ID   VSI0_TRYBB              Reviewed;         320 AA.
AC   P06013;
DT   13-AUG-1987, integrated into UniProtKB/Swiss-Prot.
DT   13-AUG-1987, sequence version 1.
DT   25-MAY-2022, entry version 71.
DE   RecName: Full=Variant surface glycoprotein ILTAT 1.2;
DE            Short=VSG;
DE   Flags: Fragment;
OS   Trypanosoma brucei brucei.
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Trypanosoma.
OX   NCBI_TaxID=5702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Rice-Ficht A.C., Chen K.K., Donelson J.E.;
RT   "Sequence homologies near the C-termini of the variable surface
RT   glycoproteins of Trypanosoma brucei.";
RL   Nature 294:53-57(1981).
CC   -!- FUNCTION: VSG forms a coat on the surface of the parasite. The
CC       trypanosome evades the immune response of the host by expressing a
CC       series of antigenically distinct VSGs from an estimated 1000 VSG genes.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor, GPI-anchor. Note=A
CC       soluble form is released from ruptured cells by the action of a PI-PLC.
CC       {ECO:0000250}.
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DR   EMBL; J01220; AAA30286.1; -; mRNA.
DR   PIR; S09639; S09639.
DR   AlphaFoldDB; P06013; -.
DR   SMR; P06013; -.
DR   GO; GO:0031225; C:anchored component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0042783; P:evasion of host immune response; IEA:InterPro.
DR   InterPro; IPR001812; Trypano_VSG_A_N_dom.
DR   InterPro; IPR019609; Variant_surf_glycoprt_trypan_C.
DR   Pfam; PF00913; Trypan_glycop; 1.
DR   Pfam; PF10659; Trypan_glycop_C; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Glycoprotein; GPI-anchor; Lipoprotein; Membrane;
KW   Trypanosomiasis.
FT   CHAIN           <1..>320
FT                   /note="Variant surface glycoprotein ILTAT 1.2"
FT                   /id="PRO_0000221676"
FT   REGION          297..320
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        301..320
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        146
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        282
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        295
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   NON_TER         1
FT   NON_TER         320
SQ   SEQUENCE   320 AA;  33871 MW;  D6F18DA8208063C8 CRC64;
     ASGKGCLLGH DNSGYYQAKK LQGEDNTECD LEPHELKLSP LEIEVTDADG FTNGLAPGVA
     DSHQTQGTKE CGLLTAHGNN GLAKSGALDQ NPKLLMGVFT VASSNSALTV ADLTKAATSA
     IANTGLGQAH AAVKAIQDAN PAANDNTSTS EDTAELQTAI MHLELQAATA GSRNMKEETK
     KIFTNKVQDT ITKVLHNVYS HQITVPFVNN GKDTPLRSIP NTGELMEILA FYEQKVADNT
     AKTQKELTEA QQAMKTDRSG DGGCTQITEP TACNSKPFCS YNESTTDDDK KCKYNATKAT
     ENGVPVAQTQ TGGSETTTEK