VSG7_TRYBR
ID VSG7_TRYBR Reviewed; 467 AA.
AC P02898;
DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT 21-JUL-1986, sequence version 1.
DT 25-MAY-2022, entry version 74.
DE RecName: Full=Variant surface glycoprotein 7;
DE Short=VSG 7;
DE AltName: Full=Metacyclic variable antigen;
DE Flags: Precursor; Fragments;
OS Trypanosoma brucei rhodesiense.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma.
OX NCBI_TaxID=31286;
RN [1]
RP NUCLEOTIDE SEQUENCE.
RX PubMed=6593722; DOI=10.1073/pnas.81.21.6642;
RA Lenardo M.J., Rice-Ficht A.C., Kelly G., Esser K.M., Donelson J.E.;
RT "Characterization of the genes specifying two metacyclic variable antigen
RT types in Trypanosoma brucei rhodesiense.";
RL Proc. Natl. Acad. Sci. U.S.A. 81:6642-6646(1984).
CC -!- FUNCTION: VSG forms a coat on the surface of the parasite. The
CC trypanosome evades the immune response of the host by expressing a
CC series of antigenically distinct VSGs from an estimated 1000 VSG genes.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor, GPI-anchor. Note=A
CC soluble form is released from ruptured cells by the action of a PI-PLC.
CC {ECO:0000250}.
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DR PIR; A03393; VMUT7R.
DR AlphaFoldDB; P02898; -.
DR SMR; P02898; -.
DR GO; GO:0031225; C:anchored component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR019609; Variant_surf_glycoprt_trypan_C.
DR Pfam; PF10659; Trypan_glycop_C; 1.
PE 3: Inferred from homology;
KW Cell membrane; Glycoprotein; GPI-anchor; Lipoprotein; Membrane;
KW Trypanosomiasis.
FT CHAIN <1..444
FT /note="Variant surface glycoprotein 7"
FT /id="PRO_0000036443"
FT PROPEP 445..467
FT /note="Removed in mature form"
FT /evidence="ECO:0000250"
FT /id="PRO_0000036444"
FT REGION 77..133
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 382..407
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 77..91
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 386..407
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT LIPID 444
FT /note="GPI-anchor amidated aspartate"
FT /evidence="ECO:0000250"
FT CARBOHYD 108
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 252
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 416
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT NON_CONS 87..88
FT /evidence="ECO:0000305"
FT NON_TER 1
SQ SEQUENCE 467 AA; 49963 MW; 3A4805AFFBECA686 CRC64;
SEPTMSTRVQ QATSCVLLII GCTNYAASKQ QTENNAVCDT PCKCLGRLAV QKAYLEGALE
HARQSIKAFA SSSRQHTIAA GATNTKLSGH HPNQGRRGRR RSSSARPNNS KGNSPSKRAG
GAVRGETPAS GRLKAAKLLK SSNYETATFT PTEMTIQNRR ACEQVDESKE YRFDELNFDK
EQGIPTPALT LEISMGCQKN PGDTGGACDG TNADDGVVTK LTFTTAAPVA ETSPLVAGAY
KKTSKASLSI SNRTEEGRVA NSKAAHEAAK RLMAIKQPSD LSTYTDDSSF ALLVGQLAMK
PPLGAELTPA LRDQVNKFIT DNYGANEGDF RSKFLAKTEQ AAVFYLDGKS KKTKKISELE
SKSELVTASG YAFFKGIHTE QAEKVENPRS QGNPETAENK KEGGNTAKPF CSTIQNQTEC
EGVKGTPPTG KAKVCGWIEG KCQDSSFLLS KQFALSVVSA AFAALLF