ID   VSP6_BORHE              Reviewed;         215 AA.
AC   Q45214; Q3S4W6;
DT   27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 66.
DE   RecName: Full=Variable small protein 6 {ECO:0000303|PubMed:9453591};
DE   Flags: Precursor;
GN   Name=vsp6 {ECO:0000303|PubMed:9453591, ECO:0000312|EMBL:AAZ94628.1};
GN   Synonyms=vmp6 {ECO:0000303|PubMed:8087853};
OS   Borrelia hermsii.
OG   Plasmid lp32-1 {ECO:0000312|EMBL:AAZ94628.1}.
OC   Bacteria; Spirochaetes; Spirochaetales; Borreliaceae; Borrelia.
OX   NCBI_TaxID=140;
RN   [1] {ECO:0000312|EMBL:AAA59224.1}
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 35209 / HS1;
RX   PubMed=8087853; DOI=10.1016/s0092-8674(94)90642-4;
RA   Restrepo B.I., Barbour A.G.;
RT   "Antigen diversity in the bacterium B. hermsii through 'somatic' mutations
RT   in rearranged vmp genes.";
RL   Cell 78:867-876(1994).
RN   [2] {ECO:0000312|EMBL:AAZ94628.1}
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 35209 / HS1; PLASMID=lp32-1;
RA   Dai Q., Restrepo B.I., Porcella S.F., Schwan T.G., Barbour A.G.;
RT   "Antigenic variation during relapsing fever through recombination between
RT   extragenic sequences.";
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000305}
RP   NOMENCLATURE.
RX   PubMed=9453591; DOI=10.1128/iai.66.2.432-440.1998;
RA   Hinnebusch B.J., Barbour A.G., Restrepo B.I., Schwan T.G.;
RT   "Population structure of the relapsing fever spirochete Borrelia hermsii as
RT   indicated by polymorphism of two multigene families that encode immunogenic
RT   outer surface lipoproteins.";
RL   Infect. Immun. 66:432-440(1998).
CC   -!- FUNCTION: The Vlp and Vsp proteins are antigenically distinct proteins,
CC       only one vlp or vsp gene is transcriptionally active at any one time.
CC       Switching between these genes is a mechanism of host immune response
CC       evasion. {ECO:0000250|UniProtKB:P21875}.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane
CC       {ECO:0000250|UniProtKB:P21875}; Lipid-anchor.
CC   -!- MISCELLANEOUS: Genes for both Vlp and Vsp families are on (usually)
CC       unnamed linear plasmids in B.hermsii HS1. {ECO:0000305|PubMed:9453591}.
CC   -!- SIMILARITY: Belongs to the variable small protein (Vsp) family.
CC       {ECO:0000269|PubMed:9453591}.
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DR   EMBL; L33898; AAA59224.1; -; Genomic_DNA.
DR   EMBL; DQ166207; AAZ94628.1; -; Genomic_DNA.
DR   PIR; I40309; I40309.
DR   AlphaFoldDB; Q45214; -.
DR   SMR; Q45214; -.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   Gene3D; 1.20.120.240; -; 1.
DR   InterPro; IPR001800; Lipoprotein_OspC.
DR   InterPro; IPR036437; OspC-like_sf.
DR   Pfam; PF01441; Lipoprotein_6; 1.
DR   SUPFAM; SSF63515; SSF63515; 1.
DR   PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE   3: Inferred from homology;
KW   Cell outer membrane; Lipoprotein; Membrane; Palmitate; Plasmid; Signal.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT   CHAIN           19..215
FT                   /note="Variable small protein 6"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000244511"
FT   LIPID           19
FT                   /note="N-palmitoyl cysteine"
FT                   /evidence="ECO:0000255, ECO:0000305"
FT   LIPID           19
FT                   /note="S-diacylglycerol cysteine"
FT                   /evidence="ECO:0000255, ECO:0000305"
FT   CONFLICT        17
FT                   /note="M -> T (in Ref. 2; AAZ94628)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        44
FT                   /note="V -> I (in Ref. 2; AAZ94628)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        56
FT                   /note="A -> E (in Ref. 2; AAZ94628)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        68
FT                   /note="V -> I (in Ref. 2; AAZ94628)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        125
FT                   /note="R -> K (in Ref. 2; AAZ94628)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        148
FT                   /note="S -> T (in Ref. 2; AAZ94628)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        173..178
FT                   /note="VRKSLF -> GKEELI (in Ref. 2; AAZ94628)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   215 AA;  22728 MW;  DD00E42ACF0BC6B4 CRC64;
     MRKRISAIIM TLFMVFMSCN NGGPELKSDE VAKSDGTVLD LAKVSKKIKE ASAFAASVKE
     VETLVKSVDE LAKAIGKKIK NDDDGFDTEA NKNGSLLAGT LQLMFAVGTK LESLEKIAGI
     SDEVRGKVIV VKTENTALIT KLKGGDASLG KNDASDSDAK NAIDKSDVTG GKVRKSLFKL
     NTAVDALLKA AEGEVEAAIK ELTAPVKVEK PSQNN