VRPR_SALTY
ID VRPR_SALTY Reviewed; 297 AA.
AC P13041;
DT 01-JAN-1990, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1990, sequence version 1.
DT 03-AUG-2022, entry version 141.
DE RecName: Full=Virulence genes transcriptional activator;
GN Name=mkaC; Synonyms=mkfC, spvR, vagA; OrderedLocusNames=PSLT041;
OS Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OG Plasmid pEX102, Plasmid pStSR100, Plasmid pIP1350, and Plasmid pSLT.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Salmonella.
OX NCBI_TaxID=99287;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=1275 wild-type; PLASMID=pEX102;
RX PubMed=2798139; DOI=10.1093/nar/17.19.7983;
RA Pullinger G.D., Baird G.D., Williamson C.M., Lax A.J.;
RT "Nucleotide sequence of a plasmid gene involved in the virulence of
RT salmonellas.";
RL Nucleic Acids Res. 17:7983-7983(1989).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC PLASMID=pEX102;
RX PubMed=2684688; DOI=10.1016/0014-5793(89)81551-0;
RA Taira S., Rhen M.;
RT "Molecular organization of genes constituting the virulence determinant on
RT the Salmonella typhimurium 96 kilobase pair plasmid.";
RL FEBS Lett. 257:274-278(1989).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=SR-11; PLASMID=pStSR100;
RX PubMed=1657882; DOI=10.1128/jb.173.22.7176-7185.1991;
RA Caldweel A.L., Gulig P.A.;
RT "The Salmonella typhimurium virulence plasmid encodes a positive regulator
RT of a plasmid-encoded virulence gene.";
RL J. Bacteriol. 173:7176-7185(1991).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=C5; PLASMID=pIP1350;
RX PubMed=2697048; DOI=10.1016/0923-2508(89)90194-0;
RA Norel F., Pisano M.-R., Nicoli J., Popoff M.Y.;
RT "A plasmid-borne virulence region (2.8 kb) from Salmonella typhimurium
RT contains two open reading frames.";
RL Res. Microbiol. 140:627-630(1989).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LT2 / SGSC1412 / ATCC 700720; PLASMID=pSLT;
RX PubMed=11677609; DOI=10.1038/35101614;
RA McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA Wilson R.K.;
RT "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL Nature 413:852-856(2001).
RN [6]
RP PROTEIN SEQUENCE OF 1-10.
RC PLASMID=pEX102;
RX PubMed=2037236; DOI=10.1016/0378-1097(91)90573-s;
RA Taira S., Baumann M., Riikonen P., Sukupolvi S., Rhen M.;
RT "Amino-terminal sequence analysis of four plasmid-encoded virulence-
RT associated proteins of Salmonella typhimurium.";
RL FEMS Microbiol. Lett. 77:319-323(1991).
CC -!- FUNCTION: Positive regulator for the plasmid-encoded virulence factors
CC SpvA, SpvB, and SpvC.
CC -!- SUBCELLULAR LOCATION: Cytoplasm.
CC -!- SIMILARITY: Belongs to the LysR transcriptional regulatory family.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; X16111; CAA34244.1; -; Genomic_DNA.
DR EMBL; X57092; CAA40371.1; -; Genomic_DNA.
DR EMBL; AE006471; AAL23532.1; -; Genomic_DNA.
DR PIR; S06670; S06670.
DR RefSeq; NP_490531.1; NC_003277.2.
DR RefSeq; WP_000346691.1; NC_003277.2.
DR RefSeq; YP_003264394.1; NC_013437.1.
DR RefSeq; YP_003864191.1; NC_014476.2.
DR RefSeq; YP_006955263.1; NC_019108.1.
DR RefSeq; YP_006955403.1; NC_019109.1.
DR RefSeq; YP_006955579.1; NC_019001.1.
DR AlphaFoldDB; P13041; -.
DR SMR; P13041; -.
DR EnsemblBacteria; AAL23532; AAL23532; PSLT041.
DR GeneID; 1256197; -.
DR KEGG; stm:PSLT041; -.
DR PATRIC; fig|99287.12.peg.4894; -.
DR HOGENOM; CLU_936543_0_0_6; -.
DR OMA; VISARHY; -.
DR PhylomeDB; P13041; -.
DR BioCyc; SENT99287:PSLT041-MON; -.
DR PHI-base; PHI:2671; -.
DR PHI-base; PHI:662; -.
DR Proteomes; UP000001014; Plasmid pSLT.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR000847; Tscrpt_reg_HTH_LysR.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR Pfam; PF00126; HTH_1; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR PROSITE; PS50931; HTH_LYSR; 1.
PE 1: Evidence at protein level;
KW Activator; Cytoplasm; Direct protein sequencing; DNA-binding; Plasmid;
KW Reference proteome; Transcription; Transcription regulation; Virulence.
FT CHAIN 1..297
FT /note="Virulence genes transcriptional activator"
FT /id="PRO_0000105680"
FT DOMAIN 1..61
FT /note="HTH lysR-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
FT DNA_BIND 21..40
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
SQ SEQUENCE 297 AA; 33836 MW; 7741E6E79BB959C3 CRC64;
MDFLINKKLK IFITLMETGS FSIATSVLYI TRTPLSRVIS DLERELKQRL FIRKNGTLIP
TEFAQTIYRK VKSHYIFLHA LEQEIGPTGK TKQLEIIFDE IYPGSLKNLI ISALTISGQK
TNIMGRAVNS QIIEELCQTN NCIVISARNY FHRESLVCRT SVEGGVMLFI PKKFFLCGKP
DINRLAGTPV LFHEGAKNFN LDTIYHFFEQ TLGITNPAFS FDNVDLFSSL YRLQQGLAML
LIPVRVCRAL GLSTDHALHI KGVALCTSLY YPTKKRETPD YRKAIKLIQQ ELKQSTF
