ID   VSA8_TRYBB              Reviewed;         115 AA.
AC   P06017;
DT   13-AUG-1987, integrated into UniProtKB/Swiss-Prot.
DT   13-AUG-1987, sequence version 1.
DT   25-MAY-2022, entry version 82.
DE   RecName: Full=Variant surface glycoprotein ANTAT 1.8;
DE            Short=VSG;
DE   Flags: Precursor; Fragment;
OS   Trypanosoma brucei brucei.
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Trypanosoma.
OX   NCBI_TaxID=5702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=7278981; DOI=10.1038/293230a0;
RA   Matthyssens G., Michiels F., Hamers R., Pays E., Steinert M.;
RT   "Two variant surface glycoproteins of Trypanosoma brucei have a conserved
RT   C-terminus.";
RL   Nature 293:230-233(1981).
CC   -!- FUNCTION: VSG forms a coat on the surface of the parasite. The
CC       trypanosome evades the immune response of the host by expressing a
CC       series of antigenically distinct VSGs from an estimated 1000 VSG genes.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor, GPI-anchor. Note=A
CC       soluble form is released from ruptured cells by the action of a PI-PLC.
CC       {ECO:0000250}.
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DR   EMBL; J01227; AAA30292.1; -; mRNA.
DR   PIR; S07326; S07326.
DR   AlphaFoldDB; P06017; -.
DR   SMR; P06017; -.
DR   GO; GO:0031225; C:anchored component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR019609; Variant_surf_glycoprt_trypan_C.
DR   Pfam; PF10659; Trypan_glycop_C; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Glycoprotein; GPI-anchor; Lipoprotein; Membrane;
KW   Trypanosomiasis.
FT   CHAIN           <1..92
FT                   /note="Variant surface glycoprotein ANTAT 1.8"
FT                   /id="PRO_0000036413"
FT   PROPEP          93..115
FT                   /note="Removed in mature form"
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000036414"
FT   LIPID           92
FT                   /note="GPI-anchor amidated aspartate"
FT                   /evidence="ECO:0000250"
FT   CARBOHYD        42
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   NON_TER         1
SQ   SEQUENCE   115 AA;  12530 MW;  12761F33D1305C7E CRC64;
     DQKGKSPESE CNKISEEPKC NEDKICSWHK EVKAGEKHCK FNSTKAKEKG VAVTQTQTAG
     GTEATTDKCK GKLEDTCKKE SNCKWEGETC KDSSILVNKQ LALSVVSAAF AALLF