VSE2_TRYBR
ID VSE2_TRYBR Reviewed; 55 AA.
AC P26335;
DT 01-MAY-1992, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1992, sequence version 1.
DT 25-MAY-2022, entry version 59.
DE RecName: Full=Variant surface glycoprotein ETAT 1.2;
DE Flags: Precursor; Fragment;
OS Trypanosoma brucei rhodesiense.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma.
OX NCBI_TaxID=31286;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=2528066; DOI=10.1016/0166-6851(89)90189-8;
RA de Greef C., Imberechts H., Matthyssens G., van Meirvenne N., Hamers R.;
RT "A gene expressed only in serum-resistant variants of Trypanosoma brucei
RT rhodesiense.";
RL Mol. Biochem. Parasitol. 36:169-176(1989).
CC -!- FUNCTION: VSG forms a coat on the surface of the parasite. The
CC trypanosome evades the immune response of the host by expressing a
CC series of antigenically distinct VSGs from an estimated 1000 VSG genes.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor, GPI-anchor. Note=A
CC soluble form is released from ruptured cells by the action of a PI-PLC.
CC {ECO:0000250}.
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DR EMBL; J04651; AAA30287.1; -; mRNA.
DR PIR; A45530; A45530.
DR AlphaFoldDB; P26335; -.
DR GO; GO:0031225; C:anchored component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR027446; VSG_C_dom_sf.
DR SUPFAM; SSF118251; SSF118251; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Glycoprotein; GPI-anchor; Lipoprotein; Membrane;
KW Trypanosomiasis.
FT CHAIN <1..38
FT /note="Variant surface glycoprotein ETAT 1.2"
FT /id="PRO_0000036445"
FT PROPEP 39..55
FT /note="Removed in mature form"
FT /evidence="ECO:0000255"
FT /id="PRO_0000036446"
FT LIPID 38
FT /note="GPI-anchor amidated asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 34
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT NON_TER 1
SQ SEQUENCE 55 AA; 6077 MW; D0ADC851BA8E0703 CRC64;
KNTGRRPNYR ECEMRDGECN AKVAKTAEPD SKTNTTGNNS FAIKTSTLLL AVLLF