ID   VSPDV_BOTJR             Reviewed;          10 AA.
AC   P0DJE8;
DT   21-MAR-2012, integrated into UniProtKB/Swiss-Prot.
DT   21-MAR-2012, sequence version 1.
DT   03-AUG-2022, entry version 20.
DE   RecName: Full=Thrombin-like enzyme D-V;
DE            Short=SVTLE D-V;
DE            EC=3.4.21.-;
DE   AltName: Full=Clotting factor;
DE   AltName: Full=Fibrinogen-clotting enzyme;
DE   AltName: Full=Snake venom serine protease;
DE            Short=SVSP;
DE   Flags: Fragment;
OS   Bothrops jararacussu (Jararacussu).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC   Serpentes; Colubroidea; Viperidae; Crotalinae; Bothrops.
OX   NCBI_TaxID=8726;
RN   [1]
RP   PROTEIN SEQUENCE, FUNCTION, AND ACTIVITY REGULATION.
RC   TISSUE=Venom;
RX   PubMed=9248003; DOI=10.1016/s0041-0101(96)00222-x;
RA   Andriao-Escarso S.H., Sampaio S.V., Cunha O.A., Marangoni S., Oliveira B.,
RA   Giglio J.R.;
RT   "Isolation and characterization of a new clotting factor from Bothrops
RT   jararacussu (jararacucu) venom.";
RL   Toxicon 35:1043-1052(1997).
CC   -!- FUNCTION: Thrombin-like enzyme that induces quick formation of fibrin
CC       clots. Only degrades the Aalpha-chain of fibrinogen (FGA).
CC       {ECO:0000269|PubMed:9248003}.
CC   -!- ACTIVITY REGULATION: Is not inhibited by aprotinin.
CC       {ECO:0000269|PubMed:9248003}.
CC   -!- SUBUNIT: Monomer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC   -!- PTM: Glycosylated.
CC   -!- SIMILARITY: Belongs to the peptidase S1 family. Snake venom subfamily.
CC       {ECO:0000255|PROSITE-ProRule:PRU00274}.
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DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0008236; F:serine-type peptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Blood coagulation cascade activating toxin; Direct protein sequencing;
KW   Disulfide bond; Glycoprotein; Hemostasis impairing toxin; Hydrolase;
KW   Protease; Secreted; Serine protease; Toxin.
FT   CHAIN           1..>10
FT                   /note="Thrombin-like enzyme D-V"
FT                   /id="PRO_0000416018"
FT   DOMAIN          1..>10
FT                   /note="Peptidase S1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00274"
FT   DISULFID        7..?
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00274"
FT   NON_TER         10
SQ   SEQUENCE   10 AA;  1052 MW;  3D854A4EB44AADD8 CRC64;
     VVGADNCNFN