ID   VSM0_TRYBB              Reviewed;          72 AA.
AC   P07209;
DT   01-APR-1988, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1988, sequence version 1.
DT   25-MAY-2022, entry version 66.
DE   RecName: Full=Variant surface glycoprotein MITAT 1.1000BC;
DE            Short=VSG;
DE   Flags: Precursor; Fragment;
OS   Trypanosoma brucei brucei.
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Trypanosoma.
OX   NCBI_TaxID=5702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=6306255; DOI=10.1016/s0022-2836(83)80034-5;
RA   Liu A.Y.C., van der Ploeg L.H.T., Rijsewijk F.A.M., Borst P.;
RT   "The transposition unit of variant surface glycoprotein gene 118 of
RT   Trypanosoma brucei. Presence of repeated elements at its border and absence
RT   of promoter-associated sequences.";
RL   J. Mol. Biol. 167:57-75(1983).
CC   -!- FUNCTION: VSG forms a coat on the surface of the parasite. The
CC       trypanosome evades the immune response of the host by expressing a
CC       series of antigenically distinct VSGs from an estimated 1000 VSG genes.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor, GPI-anchor. Note=A
CC       soluble form is released from ruptured cells by the action of a PI-PLC.
CC       {ECO:0000250}.
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DR   EMBL; V01550; CAA24790.1; -; Genomic_DNA.
DR   PIR; S07254; S07254.
DR   AlphaFoldDB; P07209; -.
DR   GO; GO:0031225; C:anchored component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR019609; Variant_surf_glycoprt_trypan_C.
DR   Pfam; PF10659; Trypan_glycop_C; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Glycoprotein; GPI-anchor; Lipoprotein; Membrane;
KW   Trypanosomiasis.
FT   CHAIN           <1..50
FT                   /note="Variant surface glycoprotein MITAT 1.1000BC"
FT                   /id="PRO_0000036429"
FT   PROPEP          51..72
FT                   /note="Removed in mature form"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000036430"
FT   LIPID           50
FT                   /note="GPI-anchor amidated aspartate"
FT                   /evidence="ECO:0000255"
FT   NON_TER         1
SQ   SEQUENCE   72 AA;  7937 MW;  AEEA33AF2E2242C3 CRC64;
     AEKTAQACEE AEKATKCARQ GTGKTGDKHN CAFRKGKDGK EEPEKEKCCD GSFLVNKKFA
     LMVYDFVSLL AF