ID   VSIG1_BOVIN             Reviewed;         382 AA.
AC   Q29RR6;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   04-APR-2006, sequence version 1.
DT   25-MAY-2022, entry version 80.
DE   RecName: Full=V-set and immunoglobulin domain-containing protein 1;
DE   Flags: Precursor;
GN   Name=VSIG1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Testis;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC       membrane protein {ECO:0000305}.
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DR   EMBL; BC114057; AAI14058.1; -; mRNA.
DR   RefSeq; NP_001039395.1; NM_001045930.2.
DR   AlphaFoldDB; Q29RR6; -.
DR   SMR; Q29RR6; -.
DR   STRING; 9913.ENSBTAP00000010335; -.
DR   PaxDb; Q29RR6; -.
DR   GeneID; 505937; -.
DR   KEGG; bta:505937; -.
DR   CTD; 340547; -.
DR   eggNOG; ENOG502QU0R; Eukaryota.
DR   InParanoid; Q29RR6; -.
DR   OrthoDB; 841952at2759; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0016323; C:basolateral plasma membrane; IBA:GO_Central.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0003382; P:epithelial cell morphogenesis; IEA:InterPro.
DR   GO; GO:0030277; P:maintenance of gastrointestinal epithelium; IBA:GO_Central.
DR   Gene3D; 2.60.40.10; -; 2.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR003598; Ig_sub2.
DR   InterPro; IPR013106; Ig_V-set.
DR   InterPro; IPR029861; VSIG1.
DR   PANTHER; PTHR44974; PTHR44974; 1.
DR   Pfam; PF07686; V-set; 1.
DR   SMART; SM00409; IG; 2.
DR   SMART; SM00408; IGc2; 2.
DR   SMART; SM00406; IGv; 1.
DR   SUPFAM; SSF48726; SSF48726; 2.
DR   PROSITE; PS50835; IG_LIKE; 2.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Glycoprotein; Immunoglobulin domain; Membrane;
KW   Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   CHAIN           22..382
FT                   /note="V-set and immunoglobulin domain-containing protein
FT                   1"
FT                   /id="PRO_0000313572"
FT   TOPO_DOM        22..234
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        235..255
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        256..382
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          22..133
FT                   /note="Ig-like V-type"
FT   DOMAIN          140..227
FT                   /note="Ig-like C2-type"
FT   REGION          266..382
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        321..341
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        32
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        200
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        219
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        43..116
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT   DISULFID        161..211
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
SQ   SEQUENCE   382 AA;  41657 MW;  34590C2D574C66E7 CRC64;
     MGLTFWKVFL ILNCLAGQVN GVQVTIPDSF VNVTVGSDVT LICTYATTVA SLNKLSIQWT
     FFHKEASQPV SIYYSEGGQA TAIGKFKDRI VGSNTSGNAS ITISHMQPED SGIYICDVNN
     PTDFFGKNQG TISVSVLVKP SKPFCSIQGI AETGHPISLT CLSVLGTPSP VYYWYKLEGR
     NIVPVKENFN PATGILFIGN LTTFEQGYYQ CTAINILGNS SCEIDLTTPY PGIGIIVGAF
     VGTLIGVIII ISVVWFVRRK VKAKGKERKR NSKTTTELEP MTKINQRTEG ETMPREDAIQ
     LEATLPSSTH ETEPNATLGP DHEPIPEPEP ALQPTVEPPS GPELVPMSEL EIQLEPEPAP
     QQEPEPLIVD EPFCDEEKVI KP