VSIG2_MOUSE
ID VSIG2_MOUSE Reviewed; 328 AA.
AC Q9Z109; Q9CVA4; Q9D0T4;
DT 21-JUN-2005, integrated into UniProtKB/Swiss-Prot.
DT 21-JUN-2005, sequence version 2.
DT 03-AUG-2022, entry version 149.
DE RecName: Full=V-set and immunoglobulin domain-containing protein 2;
DE AltName: Full=Cortical thymocyte-like protein;
DE Short=CT-like protein;
DE Flags: Precursor;
GN Name=Vsig2; Synonyms=Ctm, Ctxl;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND TISSUE SPECIFICITY.
RX PubMed=9862345;
RX DOI=10.1002/(sici)1521-4141(199812)28:12<4094::aid-immu4094>3.0.co;2-2;
RA Chretien I., Marcuz A., Courtet M., Katevuo K., Vainio O., Heath J.K.,
RA White S.J., Du Pasquier L.;
RT "CTX, a Xenopus thymocyte receptor, defines a molecular family conserved
RT throughout vertebrates.";
RL Eur. J. Immunol. 28:4094-4104(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND NUCLEOTIDE SEQUENCE
RP [LARGE SCALE MRNA] OF 1-304 (ISOFORM 1).
RC STRAIN=C57BL/6J; TISSUE=Embryo, and Stomach;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9Z109-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9Z109-2; Sequence=VSP_014120;
CC -!- TISSUE SPECIFICITY: Expressed in the stomach, colon and prostate.
CC {ECO:0000269|PubMed:9862345}.
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DR EMBL; AF061024; AAD17524.1; -; Genomic_DNA.
DR EMBL; AK004478; BAB23323.1; -; mRNA.
DR EMBL; AK008920; BAB25968.1; -; mRNA.
DR CCDS; CCDS22980.1; -. [Q9Z109-1]
DR RefSeq; NP_065264.2; NM_020518.2. [Q9Z109-1]
DR AlphaFoldDB; Q9Z109; -.
DR SMR; Q9Z109; -.
DR STRING; 10090.ENSMUSP00000002008; -.
DR GlyGen; Q9Z109; 3 sites.
DR PhosphoSitePlus; Q9Z109; -.
DR MaxQB; Q9Z109; -.
DR PaxDb; Q9Z109; -.
DR PRIDE; Q9Z109; -.
DR ProteomicsDB; 275192; -. [Q9Z109-1]
DR ProteomicsDB; 275193; -. [Q9Z109-2]
DR Antibodypedia; 32904; 250 antibodies from 24 providers.
DR DNASU; 57276; -.
DR Ensembl; ENSMUST00000002008; ENSMUSP00000002008; ENSMUSG00000001943. [Q9Z109-1]
DR Ensembl; ENSMUST00000215271; ENSMUSP00000150115; ENSMUSG00000001943. [Q9Z109-2]
DR GeneID; 57276; -.
DR KEGG; mmu:57276; -.
DR UCSC; uc009ovb.1; mouse. [Q9Z109-1]
DR UCSC; uc012gra.1; mouse. [Q9Z109-2]
DR CTD; 23584; -.
DR MGI; MGI:1928009; Vsig2.
DR VEuPathDB; HostDB:ENSMUSG00000001943; -.
DR eggNOG; ENOG502RYI3; Eukaryota.
DR GeneTree; ENSGT00940000161544; -.
DR HOGENOM; CLU_040549_1_0_1; -.
DR InParanoid; Q9Z109; -.
DR OMA; TPKETYG; -.
DR OrthoDB; 841952at2759; -.
DR PhylomeDB; Q9Z109; -.
DR TreeFam; TF330875; -.
DR BioGRID-ORCS; 57276; 2 hits in 71 CRISPR screens.
DR PRO; PR:Q9Z109; -.
DR Proteomes; UP000000589; Chromosome 9.
DR RNAct; Q9Z109; protein.
DR Bgee; ENSMUSG00000001943; Expressed in pyloric antrum and 71 other tissues.
DR ExpressionAtlas; Q9Z109; baseline and differential.
DR Genevisible; Q9Z109; MM.
DR GO; GO:0005887; C:integral component of plasma membrane; ISA:MGI.
DR Gene3D; 2.60.40.10; -; 2.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR013106; Ig_V-set.
DR InterPro; IPR042475; VSIG2.
DR PANTHER; PTHR45046; PTHR45046; 1.
DR Pfam; PF07686; V-set; 1.
DR SMART; SM00409; IG; 2.
DR SMART; SM00408; IGc2; 2.
DR SMART; SM00406; IGv; 1.
DR SUPFAM; SSF48726; SSF48726; 2.
DR PROSITE; PS50835; IG_LIKE; 2.
PE 2: Evidence at transcript level;
KW Alternative splicing; Disulfide bond; Glycoprotein; Immunoglobulin domain;
KW Membrane; Reference proteome; Repeat; Signal; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..24
FT /evidence="ECO:0000250"
FT CHAIN 25..328
FT /note="V-set and immunoglobulin domain-containing protein
FT 2"
FT /id="PRO_0000015005"
FT TOPO_DOM 25..244
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 245..265
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 266..328
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 25..138
FT /note="Ig-like V-type"
FT DOMAIN 145..234
FT /note="Ig-like C2-type"
FT CARBOHYD 139
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 207
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 232
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 46..122
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 167..218
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT VAR_SEQ 22..101
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_014120"
FT CONFLICT 158
FT /note="S -> L (in Ref. 1; AAD17524)"
FT /evidence="ECO:0000305"
FT CONFLICT 184
FT /note="G -> C (in Ref. 1; AAD17524)"
FT /evidence="ECO:0000305"
FT CONFLICT 222
FT /note="N -> H (in Ref. 1; AAD17524)"
FT /evidence="ECO:0000305"
FT CONFLICT 240
FT /note="E -> D (in Ref. 1; AAD17524)"
FT /evidence="ECO:0000305"
FT CONFLICT 269..274
FT /note="KERKKE -> TEGTGA (in Ref. 1)"
FT /evidence="ECO:0000305"
FT CONFLICT 276
FT /note="K -> R (in Ref. 1; BAB23323)"
FT /evidence="ECO:0000305"
FT CONFLICT 296
FT /note="Q -> P (in Ref. 1; AAD17524)"
FT /evidence="ECO:0000305"
FT CONFLICT 316
FT /note="T -> A (in Ref. 1; AAD17524)"
FT /evidence="ECO:0000305"
FT CONFLICT 319
FT /note="T -> P (in Ref. 1; AAD17524)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 328 AA; 34514 MW; C57A121CC64E9617 CRC64;
MAWPLVGAFL CGHLLGFVCL SGLAVEVTVP TEPLSVPKGK TAELSCSYKT SVGDNFALEW
SFVQPGKPIS ASVPVLYFTN GHLYPTGSKA DRAILLHDPP TGGLATLKLT DLRPSDTGTY
LCNVNNPPDF YTNGLGLINL TVLVPPSHPL CSQSGQTSVG GSAALGCRSS EGAPKPVYNW
ERLGSSPTPP PGSMVQDEVS GQLILTNLSL TSSGTYRCVA SNQMGSASCE LNLSVTDSSE
GRVAGTLIGV LLGVLLLSVA AFCLIRFQKE RKKEPKETYG GSDLREDATA PGVFEQASMR
ADHSKELLEK SPCASTMTTT KSKLSMVV
