ID   VSIB_TRYBB              Reviewed;         471 AA.
AC   P07208;
DT   01-APR-1988, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1988, sequence version 1.
DT   25-MAY-2022, entry version 83.
DE   RecName: Full=Variant surface glycoprotein ILTAT 1.1BC;
DE            Short=VSG;
DE   Flags: Precursor;
OS   Trypanosoma brucei brucei.
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Trypanosoma.
OX   NCBI_TaxID=5702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=6927851; DOI=10.1038/298676a0;
RA   Rice-Ficht A.C., Chen K.K., Donelson J.E.;
RT   "Point mutations during generation of expression-linked extra copy of
RT   trypanosome surface glycoprotein gene.";
RL   Nature 298:676-679(1982).
CC   -!- FUNCTION: VSG forms a coat on the surface of the parasite. The
CC       trypanosome evades the immune response of the host by expressing a
CC       series of antigenically distinct VSGs from an estimated 1000 VSG genes.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor, GPI-anchor. Note=A
CC       soluble form is released from ruptured cells by the action of a PI-PLC.
CC       {ECO:0000250}.
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DR   EMBL; V01384; CAA24674.1; -; Genomic_DNA.
DR   PIR; S07329; S07329.
DR   AlphaFoldDB; P07208; -.
DR   SMR; P07208; -.
DR   GO; GO:0031225; C:anchored component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR027446; VSG_C_dom_sf.
DR   SUPFAM; SSF118251; SSF118251; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Disulfide bond; Glycoprotein; GPI-anchor; Lipoprotein;
KW   Membrane; Signal; Trypanosomiasis.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   CHAIN           22..454
FT                   /note="Variant surface glycoprotein ILTAT 1.1BC"
FT                   /id="PRO_0000036415"
FT   PROPEP          455..471
FT                   /note="Removed in mature form"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000036416"
FT   REGION          158..183
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          204..232
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          432..454
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        167..183
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        206..232
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        434..454
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   LIPID           454
FT                   /note="GPI-anchor amidated serine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        130
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        220
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        260
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        450
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        397..410
FT                   /evidence="ECO:0000250"
FT   DISULFID        406..421
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   471 AA;  50521 MW;  3F31B229E295B6D1 CRC64;
     MVKAIASLML LHIWAIEEIK AERQAPSVSR TECTTPCRCA QRLEKLKKHC QMRVQTAVRK
     QKENGKLAQK LLIGTITSTA GGGEQTSTTS FLLSNSSPTR RETLETNQAE IMSQLEHIIA
     MEAQYYAILN VSATSTDTTL DGDGTQYNTG SITSGGFTVS KTTECNTESP EDTKEPDQTT
     LSKKQGLKDL KLALRVKVAC KNGGGACSAA SSSDKIHITN ETDSKNKGTT ASTMNSQNTA
     VAFATDLQIV NWKSDHIDSN ITALANALTA LDSIPDLTDP AAYTADAAFK QLVATVTLNK
     PPTTELTGEV LDAVNRACAD NYGTSASELT TKIWDPLNEQ AASYYSDKTI KTDQLKLLTS
     NQQLTTALGV ALAKAINVKE ASKKECNLHG HETDATCEAK GVGDNCKPPC KEVEEGGKKK
     CKLDKEEAKR VAEQAATNQE TEGKDGKTTN TTGSNSFLIN KAPVLLAFLL L