VRTR1_PENAE
ID VRTR1_PENAE Reviewed; 715 AA.
AC D7PI00;
DT 06-JUL-2016, integrated into UniProtKB/Swiss-Prot.
DT 10-AUG-2010, sequence version 1.
DT 25-MAY-2022, entry version 42.
DE RecName: Full=Transcription factor vrtR1 {ECO:0000303|PubMed:20534346};
DE AltName: Full=Viridicatumtoxin synthesis protein R1 {ECO:0000303|PubMed:20534346};
GN Name=vrtR1 {ECO:0000303|PubMed:20534346};
OS Penicillium aethiopicum.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium.
OX NCBI_TaxID=36650;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RC STRAIN=IBT 5753;
RX PubMed=20534346; DOI=10.1016/j.chembiol.2010.03.015;
RA Chooi Y.H., Cacho R., Tang Y.;
RT "Identification of the viridicatumtoxin and griseofulvin gene clusters from
RT Penicillium aethiopicum.";
RL Chem. Biol. 17:483-494(2010).
RN [2]
RP BIOTECHNOLOGY.
RX PubMed=19168978; DOI=10.1038/ja.2008.84;
RA Zheng C.J., Yu H.E., Kim E.H., Kim W.G.;
RT "Viridicatumtoxin B, a new anti-MRSA agent from Penicillium sp. FR11.";
RL J. Antibiot. 61:633-637(2008).
RN [3]
RP BIOTECHNOLOGY.
RX PubMed=27049441; DOI=10.1038/ja.2016.35;
RA Inokoshi J., Nakamura Y., Komada S., Komatsu K., Umeyama H., Tomoda H.;
RT "Inhibition of bacterial undecaprenyl pyrophosphate synthase by small
RT fungal molecules.";
RL J. Antibiot. 69:798-805(2016).
CC -!- FUNCTION: Probable transcription factor that regulates expression of
CC the gene cluster that mediates the biosynthesis of viridicatumtoxin, a
CC tetracycline-like fungal meroterpenoid with a unique, fused
CC spirobicyclic ring system (PubMed:20534346).
CC {ECO:0000269|PubMed:20534346}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00227}.
CC -!- BIOTECHNOLOGY: Viridicatumtoxin and its derivative, viridicatumtoxin B,
CC exhibit anti-methicillin-resistant Staphylococcus aureus (anti-MRSA)
CC activity (PubMed:19168978). Moreover, viridicatumtoxin and a C2 acetyl
CC analog, spirohexaline, have been demonstrated to inhibit bacterial
CC undecaprenyl diphosphate synthase, a potential new target for
CC antibiotic development (PubMed:27049441). {ECO:0000269|PubMed:19168978,
CC ECO:0000269|PubMed:27049441}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; GU574477; ADI24933.1; -; Genomic_DNA.
DR AlphaFoldDB; D7PI00; -.
DR SMR; D7PI00; -.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
DR CDD; cd00067; GAL4; 1.
DR Gene3D; 4.10.240.10; -; 1.
DR InterPro; IPR007219; Transcription_factor_dom_fun.
DR InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR Pfam; PF04082; Fungal_trans; 1.
DR Pfam; PF00172; Zn_clus; 1.
DR SMART; SM00906; Fungal_trans; 1.
DR SMART; SM00066; GAL4; 1.
DR SUPFAM; SSF57701; SSF57701; 1.
DR PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE 1: Evidence at protein level;
KW DNA-binding; Metal-binding; Nucleus; Transcription;
KW Transcription regulation; Zinc.
FT CHAIN 1..715
FT /note="Transcription factor vrtR1"
FT /id="PRO_0000436817"
FT DNA_BIND 51..78
FT /note="Zn(2)-C6 fungal-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
FT REGION 119..144
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 119..141
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 715 AA; 80128 MW; 3C145FA9F0E8941B CRC64;
MEDTTETTET TDTTAVSRLV PLAPAPARAP SMDAVNGSFD SELTTARRFN CQSCVRKKIK
CNRAVPTCAS CSKAKLHCVY QSRPPRKRKR SRGEEDVYER LAQYERILHD HNLLQAAAAS
TPSGRDTETS AISTRAPTPV LPDAQTHTKA GKVLLSTDGR SRYIDNVLLL DAGEGDLCEL
PESEQEDYNH DETSPDESTP TGLLGALAAH TISGAIIGNT QSLTNLHPTY EQAAKLWQAY
VKNVEPLCKI LHVPTVAKMF DTVSKQPAAV SKNDECLMFV IYYFAVFSMS DDECLHEFNY
PRAQLLSRYQ TTVIQALVNA SWLKTTAMPV LQAYTLFLIA LRTQIDSHTF WILTGIAVRL
AQRMGLHRDG ESLGLPPFEV QMRRRLFWQL LPLDSYAGQT SGTGISISPS SWDTKQPLNI
NDDQIFPGMT QPPCEQRGAS EMIFCLSRME LSNFYIRTGV KLKEHGDTIQ FRDAEDIERL
IDEVEDLIET KFLRYCDILN PLHFLTTGIV RSAIDAVRLR ARMPLLKQQT ITDAQRRRLC
ALAEKVLDTN STIFSNPSTQ NFRWQMQAFF LWDALLCILR NIAEVGFYSP SELAAAWSKV
ANVYANHDEL VKARRTLYVT IAKVTLKAWL ANPPRDSSPQ PAFITALLTQ HEPKGINQQQ
NSVLSDDKAA DGASLFDEFF DNMNGTDLDI NNAFNLDSSS DWLFWDQICR GTSLS