ID   VSAC_TRYBB              Reviewed;         482 AA.
AC   P06016;
DT   13-AUG-1987, integrated into UniProtKB/Swiss-Prot.
DT   13-AUG-1987, sequence version 1.
DT   25-MAY-2022, entry version 81.
DE   RecName: Full=Variant surface glycoprotein ANTAT 1.1C;
DE            Short=VSG;
DE   Flags: Precursor; Fragment;
OS   Trypanosoma brucei brucei.
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Trypanosoma.
OX   NCBI_TaxID=5702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=6197182; DOI=10.1016/0092-8674(83)90105-8;
RA   Pays E., Delauw M.-F., van Assel S., Laurent M., Vervoort T.,
RA   van Meirvenne N., Steinert M.;
RT   "Modifications of a Trypanosoma b. brucei antigen gene repertoire by
RT   different DNA recombinational mechanisms.";
RL   Cell 35:721-731(1983).
CC   -!- FUNCTION: VSG forms a coat on the surface of the parasite. The
CC       trypanosome evades the immune response of the host by expressing a
CC       series of antigenically distinct VSGs from an estimated 1000 VSG genes.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor, GPI-anchor. Note=A
CC       soluble form is released from ruptured cells by the action of a PI-PLC.
CC       {ECO:0000250}.
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DR   EMBL; K01656; AAA30285.1; -; Genomic_DNA.
DR   AlphaFoldDB; P06016; -.
DR   SMR; P06016; -.
DR   GO; GO:0031225; C:anchored component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0042783; P:evasion of host immune response; IEA:InterPro.
DR   InterPro; IPR001812; Trypano_VSG_A_N_dom.
DR   InterPro; IPR019609; Variant_surf_glycoprt_trypan_C.
DR   Pfam; PF00913; Trypan_glycop; 1.
DR   Pfam; PF10659; Trypan_glycop_C; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Disulfide bond; Glycoprotein; GPI-anchor; Lipoprotein;
KW   Membrane; Signal; Trypanosomiasis.
FT   SIGNAL          <1..8
FT   CHAIN           9..459
FT                   /note="Variant surface glycoprotein ANTAT 1.1C"
FT                   /id="PRO_0000036411"
FT   PROPEP          460..482
FT                   /note="Removed in mature form"
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000036412"
FT   LIPID           459
FT                   /note="GPI-anchor amidated aspartate"
FT                   /evidence="ECO:0000250"
FT   CARBOHYD        92
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        398
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        411
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        24..151
FT                   /evidence="ECO:0000250"
FT   DISULFID        133..188
FT                   /evidence="ECO:0000250"
FT   NON_TER         1
SQ   SEQUENCE   482 AA;  50807 MW;  87CA7B8841589BDD CRC64;
     LHPQQALAQT AGRPLADVVG KTLCTYSKTA KRQAANLAQT LQRASSAAKQ SRQAQQLAAL
     ALAKLPDYKE AAATLLIYAT HKIQDAQASI ENWTGENTKL VGQAMYSSGR IDELMLLLEG
     HREDGANGQD KTCLGAAAGG NTVNEFVKTE CDTESGHNIE ADNSNIGQAA TTLSQESTDP
     EASGGASCKI TANLATDYDS HANELPLLGG LLTIHNAGGF KTGQSLQTAA PTNKLISALK
     NKGAGVAAKL ATVTSAAPTS KQELKTLLAS KGERAKLQAA NDEYNNWKPG AKPEDFDAHI
     KKVFGAEDGK DSAYALALEG ISIEVPQKPG TTESKQLYSM QPKDLMAALI GTIAEIQKAA
     ATKAPCPKHK LTSAESDALC SKIKDANECN SKPFCSYNST ETDTAKKCQF NETKADKSGV
     SLPKTGPTGT EATTDKCKDK TKDECKSPNC KWEGETCKDS SILVTKKFAL SLVSAAFASL
     LF