ID   VSG2_TRYEQ              Reviewed;         457 AA.
AC   P20950;
DT   01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1991, sequence version 1.
DT   25-MAY-2022, entry version 81.
DE   RecName: Full=Variant surface glycoprotein 20;
DE            Short=VSG-20;
DE   Flags: Precursor;
OS   Trypanosoma equiperdum.
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Trypanosoma.
OX   NCBI_TaxID=5694;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=BoTat 20;
RX   PubMed=2792762; DOI=10.1101/gad.3.8.1247;
RA   Thon G., Baltz T., Eisen H.;
RT   "Antigenic diversity by the recombination of pseudogenes.";
RL   Genes Dev. 3:1247-1254(1989).
CC   -!- FUNCTION: VSG forms a coat on the surface of the parasite. The
CC       trypanosome evades the immune response of the host by expressing a
CC       series of antigenically distinct VSGs from an estimated 1000 VSG genes.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor, GPI-anchor. Note=A
CC       soluble form is released from ruptured cells by the action of a PI-PLC.
CC       {ECO:0000250}.
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DR   EMBL; X16723; CAA34704.1; -; mRNA.
DR   AlphaFoldDB; P20950; -.
DR   SMR; P20950; -.
DR   GO; GO:0031225; C:anchored component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR027446; VSG_C_dom_sf.
DR   SUPFAM; SSF118251; SSF118251; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Glycoprotein; GPI-anchor; Lipoprotein; Membrane; Signal;
KW   Trypanosomiasis.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   CHAIN           21..440
FT                   /note="Variant surface glycoprotein 20"
FT                   /id="PRO_0000036457"
FT   PROPEP          441..457
FT                   /note="Removed in mature form"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000036458"
FT   REGION          385..406
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   LIPID           440
FT                   /note="GPI-anchor amidated serine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        436
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   457 AA;  49416 MW;  EE3A5BF2B17F3F8D CRC64;
     MFTQAVIALI GLVSIRTGKT EDVTPCTTNC GCWARLEKQI TVYRGDYSAA EENLKENKKN
     FGKIIAATVL GSEKLKATVA PVLLSAAQII HECEEALTTA RPAILDAEKK VAELRALYDV
     QQKLKEGNGE LQLHIQDDTN INTAKEVPKA NLGNINKKGC ADDLNTPDAA TIDKTNIETE
     GPTPKVITHV HVEARCQRDG TPTNGCHDGQ LGQNGKLEFS LTYDSKDTND LATWLADTAT
     KKQISATEVD FIGNLNTEAN TAIKGLKSSN PAPACSKKIR DYKTIADNSK FNLMVTKALI
     GKTDAEAGQE SKEPELAAAI TKYYGTEGTK FEDQLWKAIE RTPAYLGDQK KEQTTKIEKL
     ETLTEVGEAT ARGLVKQLAA GAQARQTASG DDQSAENQCG GKKEDECKDG CELVEGVCKP
     VKQGEGENKE KTGTTNTTGS NSFVIKKAPL WLAFLLF