VSP1_BORHE
ID VSP1_BORHE Reviewed; 214 AA.
AC Q45208; Q53329;
DT 27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 25-MAY-2022, entry version 70.
DE RecName: Full=Variable small protein 1 {ECO:0000303|PubMed:9453591};
DE Flags: Precursor;
GN Name=vsp1 {ECO:0000303|PubMed:9453591};
GN Synonyms=vmp1 {ECO:0000303|PubMed:8087853};
OS Borrelia hermsii.
OG Plasmid {ECO:0000312|EMBL:AAB27190.1}.
OC Bacteria; Spirochaetes; Spirochaetales; Borreliaceae; Borrelia.
OX NCBI_TaxID=140;
RN [1] {ECO:0000312|EMBL:AAB27190.1}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 35209 / HS1;
RX PubMed=8515101; DOI=10.1093/infdis/168.1.143;
RA Cadavid D., Bundoc V., Barbour A.G.;
RT "Experimental infection of the mouse brain by a relapsing fever Borrelia
RT species: a molecular analysis.";
RL J. Infect. Dis. 168:143-151(1993).
RN [2] {ECO:0000312|EMBL:AAA59217.1}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 35209 / HS1;
RX PubMed=8087853; DOI=10.1016/s0092-8674(94)90642-4;
RA Restrepo B.I., Barbour A.G.;
RT "Antigen diversity in the bacterium B. hermsii through 'somatic' mutations
RT in rearranged vmp genes.";
RL Cell 78:867-876(1994).
RN [3] {ECO:0000305}
RP NOMENCLATURE.
RX PubMed=9453591; DOI=10.1128/iai.66.2.432-440.1998;
RA Hinnebusch B.J., Barbour A.G., Restrepo B.I., Schwan T.G.;
RT "Population structure of the relapsing fever spirochete Borrelia hermsii as
RT indicated by polymorphism of two multigene families that encode immunogenic
RT outer surface lipoproteins.";
RL Infect. Immun. 66:432-440(1998).
CC -!- FUNCTION: The Vlp and Vsp proteins are antigenically distinct proteins,
CC only one vlp or vsp gene is transcriptionally active at any one time.
CC Switching between these genes is a mechanism of host immune response
CC evasion. {ECO:0000250|UniProtKB:P21875}.
CC -!- SUBCELLULAR LOCATION: Cell outer membrane
CC {ECO:0000250|UniProtKB:P21875}; Lipid-anchor.
CC -!- MISCELLANEOUS: Genes for both Vlp and Vsp families are on (usually)
CC unnamed linear plasmids in B.hermsii HS1. {ECO:0000305|PubMed:9453591}.
CC -!- SIMILARITY: Belongs to the variable small protein (Vsp) family.
CC {ECO:0000269|PubMed:9453591}.
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DR EMBL; S62751; AAB27190.1; -; Genomic_DNA.
DR EMBL; L33870; AAA59217.1; -; Genomic_DNA.
DR PIR; I40301; I40301.
DR RefSeq; WP_015633341.1; NZ_CP014810.1.
DR AlphaFoldDB; Q45208; -.
DR SMR; Q45208; -.
DR GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR Gene3D; 1.20.120.240; -; 1.
DR InterPro; IPR001800; Lipoprotein_OspC.
DR InterPro; IPR036437; OspC-like_sf.
DR Pfam; PF01441; Lipoprotein_6; 1.
DR SUPFAM; SSF63515; SSF63515; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 3: Inferred from homology;
KW Cell outer membrane; Lipoprotein; Membrane; Palmitate; Plasmid; Signal.
FT SIGNAL 1..18
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT CHAIN 19..214
FT /note="Variable small protein 1"
FT /evidence="ECO:0000255"
FT /id="PRO_0000244509"
FT LIPID 19
FT /note="N-palmitoyl cysteine"
FT /evidence="ECO:0000255, ECO:0000305"
FT LIPID 19
FT /note="S-diacylglycerol cysteine"
FT /evidence="ECO:0000255, ECO:0000305"
FT CONFLICT 62
FT /note="H -> Q (in Ref. 1; AAB27190)"
FT /evidence="ECO:0000305"
FT CONFLICT 96
FT /note="L -> I (in Ref. 1; AAB27190)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 214 AA; 22279 MW; FFAD67844AA92782 CRC64;
MRKRISAIIM TLFMVFMSCN NGGPELKSDE VAKSDGTVLD LAKISAKIKE ASAFAASVKE
VHTLVKSVDT LAGAIGKKIK SDGKFDAMAG KNGSLLAGAY NVALDINSKL TVLDGKAGLS
SLLKAKVTAA KTSGESFSNK LKTEHTDLGK EEASDDNAKA ALLVTNATKN KGVTELEALN
TAVDALLKAA EGEVEAAIKE LTAPVKVEKP SQNN
