ID   VSIG8_HUMAN             Reviewed;         414 AA.
AC   P0DPA2; Q5VU13; Q5VU14;
DT   25-OCT-2017, integrated into UniProtKB/Swiss-Prot.
DT   25-OCT-2017, sequence version 1.
DT   03-AUG-2022, entry version 31.
DE   RecName: Full=V-set and immunoglobulin domain-containing protein 8;
DE   Flags: Precursor;
GN   Name=VSIG8 {ECO:0000312|HGNC:HGNC:32063}; Synonyms=C1orf204;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16710414; DOI=10.1038/nature04727;
RA   Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA   Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA   Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA   Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA   Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA   Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA   Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA   Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA   Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA   Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA   Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA   Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA   Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA   Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA   Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA   Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA   Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA   Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA   McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA   Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA   Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA   Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA   Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA   Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA   White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA   Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA   Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA   Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT   "The DNA sequence and biological annotation of human chromosome 1.";
RL   Nature 441:315-321(2006).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC       membrane protein {ECO:0000305}.
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DR   EMBL; AL590560; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC132893; AAI32894.1; -; mRNA.
DR   EMBL; BC132895; AAI32896.1; -; mRNA.
DR   CCDS; CCDS30913.1; -.
DR   RefSeq; NP_001013683.1; NM_001013661.1.
DR   AlphaFoldDB; P0DPA2; -.
DR   SMR; P0DPA2; -.
DR   IntAct; P0DPA2; 39.
DR   STRING; 9606.ENSP00000357080; -.
DR   iPTMnet; P0DPA2; -.
DR   PhosphoSitePlus; P0DPA2; -.
DR   BioMuta; VSIG8; -.
DR   MassIVE; P0DPA2; -.
DR   PeptideAtlas; P0DPA2; -.
DR   PRIDE; P0DPA2; -.
DR   Antibodypedia; 34887; 124 antibodies from 16 providers.
DR   DNASU; 391123; -.
DR   Ensembl; ENST00000368100.1; ENSP00000357080.1; ENSG00000243284.1.
DR   GeneID; 391123; -.
DR   KEGG; hsa:391123; -.
DR   MANE-Select; ENST00000368100.1; ENSP00000357080.1; NM_001013661.1; NP_001013683.1.
DR   CTD; 391123; -.
DR   DisGeNET; 391123; -.
DR   GeneCards; VSIG8; -.
DR   HGNC; HGNC:32063; VSIG8.
DR   HPA; ENSG00000243284; Tissue enhanced (lymphoid tissue, skin).
DR   neXtProt; NX_P0DPA2; -.
DR   OpenTargets; ENSG00000243284; -.
DR   VEuPathDB; HostDB:ENSG00000243284; -.
DR   eggNOG; ENOG502RXSJ; Eukaryota.
DR   GeneTree; ENSGT00940000161712; -.
DR   OMA; PAVPVCW; -.
DR   OrthoDB; 1077154at2759; -.
DR   PathwayCommons; P0DPA2; -.
DR   SignaLink; P0DPA2; -.
DR   Pharos; P0DPA2; Tdark.
DR   PRO; PR:P0DPA2; -.
DR   Proteomes; UP000005640; Chromosome 1.
DR   RNAct; P0DPA2; protein.
DR   Bgee; ENSG00000243284; Expressed in skin of leg and 50 other tissues.
DR   Genevisible; Q5VU13; HS.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; HDA:UniProtKB.
DR   Gene3D; 2.60.40.10; -; 2.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR003598; Ig_sub2.
DR   InterPro; IPR013106; Ig_V-set.
DR   Pfam; PF07686; V-set; 1.
DR   SMART; SM00409; IG; 2.
DR   SMART; SM00408; IGc2; 1.
DR   SMART; SM00406; IGv; 2.
DR   SUPFAM; SSF48726; SSF48726; 2.
DR   PROSITE; PS50835; IG_LIKE; 2.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Immunoglobulin domain; Membrane; Reference proteome;
KW   Repeat; Signal; Transmembrane; Transmembrane helix.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   CHAIN           22..414
FT                   /note="V-set and immunoglobulin domain-containing protein
FT                   8"
FT                   /id="PRO_0000313627"
FT   TOPO_DOM        22..263
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        264..284
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        285..414
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          22..141
FT                   /note="Ig-like V-type 1"
FT   DOMAIN          146..257
FT                   /note="Ig-like V-type 2"
FT   DISULFID        44..126
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT   DISULFID        167..239
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
SQ   SEQUENCE   414 AA;  43891 MW;  47BCD06CDF6AAF7B CRC64;
     MRVGGAFHLL LVCLSPALLS AVRINGDGQE VLYLAEGDNV RLGCPYVLDP EDYGPNGLDI
     EWMQVNSDPA HHRENVFLSY QDKRINHGSL PHLQQRVRFA ASDPSQYDAS INLMNLQVSD
     TATYECRVKK TTMATRKVIV TVQARPAVPM CWTEGHMTYG NDVVLKCYAS GGSQPLSYKW
     AKISGHHYPY RAGSYTSQHS YHSELSYQES FHSSINQGLN NGDLVLKDIS RADDGLYQCT
     VANNVGYSVC VVEVKVSDSR RIGVIIGIVL GSLLALGCLA VGIWGLVCCC CGGSGAGGAR
     GAFGYGNGGG VGGGACGDLA SEIREDAVAP GCKASGRGSR VTHLLGYPTQ NVSRSLRRKY
     APPPCGGPED VALAPCTAAA ACEAGPSPVY VKVKSAEPAD CAEGPVQCKN GLLV