VSIG2_HUMAN
ID VSIG2_HUMAN Reviewed; 327 AA.
AC Q96IQ7; O95791; Q9NX42;
DT 21-JUN-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 154.
DE RecName: Full=V-set and immunoglobulin domain-containing protein 2;
DE AltName: Full=Cortical thymocyte-like protein;
DE Short=CT-like protein;
DE Flags: Precursor;
GN Name=VSIG2; Synonyms=CTH, CTXL; ORFNames=UNQ2770/PRO7154;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND TISSUE SPECIFICITY.
RX PubMed=9862345;
RX DOI=10.1002/(sici)1521-4141(199812)28:12<4094::aid-immu4094>3.0.co;2-2;
RA Chretien I., Marcuz A., Courtet M., Katevuo K., Vainio O., Heath J.K.,
RA White S.J., Du Pasquier L.;
RT "CTX, a Xenopus thymocyte receptor, defines a molecular family conserved
RT throughout vertebrates.";
RL Eur. J. Immunol. 28:4094-4104(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT identify novel human secreted and transmembrane proteins: a bioinformatics
RT assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Colon;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP PROTEIN SEQUENCE OF 24-38.
RX PubMed=15340161; DOI=10.1110/ps.04682504;
RA Zhang Z., Henzel W.J.;
RT "Signal peptide prediction based on analysis of experimentally verified
RT cleavage sites.";
RL Protein Sci. 13:2819-2824(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q96IQ7-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q96IQ7-2; Sequence=VSP_014119;
CC -!- TISSUE SPECIFICITY: Highly expressed in stomach, colon, prostate,
CC trachea and thyroid glands and weakly in bladder and lung.
CC {ECO:0000269|PubMed:9862345}.
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DR EMBL; AF061022; AAD17522.1; -; Genomic_DNA.
DR EMBL; AY358897; AAQ89256.1; -; mRNA.
DR EMBL; AK000460; BAA91179.1; -; mRNA.
DR EMBL; BC007313; AAH07313.1; -; mRNA.
DR CCDS; CCDS8452.1; -. [Q96IQ7-1]
DR CCDS; CCDS86258.1; -. [Q96IQ7-2]
DR RefSeq; NP_001316849.1; NM_001329920.1. [Q96IQ7-2]
DR RefSeq; NP_055127.2; NM_014312.4. [Q96IQ7-1]
DR AlphaFoldDB; Q96IQ7; -.
DR SMR; Q96IQ7; -.
DR BioGRID; 117119; 32.
DR IntAct; Q96IQ7; 25.
DR STRING; 9606.ENSP00000318684; -.
DR GlyGen; Q96IQ7; 2 sites.
DR iPTMnet; Q96IQ7; -.
DR PhosphoSitePlus; Q96IQ7; -.
DR BioMuta; VSIG2; -.
DR DMDM; 68053314; -.
DR jPOST; Q96IQ7; -.
DR MassIVE; Q96IQ7; -.
DR PaxDb; Q96IQ7; -.
DR PeptideAtlas; Q96IQ7; -.
DR PRIDE; Q96IQ7; -.
DR ProteomicsDB; 76843; -. [Q96IQ7-1]
DR ProteomicsDB; 76844; -. [Q96IQ7-2]
DR Antibodypedia; 32904; 250 antibodies from 24 providers.
DR DNASU; 23584; -.
DR Ensembl; ENST00000326621.10; ENSP00000318684.5; ENSG00000019102.12. [Q96IQ7-1]
DR Ensembl; ENST00000403470.1; ENSP00000385013.1; ENSG00000019102.12. [Q96IQ7-2]
DR GeneID; 23584; -.
DR KEGG; hsa:23584; -.
DR MANE-Select; ENST00000326621.10; ENSP00000318684.5; NM_014312.5; NP_055127.2.
DR UCSC; uc001qas.4; human. [Q96IQ7-1]
DR CTD; 23584; -.
DR DisGeNET; 23584; -.
DR GeneCards; VSIG2; -.
DR HGNC; HGNC:17149; VSIG2.
DR HPA; ENSG00000019102; Tissue enriched (stomach).
DR MIM; 606011; gene.
DR neXtProt; NX_Q96IQ7; -.
DR OpenTargets; ENSG00000019102; -.
