ID   VSP1_SCOSU              Reviewed;         286 AA.
AC   O96900;
DT   20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   03-AUG-2022, entry version 64.
DE   RecName: Full=Serine protease SSP1;
DE            EC=3.4.21.-;
DE   Flags: Precursor; Fragment;
OS   Scolopendra subspinipes (Vietnamese centipede).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Myriapoda; Chilopoda;
OC   Pleurostigmophora; Scolopendromorpha; Scolopendridae; Scolopendra.
OX   NCBI_TaxID=55038;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Sohn Y.-D., Park D.-H.;
RT   "A novel serine protease from a Korean centipede Scolopendra.";
RL   Submitted (NOV-1996) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the peptidase S1 family. {ECO:0000255|PROSITE-
CC       ProRule:PRU00274}.
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DR   EMBL; U79522; AAD09224.1; -; mRNA.
DR   MEROPS; S01.A64; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   CDD; cd00190; Tryp_SPc; 1.
DR   Gene3D; 2.40.10.10; -; 1.
DR   InterPro; IPR009003; Peptidase_S1_PA.
DR   InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin.
DR   InterPro; IPR001314; Peptidase_S1A.
DR   InterPro; IPR001254; Trypsin_dom.
DR   InterPro; IPR018114; TRYPSIN_HIS.
DR   InterPro; IPR033116; TRYPSIN_SER.
DR   Pfam; PF00089; Trypsin; 1.
DR   PRINTS; PR00722; CHYMOTRYPSIN.
DR   SMART; SM00020; Tryp_SPc; 1.
DR   SUPFAM; SSF50494; SSF50494; 1.
DR   PROSITE; PS50240; TRYPSIN_DOM; 1.
DR   PROSITE; PS00134; TRYPSIN_HIS; 1.
DR   PROSITE; PS00135; TRYPSIN_SER; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Hydrolase; Protease; Secreted; Serine protease; Signal.
FT   SIGNAL          <1..18
FT                   /evidence="ECO:0000255"
FT   PROPEP          19..35
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000359442"
FT   CHAIN           36..286
FT                   /note="Serine protease SSP1"
FT                   /id="PRO_0000359443"
FT   DOMAIN          36..273
FT                   /note="Peptidase S1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00274"
FT   ACT_SITE        80
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        131
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        223
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000250"
FT   DISULFID        65..81
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00274"
FT   DISULFID        196..206
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00274"
FT   NON_TER         1
SQ   SEQUENCE   286 AA;  31146 MW;  63F6FDC959D0EDB1 CRC64;
     GTRKTGILLL FLVAATTSFK LPKNESPVLI SDDDRIIGGT QAYPNAYPFM VRLTTIWQNG
     WGGSCGRSLI XSQWVLTAAH CVYNLEKSMY WERVIVYLGD HYSQVTDAHE QVKEAADVIV
     HENYISSGSN DVALIKLKTP ANINSYVKPG CLNSKSNDFI GQDATAAGWG LTSTIGNTIS
     NVLMEATLPI VAPKNCPIIN PPTMICTGFK REVGQDTVFK GDSGGPLFLS KNGFTILGVA
     SFVTLDNSYP QKVTSAVFTK VSAHLSWIQE NTKATDLWCA KNNHHS