ID   VRAA_STAAW              Reviewed;         458 AA.
AC   Q7A1Q0;
DT   25-OCT-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 81.
DE   RecName: Full=Putative long chain fatty acid-CoA ligase VraA;
DE            EC=6.2.1.-;
DE   AltName: Full=Acyl-CoA synthetase;
GN   Name=vraA; OrderedLocusNames=MW0530;
OS   Staphylococcus aureus (strain MW2).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=196620;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MW2;
RX   PubMed=12044378; DOI=10.1016/s0140-6736(02)08713-5;
RA   Baba T., Takeuchi F., Kuroda M., Yuzawa H., Aoki K., Oguchi A., Nagai Y.,
RA   Iwama N., Asano K., Naimi T., Kuroda H., Cui L., Yamamoto K., Hiramatsu K.;
RT   "Genome and virulence determinants of high virulence community-acquired
RT   MRSA.";
RL   Lancet 359:1819-1827(2002).
CC   -!- SIMILARITY: Belongs to the ATP-dependent AMP-binding enzyme family.
CC       {ECO:0000305}.
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DR   EMBL; BA000033; BAB94395.1; -; Genomic_DNA.
DR   RefSeq; WP_001100835.1; NC_003923.1.
DR   AlphaFoldDB; Q7A1Q0; -.
DR   SMR; Q7A1Q0; -.
DR   EnsemblBacteria; BAB94395; BAB94395; BAB94395.
DR   KEGG; sam:MW0530; -.
DR   HOGENOM; CLU_000022_59_0_9; -.
DR   OMA; WFESVCK; -.
DR   Proteomes; UP000000418; Chromosome.
DR   GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006631; P:fatty acid metabolic process; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.300.30; -; 1.
DR   Gene3D; 3.40.50.12780; -; 1.
DR   InterPro; IPR025110; AMP-bd_C.
DR   InterPro; IPR045851; AMP-bd_C_sf.
DR   InterPro; IPR020845; AMP-binding_CS.
DR   InterPro; IPR000873; AMP-dep_Synth/Lig.
DR   InterPro; IPR042099; ANL_N_sf.
DR   Pfam; PF00501; AMP-binding; 1.
DR   Pfam; PF13193; AMP-binding_C; 1.
DR   PROSITE; PS00455; AMP_BINDING; 1.
PE   3: Inferred from homology;
KW   Fatty acid metabolism; Ligase; Lipid metabolism.
FT   CHAIN           1..458
FT                   /note="Putative long chain fatty acid-CoA ligase VraA"
FT                   /id="PRO_0000193196"
SQ   SEQUENCE   458 AA;  52024 MW;  0843B823F1F5267B CRC64;
     MNVILEQLKT HTQNKPNDIA LHIDDETITY SQLNARITSA VESLQKYSLN PVVAINMKSP
     VQSIICYLAL HRLHKVPMMM EGKWQSTIHR QLIEKYGIKD VIGDTGLMQN IDSPMFIDST
     QLQHYPNLLH IGFTSGTTGL PKAYYRDEDS WLASFEVNEM LMLKNENAIA APGPLSHSLT
     LYALLFALSS GRTFIGQTTF HPEKLLNQCH KISSYKVAMF LVPTMIKSLL LVYNNEHTIQ
     SFFSSGDKLH SSIFKKIKNQ ANDINLIEFF GTSETSFISY NLNQQAPVES VGVLFPNVEL
     KTTNHDHNGI GTICIKSNMM FSGYVSEQCI NNDEWFVTND NGYVKEQYLY LTGRQQDMLI
     IGGQNIYPAH VERLLTQSSS IDEAIIIGIP NERFGQIGVL LYSGDVTLTH KNVKQFLKKK
     VKRYEIPSMI HHVEKMYYTA SGKIAREKMM SMYLRGEL