ID   VRAA_STAHJ              Reviewed;         461 AA.
AC   Q4L3Q0;
DT   25-OCT-2005, integrated into UniProtKB/Swiss-Prot.
DT   02-AUG-2005, sequence version 1.
DT   25-MAY-2022, entry version 98.
DE   RecName: Full=Putative long chain fatty acid-CoA ligase VraA;
DE            EC=6.2.1.-;
DE   AltName: Full=Acyl-CoA synthetase;
GN   Name=vraA; OrderedLocusNames=SH2418;
OS   Staphylococcus haemolyticus (strain JCSC1435).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=279808;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JCSC1435;
RX   PubMed=16237012; DOI=10.1128/jb.187.21.7292-7308.2005;
RA   Takeuchi F., Watanabe S., Baba T., Yuzawa H., Ito T., Morimoto Y.,
RA   Kuroda M., Cui L., Takahashi M., Ankai A., Baba S., Fukui S., Lee J.C.,
RA   Hiramatsu K.;
RT   "Whole-genome sequencing of Staphylococcus haemolyticus uncovers the
RT   extreme plasticity of its genome and the evolution of human-colonizing
RT   staphylococcal species.";
RL   J. Bacteriol. 187:7292-7308(2005).
CC   -!- SIMILARITY: Belongs to the ATP-dependent AMP-binding enzyme family.
CC       {ECO:0000305}.
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DR   EMBL; AP006716; BAE05727.1; -; Genomic_DNA.
DR   RefSeq; WP_011276673.1; NC_007168.1.
DR   AlphaFoldDB; Q4L3Q0; -.
DR   SMR; Q4L3Q0; -.
DR   STRING; 279808.SH2418; -.
DR   EnsemblBacteria; BAE05727; BAE05727; SH2418.
DR   KEGG; sha:SH2418; -.
DR   eggNOG; COG0318; Bacteria.
DR   HOGENOM; CLU_000022_59_0_9; -.
DR   OMA; WFESVCK; -.
DR   OrthoDB; 377638at2; -.
DR   Proteomes; UP000000543; Chromosome.
DR   GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006631; P:fatty acid metabolic process; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.300.30; -; 1.
DR   Gene3D; 3.40.50.12780; -; 1.
DR   InterPro; IPR025110; AMP-bd_C.
DR   InterPro; IPR045851; AMP-bd_C_sf.
DR   InterPro; IPR020845; AMP-binding_CS.
DR   InterPro; IPR000873; AMP-dep_Synth/Lig.
DR   InterPro; IPR042099; ANL_N_sf.
DR   Pfam; PF00501; AMP-binding; 1.
DR   Pfam; PF13193; AMP-binding_C; 1.
DR   PROSITE; PS00455; AMP_BINDING; 1.
PE   3: Inferred from homology;
KW   Fatty acid metabolism; Ligase; Lipid metabolism.
FT   CHAIN           1..461
FT                   /note="Putative long chain fatty acid-CoA ligase VraA"
FT                   /id="PRO_0000193199"
SQ   SEQUENCE   461 AA;  52631 MW;  34949F729441C0B6 CRC64;
     MLEIIKRLEY YAKVQPQSIA LQIDDEIVNY ENLYQKICDC TLNSPKFKLG CRVALLNDSP
     IVNITNYFVV LMMDGVPCFL DNKWSRDTID KLIEHFHIEY VMTAIGKFKR TTSFGTYEKY
     ISEQLKVDDL LHIGFTSGTT GLPKAYYRNE PSWIASYVEN EKLIYNYEKA LAAPGPLAHS
     LSLYTCIYAL YSGRTFIGQR QFDAKRFISI LNEQHSNIAL FLVPTMLHQL LNVDTTITHI
     KSIFCSGAKL SESLFKTVSQ QFKNANIIEF FGTSEASFIT YNFNQTSPTN SVGQVFPNVS
     IKLEAQDNRK IGLLKVQSNM IYSGYVDVGV VQPHSWIETG DYAYIQNNQL YLVSRKSDRL
     IIGGKNIYPN VIEQQVKSLD GIEEAVVVGE PHRRFGEIAV LIYVGNQELD YTTLRRYLRQ
     TLSRYEIPSK LVRVKDLPFT NSGKVARNTV QTLYLEGAFK V