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VSG7_TRYBR
ID   VSG7_TRYBR              Reviewed;         467 AA.
AC   P02898;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   21-JUL-1986, sequence version 1.
DT   25-MAY-2022, entry version 74.
DE   RecName: Full=Variant surface glycoprotein 7;
DE            Short=VSG 7;
DE   AltName: Full=Metacyclic variable antigen;
DE   Flags: Precursor; Fragments;
OS   Trypanosoma brucei rhodesiense.
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Trypanosoma.
OX   NCBI_TaxID=31286;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=6593722; DOI=10.1073/pnas.81.21.6642;
RA   Lenardo M.J., Rice-Ficht A.C., Kelly G., Esser K.M., Donelson J.E.;
RT   "Characterization of the genes specifying two metacyclic variable antigen
RT   types in Trypanosoma brucei rhodesiense.";
RL   Proc. Natl. Acad. Sci. U.S.A. 81:6642-6646(1984).
CC   -!- FUNCTION: VSG forms a coat on the surface of the parasite. The
CC       trypanosome evades the immune response of the host by expressing a
CC       series of antigenically distinct VSGs from an estimated 1000 VSG genes.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor, GPI-anchor. Note=A
CC       soluble form is released from ruptured cells by the action of a PI-PLC.
CC       {ECO:0000250}.
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DR   PIR; A03393; VMUT7R.
DR   AlphaFoldDB; P02898; -.
DR   SMR; P02898; -.
DR   GO; GO:0031225; C:anchored component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR019609; Variant_surf_glycoprt_trypan_C.
DR   Pfam; PF10659; Trypan_glycop_C; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Glycoprotein; GPI-anchor; Lipoprotein; Membrane;
KW   Trypanosomiasis.
FT   CHAIN           <1..444
FT                   /note="Variant surface glycoprotein 7"
FT                   /id="PRO_0000036443"
FT   PROPEP          445..467
FT                   /note="Removed in mature form"
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000036444"
FT   REGION          77..133
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          382..407
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        77..91
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        386..407
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   LIPID           444
FT                   /note="GPI-anchor amidated aspartate"
FT                   /evidence="ECO:0000250"
FT   CARBOHYD        108
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        252
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        416
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   NON_CONS        87..88
FT                   /evidence="ECO:0000305"
FT   NON_TER         1
SQ   SEQUENCE   467 AA;  49963 MW;  3A4805AFFBECA686 CRC64;
     SEPTMSTRVQ QATSCVLLII GCTNYAASKQ QTENNAVCDT PCKCLGRLAV QKAYLEGALE
     HARQSIKAFA SSSRQHTIAA GATNTKLSGH HPNQGRRGRR RSSSARPNNS KGNSPSKRAG
     GAVRGETPAS GRLKAAKLLK SSNYETATFT PTEMTIQNRR ACEQVDESKE YRFDELNFDK
     EQGIPTPALT LEISMGCQKN PGDTGGACDG TNADDGVVTK LTFTTAAPVA ETSPLVAGAY
     KKTSKASLSI SNRTEEGRVA NSKAAHEAAK RLMAIKQPSD LSTYTDDSSF ALLVGQLAMK
     PPLGAELTPA LRDQVNKFIT DNYGANEGDF RSKFLAKTEQ AAVFYLDGKS KKTKKISELE
     SKSELVTASG YAFFKGIHTE QAEKVENPRS QGNPETAENK KEGGNTAKPF CSTIQNQTEC
     EGVKGTPPTG KAKVCGWIEG KCQDSSFLLS KQFALSVVSA AFAALLF
 
 
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