DR PharmGKB; PA134937463; -.
DR VEuPathDB; HostDB:ENSG00000019102; -.
DR eggNOG; ENOG502RYI3; Eukaryota.
DR GeneTree; ENSGT00940000161544; -.
DR HOGENOM; CLU_040549_1_0_1; -.
DR InParanoid; Q96IQ7; -.
DR OMA; TPKETYG; -.
DR OrthoDB; 841952at2759; -.
DR PhylomeDB; Q96IQ7; -.
DR TreeFam; TF330875; -.
DR PathwayCommons; Q96IQ7; -.
DR SignaLink; Q96IQ7; -.
DR BioGRID-ORCS; 23584; 10 hits in 1065 CRISPR screens.
DR ChiTaRS; VSIG2; human.
DR GenomeRNAi; 23584; -.
DR Pharos; Q96IQ7; Tdark.
DR PRO; PR:Q96IQ7; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q96IQ7; protein.
DR Bgee; ENSG00000019102; Expressed in pancreatic ductal cell and 132 other tissues.
DR Genevisible; Q96IQ7; HS.
DR GO; GO:0005887; C:integral component of plasma membrane; TAS:ProtInc.
DR GO; GO:0016020; C:membrane; TAS:ProtInc.
DR GO; GO:0006629; P:lipid metabolic process; IEA:UniProtKB-KW.
DR Gene3D; 2.60.40.10; -; 2.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR013106; Ig_V-set.
DR InterPro; IPR042475; VSIG2.
DR PANTHER; PTHR45046; PTHR45046; 1.
DR Pfam; PF07686; V-set; 1.
DR SMART; SM00409; IG; 2.
DR SMART; SM00408; IGc2; 2.
DR SMART; SM00406; IGv; 1.
DR SUPFAM; SSF48726; SSF48726; 2.
DR PROSITE; PS50835; IG_LIKE; 2.
PE 1: Evidence at protein level;
KW Alternative splicing; Direct protein sequencing; Disulfide bond;
KW Glycoprotein; Immunoglobulin domain; Lipid metabolism; Membrane;
KW Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..23
FT /evidence="ECO:0000269|PubMed:15340161"
FT CHAIN 24..327
FT /note="V-set and immunoglobulin domain-containing protein
FT 2"
FT /id="PRO_0000015004"
FT TOPO_DOM 24..243
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 244..264
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 265..327
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 24..137
FT /note="Ig-like V-type"
FT DOMAIN 144..233
FT /note="Ig-like C2-type"
FT REGION 305..327
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 307..327
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 138
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 206
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 45..121
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 166..217
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT VAR_SEQ 285..327
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_014119"
FT CONFLICT 3
FT /note="E -> D (in Ref. 1; AAD17522)"
FT /evidence="ECO:0000305"
FT CONFLICT 21
FT /note="Missing (in Ref. 1; AAD17522)"
FT /evidence="ECO:0000305"
FT CONFLICT 54
FT /note="S -> T (in Ref. 1; AAD17522)"
FT /evidence="ECO:0000305"
FT CONFLICT 223
FT /note="M -> L (in Ref. 1; AAD17522)"
FT /evidence="ECO:0000305"
FT CONFLICT 243
FT /note="A -> T (in Ref. 1; AAD17522)"
FT /evidence="ECO:0000305"
FT CONFLICT 311
FT /note="Missing (in Ref. 1; AAD17522)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 327 AA; 34348 MW; CF395AC7EF951AC1 CRC64;
MAELPGPFLC GALLGFLCLS GLAVEVKVPT EPLSTPLGKT AELTCTYSTS VGDSFALEWS
FVQPGKPISE SHPILYFTNG HLYPTGSKSK RVSLLQNPPT VGVATLKLTD VHPSDTGTYL
CQVNNPPDFY TNGLGLINLT VLVPPSNPLC SQSGQTSVGG STALRCSSSE GAPKPVYNWV
RLGTFPTPSP GSMVQDEVSG QLILTNLSLT SSGTYRCVAT NQMGSASCEL TLSVTEPSQG
RVAGALIGVL LGVLLLSVAA FCLVRFQKER GKKPKETYGG SDLREDAIAP GISEHTCMRA
DSSKGFLERP SSASTVTTTK SKLPMVV
