VRAS_STAHJ
ID VRAS_STAHJ Reviewed; 348 AA.
AC Q4L7J6;
DT 07-FEB-2006, integrated into UniProtKB/Swiss-Prot.
DT 02-AUG-2005, sequence version 1.
DT 25-MAY-2022, entry version 121.
DE RecName: Full=Sensor protein VraS;
DE EC=2.7.13.3;
GN Name=vraS; OrderedLocusNames=SH1070;
OS Staphylococcus haemolyticus (strain JCSC1435).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=279808;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JCSC1435;
RX PubMed=16237012; DOI=10.1128/jb.187.21.7292-7308.2005;
RA Takeuchi F., Watanabe S., Baba T., Yuzawa H., Ito T., Morimoto Y.,
RA Kuroda M., Cui L., Takahashi M., Ankai A., Baba S., Fukui S., Lee J.C.,
RA Hiramatsu K.;
RT "Whole-genome sequencing of Staphylococcus haemolyticus uncovers the
RT extreme plasticity of its genome and the evolution of human-colonizing
RT staphylococcal species.";
RL J. Bacteriol. 187:7292-7308(2005).
CC -!- FUNCTION: Member of the two-component regulatory system VraS/VraR
CC involved in the control of the cell wall peptidoglycan biosynthesis.
CC Probably activates VraR by phosphorylation (By similarity).
CC {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC histidine.; EC=2.7.13.3;
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
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DR EMBL; AP006716; BAE04379.1; -; Genomic_DNA.
DR RefSeq; WP_011275375.1; NC_007168.1.
DR AlphaFoldDB; Q4L7J6; -.
DR SMR; Q4L7J6; -.
DR STRING; 279808.SH1070; -.
DR EnsemblBacteria; BAE04379; BAE04379; SH1070.
DR GeneID; 58062756; -.
DR KEGG; sha:SH1070; -.
DR eggNOG; COG4585; Bacteria.
DR HOGENOM; CLU_000445_20_12_9; -.
DR OMA; FPDYCRQ; -.
DR OrthoDB; 1755994at2; -.
DR Proteomes; UP000000543; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR Gene3D; 3.30.565.10; -; 1.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR017202; LiaS/VraS.
DR InterPro; IPR011712; Sig_transdc_His_kin_sub3_dim/P.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF07730; HisKA_3; 1.
DR PIRSF; PIRSF037431; STHK_LiaS; 1.
DR SMART; SM00387; HATPase_c; 1.
DR SUPFAM; SSF55874; SSF55874; 1.
PE 3: Inferred from homology;
KW ATP-binding; Cell membrane; Kinase; Membrane; Nucleotide-binding;
KW Phosphoprotein; Transferase; Transmembrane; Transmembrane helix;
KW Two-component regulatory system.
FT CHAIN 1..348
FT /note="Sensor protein VraS"
FT /id="PRO_0000074907"
FT TRANSMEM 13..33
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 43..63
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 150..341
FT /note="Histidine kinase"
SQ SEQUENCE 348 AA; 40180 MW; 6801EEC340E4C078 CRC64;
MNHYLRAIGS MLILVYSMLT AFLFIDKVFV NIIYFQGMFY TQIFGIPVFL FLNLVIILLC
IIVGSILAYK INQQNQWIKS QIEHAIEGET VGINDQNIEL YNETIDLYQT LVPLNQELHR
LRMKTQNLTN ENYNMNDVKV KKIIENERQR LARELHDSVS QQLFAASMML SAIKETKLEA
PLDQQIPVLE KMVQESQLEM RALLLHLRPL GLKDKSLGEG IKDLVIDLQK KVPMKVIHDI
QDFKVPKGIE DHLFRITQEA ISNTLRHSNG TKVTVELFNQ QDYLLLRIQD NGKGFNVDEK
LEQSYGLKNM RERALEIGAT FHIVSLPDSG TRIEVKAPLN REDDNNDD