VSIG8_MOUSE
ID VSIG8_MOUSE Reviewed; 417 AA.
AC Q6P3A4;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 15-JAN-2008, sequence version 2.
DT 03-AUG-2022, entry version 122.
DE RecName: Full=V-set and immunoglobulin domain-containing protein 8;
DE Flags: Precursor;
GN Name=Vsig8;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Skin;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Mammary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q6P3A4-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6P3A4-2; Sequence=VSP_030071;
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DR EMBL; AK037228; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; BC064106; AAH64106.1; -; mRNA.
DR CCDS; CCDS15516.1; -. [Q6P3A4-1]
DR RefSeq; NP_808391.2; NM_177723.4. [Q6P3A4-1]
DR AlphaFoldDB; Q6P3A4; -.
DR SMR; Q6P3A4; -.
DR BioGRID; 232259; 1.
DR IntAct; Q6P3A4; 1.
DR STRING; 10090.ENSMUSP00000058008; -.
DR iPTMnet; Q6P3A4; -.
DR PhosphoSitePlus; Q6P3A4; -.
DR MaxQB; Q6P3A4; -.
DR PaxDb; Q6P3A4; -.
DR PRIDE; Q6P3A4; -.
DR ProteomicsDB; 297548; -. [Q6P3A4-1]
DR ProteomicsDB; 297549; -. [Q6P3A4-2]
DR Antibodypedia; 34887; 124 antibodies from 16 providers.
DR DNASU; 240916; -.
DR Ensembl; ENSMUST00000061835; ENSMUSP00000058008; ENSMUSG00000049598. [Q6P3A4-1]
DR Ensembl; ENSMUST00000177086; ENSMUSP00000134997; ENSMUSG00000049598. [Q6P3A4-2]
DR GeneID; 240916; -.
DR KEGG; mmu:240916; -.
DR UCSC; uc007dqs.2; mouse. [Q6P3A4-1]
DR CTD; 391123; -.
DR MGI; MGI:3642995; Vsig8.
DR VEuPathDB; HostDB:ENSMUSG00000049598; -.
DR eggNOG; ENOG502RXSJ; Eukaryota.
DR GeneTree; ENSGT00940000161712; -.
DR HOGENOM; CLU_040549_0_2_1; -.
DR InParanoid; Q6P3A4; -.
DR OMA; PAVPVCW; -.
DR OrthoDB; 1077154at2759; -.
DR PhylomeDB; Q6P3A4; -.
DR TreeFam; TF330875; -.
DR BioGRID-ORCS; 240916; 1 hit in 70 CRISPR screens.
DR PRO; PR:Q6P3A4; -.
DR Proteomes; UP000000589; Chromosome 1.
DR RNAct; Q6P3A4; protein.
DR Bgee; ENSMUSG00000049598; Expressed in lip and 33 other tissues.
DR Genevisible; Q6P3A4; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR Gene3D; 2.60.40.10; -; 2.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR013106; Ig_V-set.
DR Pfam; PF07686; V-set; 1.
DR SMART; SM00409; IG; 2.
DR SMART; SM00408; IGc2; 1.
DR SMART; SM00406; IGv; 1.
DR SUPFAM; SSF48726; SSF48726; 2.
DR PROSITE; PS50835; IG_LIKE; 2.
PE 2: Evidence at transcript level;
KW Alternative splicing; Disulfide bond; Immunoglobulin domain; Membrane;
KW Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT CHAIN 22..417
FT /note="V-set and immunoglobulin domain-containing protein
FT 8"
FT /id="PRO_0000313628"
FT TOPO_DOM 22..262
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 263..283
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 284..417
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 22..140
FT /note="Ig-like V-type 1"
FT DOMAIN 145..256
FT /note="Ig-like V-type 2"
FT DISULFID 44..125
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 166..238
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT VAR_SEQ 1..112
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_030071"
FT CONFLICT 348
FT /note="T -> A (in Ref. 1; AK037228)"
FT /evidence="ECO:0000305"
FT CONFLICT 355
FT /note="L -> R (in Ref. 1; AK037228)"
FT /evidence="ECO:0000305"
FT CONFLICT 369
FT /note="D -> H (in Ref. 1; AK037228)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 417 AA; 44187 MW; 14AFF349F1B31821 CRC64;
MGVRGALHLL LVCLSPALLS AVRINGDGQE VMYLAEGDNV RLGCPYLLDP EDLGTNSLDI
EWMQVNSEPS HRENVFLTYQ DKRIGHGNLP HLQQRVRFAA SDPSQYDASI NLMNLQVSDT
ATYECRVKKT TMATRKVIVT VQARPAVPMC WTEGHMSKGN DVVLKCFANG GSQPLSYKWA
KISGHSHPYR AGAYHSQHSF HSELSYQESF HSTINQGLGN GDLLLKGINA DDDGLYQCTV
ANHVGYSVCV VEVKVSDSQR VGMIVGAVLG SLLMLACLAL GIWGLICCCC GGGGAGGARG
AFGYGVGGGV GGGACGDLAS EIRVDAEAPG CKASGRGSRV THLLGYPTQN VSRSLRRKYA
PPPCGGPEDV ALVPRTASAS CEAGPSPVYI KVKSAEPADC ADCAQVEQRS CKDGLLV
