VSA1_TRYBB
ID VSA1_TRYBB Reviewed; 503 AA.
AC P06015; Q26722;
DT 13-AUG-1987, integrated into UniProtKB/Swiss-Prot.
DT 13-AUG-1987, sequence version 1.
DT 25-MAY-2022, entry version 88.
DE RecName: Full=Variant surface glycoprotein AnTaT 1.1;
DE Short=VSG;
DE AltName: Full=Expression-linked copy;
DE Short=ELC;
DE Flags: Precursor;
OS Trypanosoma brucei brucei.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma.
OX NCBI_TaxID=5702;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=6313354; DOI=10.1002/j.1460-2075.1983.tb01565.x;
RA Michiels F., Matthyssens G., Kronenberger P., Pays E., Dero B.,
RA van Assel S., Darrille M., Cravador A., Steinert M., Hamers R.;
RT "Gene activation and re-expression of a Trypanosoma brucei variant surface
RT glycoprotein.";
RL EMBO J. 2:1185-1192(1983).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-416.
RC STRAIN=EATRO 1125;
RX PubMed=2323332;
RA van der Werf A., van Assel S., Aerts D., Steinert M., Pays E.;
RT "Telomere interactions may condition the programming of antigen expression
RT in Trypanosoma brucei.";
RL EMBO J. 9:1035-1040(1990).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 391-503.
RX PubMed=7278981; DOI=10.1038/293230a0;
RA Matthyssens G., Michiels F., Hamers R., Pays E., Steinert M.;
RT "Two variant surface glycoproteins of Trypanosoma brucei have a conserved
RT C-terminus.";
RL Nature 293:230-233(1981).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 270-344.
RX PubMed=4053185; DOI=10.1016/0092-8674(85)90278-8;
RA Pays E., Houard S., Pays A., van Assel S., Dupont F., Aerts D.,
RA Huet-Duviller G., Gomes V., Richet C., Degand P., van Meirvenne N.,
RA Steinert M.;
RT "Trypanosoma brucei: the extent of conversion in antigen genes may be
RT related to the DNA coding specificity.";
RL Cell 42:821-829(1985).
CC -!- FUNCTION: VSG forms a coat on the surface of the parasite. The
CC trypanosome evades the immune response of the host by expressing a
CC series of antigenically distinct VSGs from an estimated 1000 VSG genes.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor, GPI-anchor. Note=A
CC soluble form is released from ruptured cells by the action of a PI-PLC.
CC {ECO:0000250}.
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DR EMBL; X01843; CAA25971.1; -; Genomic_DNA.
DR EMBL; X15817; CAA33809.1; -; Genomic_DNA.
DR EMBL; M12005; AAA30162.1; -; Genomic_DNA.
DR EMBL; J01213; AAA30280.1; -; mRNA.
DR PIR; S07174; VMUT1B.
DR AlphaFoldDB; P06015; -.
DR SMR; P06015; -.
DR ABCD; P06015; 17 sequenced antibodies.
DR GO; GO:0031225; C:anchored component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0042783; P:evasion of host immune response; IEA:InterPro.
DR InterPro; IPR001812; Trypano_VSG_A_N_dom.
DR InterPro; IPR019609; Variant_surf_glycoprt_trypan_C.
DR Pfam; PF00913; Trypan_glycop; 1.
DR Pfam; PF10659; Trypan_glycop_C; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; Glycoprotein; GPI-anchor; Lipoprotein;
KW Membrane; Signal; Trypanosomiasis.
FT SIGNAL 1..29
FT CHAIN 30..480
FT /note="Variant surface glycoprotein AnTaT 1.1"
FT /id="PRO_0000036409"
FT PROPEP 481..503
FT /note="Removed in mature form"
FT /evidence="ECO:0000250"
FT /id="PRO_0000036410"
FT LIPID 480
FT /note="GPI-anchor amidated aspartate"
FT /evidence="ECO:0000250"
FT CARBOHYD 113
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 419
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 432
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 45..172
FT /evidence="ECO:0000250"
FT DISULFID 154..209
FT /evidence="ECO:0000250"
FT CONFLICT 334
FT /note="A -> P (in Ref. 2; CAA33809)"
FT /evidence="ECO:0000305"
FT CONFLICT 346
FT /note="A -> V (in Ref. 2; CAA33809)"
FT /evidence="ECO:0000305"
FT CONFLICT 419
FT /note="N -> K (in Ref. 3)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 503 AA; 52814 MW; 38541B93F6DF46C6 CRC64;
MVTKERNAAL KIVMLVASAL TLHPQQALAQ TAGRPLADVV GKTLCTYSKT AKRQAANLAQ
TLQRASSAAK QSRQAQQLAA LALAKLPDYK EAAATLLIYA THKIQDAQAS IENWTGENTK
LVGQAMYSSG RIDELMLLLE GHREDGANGQ DKTCLGAAAG GNTVNEFVKT ECDTESGHNI
EADNSNIGQA ATTLSQESTD PEASGGASCK ITANLATDYD SHANELPLLG GLLTIHNAGG
FKTGQSLQTA APTNKLISAL KNKGAGVAAK LATVTSAAPT SKQELKTLLA SKGERAKLQA
ANDEYNNWKP GAKPEDFDAH IKKVFGAEDG KDSAYAIALE GISIEAPLGG GQTQNKQLYS
MQPKDLMAAL IGTIAELQTA AATKPACPGH KQTTTESDAL CSKIKDANEC NSKHFCSYNG
TETDSAKKCK YNATKASASD APVTQAQTTS RSETPAEKCT GKKKDDCKDG CKWEAETCKD
SSILLTKNFA LSVVSAALVA LLF