ID   VRTN_DANRE              Reviewed;         677 AA.
AC   Q08C99; A5PMA1; B0R0J2;
DT   20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT   31-OCT-2006, sequence version 1.
DT   03-AUG-2022, entry version 61.
DE   RecName: Full=Vertnin;
GN   Name=vrtn; ORFNames=si:ch211-146n9.1, si:dkey-1h6.4, zgc:153349;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen;
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA   Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA   Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA   White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA   Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA   Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA   Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA   Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA   Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA   Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA   Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA   McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA   Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA   Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA   Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA   Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA   Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA   Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA   Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA   Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA   Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA   Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA   de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA   Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the human
RT   genome.";
RL   Nature 496:498-503(2013).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Ovary;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the vertnin family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AL928790; CAQ15258.1; -; Genomic_DNA.
DR   EMBL; BX255917; CAN88290.1; -; Genomic_DNA.
DR   EMBL; BC124324; AAI24325.1; -; mRNA.
DR   RefSeq; NP_001070608.1; NM_001077140.1.
DR   AlphaFoldDB; Q08C99; -.
DR   STRING; 7955.ENSDARP00000083446; -.
DR   PaxDb; Q08C99; -.
DR   PRIDE; Q08C99; -.
DR   GeneID; 555269; -.
DR   KEGG; dre:555269; -.
DR   CTD; 55237; -.
DR   ZFIN; ZDB-GENE-060929-700; vrtn.
DR   eggNOG; ENOG502SC23; Eukaryota.
DR   InParanoid; Q08C99; -.
DR   OrthoDB; 570582at2759; -.
DR   PhylomeDB; Q08C99; -.
DR   TreeFam; TF332015; -.
DR   PRO; PR:Q08C99; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0000785; C:chromatin; IDA:ZFIN.
DR   GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IDA:ZFIN.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IDA:ZFIN.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   InterPro; IPR038822; Vertnin-like.
DR   PANTHER; PTHR16081; PTHR16081; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome.
FT   CHAIN           1..677
FT                   /note="Vertnin"
FT                   /id="PRO_0000360410"
FT   REGION          356..376
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          458..490
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        37
FT                   /note="V -> A (in Ref. 1; CAN88290)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        107
FT                   /note="A -> T (in Ref. 1; CAN88290/CAQ15258)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        570
FT                   /note="I -> V (in Ref. 1; CAN88290)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        606
FT                   /note="P -> R (in Ref. 1; CAN88290)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   677 AA;  77732 MW;  C2DF8C857776D803 CRC64;
     MIQRAEAVLS VLGELQEATE CVGLDALTKV AVEVEQVLAP FPLPTAPCSE ISSWQGIDAV
     AHRLYPGDAP TGLLPLVCKG EGNLLFDAAS MLLVGSTSLS LELQVRAVVE MLIWKRYYLC
     GMIDSKVMLQ AARFSLCAEE SQDMLNLPIQ VLEAIFDADV KASCFHGSFA NMWHVYALAS
     VLQCNIYSVY PMYNLKIRPY FNRLIRPRIW SKDTEPLTLH IMWSGDLEAG SVFKPHKFVA
     LIHASDLKIG SPNSEQRMPL VKSLELQNQD TQLSYSNLKN KFNITKSTFY RWKRQSIEYH
     KKSVARYEAK HFFLTSYKQG KLIPLSQFKE LFPEIPRSTY YAWKQELVSC CSLSGGSTGE
     LSPGDSTEQD YWSSPEVKKT PGQGSFANML AFKYEKLEGE RNQNVTLMQE AKKSLQDCIV
     ANTSFPYRIF KRKFPGISRS TYYNWRREAM LFIPFKEHSG SSEEGSDADK SQSPRSQMSP
     SKFDRQKLSP RVRISRRKHR SLRLAYHHRK MLREEAKMHI RRSKMSFIKF KLKFPTVSSS
     FYWLWRVSLN RKPEKPAVMS NSEESKSLAI SPDVFQKIKT QGMFSFDGNI DCLNGQTEFT
     MPEYSPPDQS TNDHMFVMDV VALANFKAKA KLFLQQRFEE KAFPTFKEFR SYFPLTPRST
     YYMWKRALHH GVPLIHA