VSI10_HUMAN
ID VSI10_HUMAN Reviewed; 540 AA.
AC Q8N0Z9; Q9NWQ7;
DT 22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 156.
DE RecName: Full=V-set and immunoglobulin domain-containing protein 10;
DE Flags: Precursor;
GN Name=VSIG10;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND VARIANT TYR-435.
RC TISSUE=Ileal mucosa;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8N0Z9-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8N0Z9-2; Sequence=VSP_034915;
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DR EMBL; AK000681; BAA91322.1; -; mRNA.
DR EMBL; BC028698; AAH28698.2; -; mRNA.
DR EMBL; BC034471; AAH34471.1; -; mRNA.
DR CCDS; CCDS44992.1; -. [Q8N0Z9-1]
DR RefSeq; NP_061959.2; NM_019086.5. [Q8N0Z9-1]
DR AlphaFoldDB; Q8N0Z9; -.
DR SMR; Q8N0Z9; -.
DR BioGRID; 120079; 2.
DR IntAct; Q8N0Z9; 1.
DR STRING; 9606.ENSP00000352172; -.
DR GlyGen; Q8N0Z9; 9 sites.
DR iPTMnet; Q8N0Z9; -.
DR PhosphoSitePlus; Q8N0Z9; -.
DR BioMuta; VSIG10; -.
DR DMDM; 74759757; -.
DR EPD; Q8N0Z9; -.
DR jPOST; Q8N0Z9; -.
DR MassIVE; Q8N0Z9; -.
DR MaxQB; Q8N0Z9; -.
DR PaxDb; Q8N0Z9; -.
DR PeptideAtlas; Q8N0Z9; -.
DR PRIDE; Q8N0Z9; -.
DR ProteomicsDB; 71496; -. [Q8N0Z9-1]
DR ProteomicsDB; 71497; -. [Q8N0Z9-2]
DR TopDownProteomics; Q8N0Z9-2; -. [Q8N0Z9-2]
DR Antibodypedia; 3044; 34 antibodies from 15 providers.
DR DNASU; 54621; -.
DR Ensembl; ENST00000359236.10; ENSP00000352172.5; ENSG00000176834.14. [Q8N0Z9-1]
DR GeneID; 54621; -.
DR KEGG; hsa:54621; -.
DR MANE-Select; ENST00000359236.10; ENSP00000352172.5; NM_019086.6; NP_061959.2.
DR UCSC; uc001tws.4; human. [Q8N0Z9-1]
DR CTD; 54621; -.
DR GeneCards; VSIG10; -.
DR HGNC; HGNC:26078; VSIG10.
DR HPA; ENSG00000176834; Low tissue specificity.
DR neXtProt; NX_Q8N0Z9; -.
DR OpenTargets; ENSG00000176834; -.
DR PharmGKB; PA165513585; -.
DR VEuPathDB; HostDB:ENSG00000176834; -.
DR eggNOG; ENOG502R53I; Eukaryota.
DR GeneTree; ENSGT00940000159876; -.
DR HOGENOM; CLU_037960_1_0_1; -.
DR InParanoid; Q8N0Z9; -.
DR OMA; PMVEWWF; -.
DR OrthoDB; 1221933at2759; -.
DR PhylomeDB; Q8N0Z9; -.
DR TreeFam; TF334050; -.
DR PathwayCommons; Q8N0Z9; -.
DR BioGRID-ORCS; 54621; 16 hits in 1073 CRISPR screens.
DR ChiTaRS; VSIG10; human.
DR GenomeRNAi; 54621; -.
DR Pharos; Q8N0Z9; Tdark.
DR PRO; PR:Q8N0Z9; -.
DR Proteomes; UP000005640; Chromosome 12.
DR RNAct; Q8N0Z9; protein.
DR Bgee; ENSG00000176834; Expressed in buccal mucosa cell and 165 other tissues.
DR ExpressionAtlas; Q8N0Z9; baseline and differential.
DR Genevisible; Q8N0Z9; HS.
DR GO; GO:0005911; C:cell-cell junction; IBA:GO_Central.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0050839; F:cell adhesion molecule binding; IBA:GO_Central.
DR GO; GO:0098609; P:cell-cell adhesion; IBA:GO_Central.
DR Gene3D; 2.60.40.10; -; 3.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR013106; Ig_V-set.
DR Pfam; PF07686; V-set; 1.
DR SMART; SM00409; IG; 3.
DR SMART; SM00408; IGc2; 3.
DR SMART; SM00406; IGv; 2.
DR SUPFAM; SSF48726; SSF48726; 4.
DR PROSITE; PS50835; IG_LIKE; 4.
PE 2: Evidence at transcript level;
KW Alternative splicing; Disulfide bond; Glycoprotein; Immunoglobulin domain;
KW Membrane; Reference proteome; Repeat; Signal; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..30
FT /evidence="ECO:0000255"
FT CHAIN 31..540
FT /note="V-set and immunoglobulin domain-containing protein
FT 10"
FT /id="PRO_0000345115"
FT TOPO_DOM 31..413
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 414..434
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 435..540
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 31..119
FT /note="Ig-like C2-type 1"
FT DOMAIN 123..215
FT /note="Ig-like C2-type 2"
FT DOMAIN 223..309
FT /note="Ig-like C2-type 3"
FT DOMAIN 311..404
FT /note="Ig-like C2-type 4"
FT REGION 461..500
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 513..540
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 461..479
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 480..500
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 39
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 46
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 70
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 108
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 138
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 171
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 180
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 198
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 326
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 44..103
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 153..201
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 245..290
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 331..388
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT VAR_SEQ 463..464
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_034915"
FT VARIANT 333
FT /note="V -> M (in dbSNP:rs9668527)"
FT /id="VAR_045692"
FT VARIANT 435
FT /note="H -> Y (in dbSNP:rs7307331)"
FT /evidence="ECO:0000269|PubMed:14702039"
FT /id="VAR_045693"
FT CONFLICT 25
FT /note="A -> T (in Ref. 1; BAA91322)"
FT /evidence="ECO:0000305"
FT CONFLICT 34..37
FT /note="GEVH -> WRSY (in Ref. 1; BAA91322)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 540 AA; 59217 MW; A1265F81786DDCDD CRC64;
MAAGGSAPEP RVLVCLGALL AGWVAVGLEA VVIGEVHENV TLHCGNISGL RGQVTWYRNN
SEPVFLLSSN SSLRPAEPRF SLVDATSLHI ESLSLGDEGI YTCQEILNVT QWFQVWLQVA
SGPYQIEVHI VATGTLPNGT LYAARGSQVD FSCNSSSRPP PVVEWWFQAL NSSSESFGHN
LTVNFFSLLL ISPNLQGNYT CLALNQLSKR HRKVTTELLV YYPPPSAPQC WAQMASGSFM
LQLTCRWDGG YPDPDFLWIE EPGGVIVGKS KLGVEMLSES QLSDGKKFKC VTSHIVGPES
GASCMVQIRG PSLLSEPMKT CFTGGNVTLT CQVSGAYPPA KILWLRNLTQ PEVIIQPSSR
HLITQDGQNS TLTIHNCSQD LDEGYYICRA DSPVGVREME IWLSVKEPLN IGGIVGTIVS
LLLLGLAIIS GLLLHYSPVF CWKVGNTSRG QNMDDVMVLV DSEEEEEEEE EEEEDAAVGE
QEGAREREEL PKEIPKQDHI HRVTALVNGN IEQMGNGFQD LQDDSSEEQS DIVQEEDRPV
