name=vraA; OrderedLocusNames=SAR0580;
OS   Staphylococcus aureus (strain MRSA252).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=282458;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MRSA252;
RX   PubMed=15213324; DOI=10.1073/pnas.0402521101;
RA   Holden M.T.G., Feil E.J., Lindsay J.A., Peacock S.J., Day N.P.J.,
RA   Enright M.C., Foster T.J., Moore C.E., Hurst L., Atkin R., Barron A.,
RA   Bason N., Bentley S.D., Chillingworth C., Chillingworth T., Churcher C.,
RA   Clark L., Corton C., Cronin A., Doggett J., Dowd L., Feltwell T., Hance Z.,
RA   Harris B., Hauser H., Holroyd S., Jagels K., James K.D., Lennard N.,
RA   Line A., Mayes R., Moule S., Mungall K., Ormond D., Quail M.A.,
RA   Rabbinowitsch E., Rutherford K.M., Sanders M., Sharp S., Simmonds M.,
RA   Stevens K., Whitehead S., Barrell B.G., Spratt B.G., Parkhill J.;
RT   "Complete genomes of two clinical Staphylococcus aureus strains: evidence
RT   for the rapid evolution of virulence and drug resistance.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:9786-9791(2004).
CC   -!- SIMILARITY: Belongs to the ATP-dependent AMP-binding enzyme family.
CC       {ECO:0000305}.
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DR   EMBL; BX571856; CAG39600.1; -; Genomic_DNA.
DR   RefSeq; WP_000382590.1; NC_002952.2.
DR   AlphaFoldDB; Q6GJ94; -.
DR   SMR; Q6GJ94; -.
DR   KEGG; sar:SAR0580; -.
DR   HOGENOM; CLU_000022_59_0_9; -.
DR   OMA; WFESVCK; -.
DR   OrthoDB; 377638at2; -.
DR   Proteomes; UP000000596; Chromosome.
DR   GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006631; P:fatty acid metabolic process; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.300.30; -; 1.
DR   Gene3D; 3.40.50.12780; -; 1.
DR   InterPro; IPR025110; AMP-bd_C.
DR   InterPro; IPR045851; AMP-bd_C_sf.
DR   InterPro; IPR020845; AMP-binding_CS.
DR   InterPro; IPR000873; AMP-dep_Synth/Lig.
DR   InterPro; IPR042099; ANL_N_sf.
DR   Pfam; PF00501; AMP-binding; 1.
DR   Pfam; PF13193; AMP-binding_C; 1.
DR   PROSITE; PS00455; AMP_BINDING; 1.
PE   3: Inferred from homology;
KW   Fatty acid metabolism; Ligase; Lipid metabolism.
FT   CHAIN           1..458
FT                   /note="Putative long chain fatty acid-CoA ligase VraA"
FT                   /id="PRO_0000193194"
SQ   SEQUENCE   458 AA;  52126 MW;  A5056D317277168F CRC64;
     MDVILEQLET HTQNKPNDIA LHIDDETITY SQLNARITSA VESLQKYSLN PVVAINMKSP
     VQSIICYLAL HRLHKVPMMM EGKWQSTIHR QLIEKYGIKD VIGDTCLMQN IDSPMFIDST
     QLQHYPNLLH IGFTSGTTGL PKAYYRDEDS WLASFEVNEM LMLKNENAIA APGPLSHSLT
     LYALLFALSS GRTFIGQTTF HPERLLNQCR KISSYKVAMF LVPTMIKSLL LVYNNEHTIQ
     SFFSSGDKLY SSIFKKIKNQ ANDINLIEFF GTSETSFISY NLNQQAPVES VGVLFPNVEL
     KTTNHDHNGI GTICVKSNMM FSGYVSEQCI NNDEWFVTND NGYVKEQYLY LTGRQHDMLI
     IGGQNIYPAH VERLLTQSSS IDEAIIIGIP NERFGQIGVL LYSGDVTLTH KNVKQFLNKK
     VKRYEIPSMI HHVEKMYYTA SGKIAREKMM SMYLRGEL