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VSE2_TRYBR
ID   VSE2_TRYBR              Reviewed;          55 AA.
AC   P26335;
DT   01-MAY-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1992, sequence version 1.
DT   25-MAY-2022, entry version 59.
DE   RecName: Full=Variant surface glycoprotein ETAT 1.2;
DE   Flags: Precursor; Fragment;
OS   Trypanosoma brucei rhodesiense.
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Trypanosoma.
OX   NCBI_TaxID=31286;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=2528066; DOI=10.1016/0166-6851(89)90189-8;
RA   de Greef C., Imberechts H., Matthyssens G., van Meirvenne N., Hamers R.;
RT   "A gene expressed only in serum-resistant variants of Trypanosoma brucei
RT   rhodesiense.";
RL   Mol. Biochem. Parasitol. 36:169-176(1989).
CC   -!- FUNCTION: VSG forms a coat on the surface of the parasite. The
CC       trypanosome evades the immune response of the host by expressing a
CC       series of antigenically distinct VSGs from an estimated 1000 VSG genes.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor, GPI-anchor. Note=A
CC       soluble form is released from ruptured cells by the action of a PI-PLC.
CC       {ECO:0000250}.
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DR   EMBL; J04651; AAA30287.1; -; mRNA.
DR   PIR; A45530; A45530.
DR   AlphaFoldDB; P26335; -.
DR   GO; GO:0031225; C:anchored component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR027446; VSG_C_dom_sf.
DR   SUPFAM; SSF118251; SSF118251; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Glycoprotein; GPI-anchor; Lipoprotein; Membrane;
KW   Trypanosomiasis.
FT   CHAIN           <1..38
FT                   /note="Variant surface glycoprotein ETAT 1.2"
FT                   /id="PRO_0000036445"
FT   PROPEP          39..55
FT                   /note="Removed in mature form"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000036446"
FT   LIPID           38
FT                   /note="GPI-anchor amidated asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        34
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   NON_TER         1
SQ   SEQUENCE   55 AA;  6077 MW;  D0ADC851BA8E0703 CRC64;
     KNTGRRPNYR ECEMRDGECN AKVAKTAEPD SKTNTTGNNS FAIKTSTLLL AVLLF
 
 
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