VS10L_MOUSE
ID VS10L_MOUSE Reviewed; 868 AA.
AC D3YZF7; D3YWE2;
DT 15-JUN-2010, integrated into UniProtKB/Swiss-Prot.
DT 20-APR-2010, sequence version 1.
DT 03-AUG-2022, entry version 68.
DE RecName: Full=V-set and immunoglobulin domain-containing protein 10-like;
DE Flags: Precursor;
GN Name=Vsig10l;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
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DR EMBL; AC154108; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS90217.1; -.
DR RefSeq; XP_355890.5; XM_355890.10.
DR AlphaFoldDB; D3YZF7; -.
DR STRING; 10090.ENSMUSP00000103611; -.
DR GlyGen; D3YZF7; 7 sites.
DR PhosphoSitePlus; D3YZF7; -.
DR PaxDb; D3YZF7; -.
DR PRIDE; D3YZF7; -.
DR ProteomicsDB; 297547; -.
DR Antibodypedia; 71769; 8 antibodies from 4 providers.
DR Ensembl; ENSMUST00000107977; ENSMUSP00000103611; ENSMUSG00000070604.
DR UCSC; uc009gmu.2; mouse.
DR MGI; MGI:1922940; Vsig10l.
DR VEuPathDB; HostDB:ENSMUSG00000070604; -.
DR eggNOG; ENOG502QWIT; Eukaryota.
DR GeneTree; ENSGT00940000162314; -.
DR HOGENOM; CLU_015581_0_0_1; -.
DR InParanoid; D3YZF7; -.
DR OrthoDB; 765840at2759; -.
DR PhylomeDB; D3YZF7; -.
DR TreeFam; TF334050; -.
DR BioGRID-ORCS; 75690; 0 hits in 2 CRISPR screens.
DR ChiTaRS; Vsig10l; mouse.
DR PRO; PR:D3YZF7; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; D3YZF7; protein.
DR Bgee; ENSMUSG00000070604; Expressed in esophagus and 62 other tissues.
DR ExpressionAtlas; D3YZF7; baseline and differential.
DR Genevisible; D3YZF7; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR Gene3D; 2.60.40.10; -; 4.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR Pfam; PF13895; Ig_2; 1.
DR SMART; SM00409; IG; 3.
DR SMART; SM00408; IGc2; 2.
DR SUPFAM; SSF48726; SSF48726; 4.
DR PROSITE; PS50835; IG_LIKE; 2.
PE 3: Inferred from homology;
KW Disulfide bond; Glycoprotein; Immunoglobulin domain; Membrane;
KW Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..27
FT /evidence="ECO:0000255"
FT CHAIN 28..868
FT /note="V-set and immunoglobulin domain-containing protein
FT 10-like"
FT /id="PRO_0000395118"
FT TOPO_DOM 28..763
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 764..784
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 785..868
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 289..381
FT /note="Ig-like C2-type 1"
FT DOMAIN 389..474
FT /note="Ig-like C2-type 2"
FT REGION 26..82
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 96..154
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 323..342
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 27..59
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 96..112
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 131..154
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 48
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 77
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 88
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 410
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 474
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 628
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 637
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 311..365
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 415..458
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
SQ SEQUENCE 868 AA; 91519 MW; 04D765B169944004 CRC64;
MGLSWALLPF LLLAFRAELL ALQPALGSQP PSASSSHSMG SSRDFVSNVS SSQHPQPPGS
EASAGIPDSN RFPQGLNSSH VPGLFRTNVS AEEQYLSPDV TSSETPPSRV SLDGLDSQDP
DKDSGLPFLV KTPASQISVQ TPDTKVPTKA SGSKLSLEHH NLEPGSKISS EIYQAASFPQ
QVGGPLAVLV GTTIRLPLTP VPSSSPPAPL VVWRRGSKVL AAGGLGSQAP LISLDPMHQA
RLRFDQIRGG LELTSARLDD AGVYTVEVIR GGVSQQIREF VVGVFEPLPQ LSVQPRAPET
EEGAAELRLS CVGWNPGSGK LSWSRDGRAL GTSDPEGAEP PRIRTERDQL LISRPVRSDH
ARYTCQVRSP FGHTEAAADV SVFYGPDAPV IRVSSDRDAS PALYVTAGSN VTLHCSAPSR
PPADIAWSLA DPTEAAVPAG PRLLLPAVGP GHGGAYACIA ANPRTGHRRR SVFNLTVADL
PPGAPQCSVE GGPVDRSLRF RCSWPGGVPA ASLQFQGLPE GVRAGPVPST LLVTVPARPE
LSGVAVTCLA RHLVATRTCT IIPEAPQEVL LQPIVEETQP GDVVVALEVT GCPPPSRASW
ARQGRPLAPG GGGRLQLSQD GRKLLINNFS LDWDLGNYSV LCSSALGAGG NQITLTGPSI
SSWRLQRAQE AAVLTWDVER GTLLTGFHIQ AWTDSSEVDR VTMSRDWVSL LILGPQERSA
IVPLPPRNPG TWAFRILPIL GSLPGTPSQS RVYQAGSDLS PGAIAGIVLG SLLGLALLAG
LLILCICCLR RYPGRASVKK QHSLTLAPVL TPPAKKIQSL TPVQTPRPLP IKTKMQSPHP
AKAQQVISPS PTLCPGGSPW TVRAATQV
