ID   VSPE2_CROAT             Reviewed;          25 AA.
AC   Q7LZF6;
DT   03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   15-DEC-2003, sequence version 1.
DT   03-AUG-2022, entry version 32.
DE   RecName: Full=Kallikrein-like EII;
DE            EC=3.4.21.-;
DE   Flags: Fragment;
OS   Crotalus atrox (Western diamondback rattlesnake).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC   Serpentes; Colubroidea; Viperidae; Crotalinae; Crotalus.
OX   NCBI_TaxID=8730;
RN   [1]
RP   PROTEIN SEQUENCE, AND FUNCTION.
RC   TISSUE=Venom;
RX   PubMed=6355088; DOI=10.1016/s0021-9258(17)44214-1;
RA   Bjarnason J.B., Barish A., Direnzo G.S., Campbell R., Fox J.W.;
RT   "Kallikrein-like enzymes from Crotalus atrox venom.";
RL   J. Biol. Chem. 258:12566-12573(1983).
CC   -!- FUNCTION: Cleaves a kininogen analog to release bradykinin.
CC       {ECO:0000269|PubMed:6355088}.
CC   -!- ACTIVITY REGULATION: Inhibited by aprotinin and PMSF, but not by EDTA.
CC   -!- SUBUNIT: Monomer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC   -!- MISCELLANEOUS: Does not have plasmin or fibrinolytic activity.
CC       {ECO:0000305|PubMed:6355088}.
CC   -!- SIMILARITY: Belongs to the peptidase S1 family. Snake venom subfamily.
CC       {ECO:0000255|PROSITE-ProRule:PRU00274}.
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DR   PIR; B20596; B20596.
DR   AlphaFoldDB; Q7LZF6; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0008236; F:serine-type peptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Hydrolase; Protease; Secreted; Serine protease;
KW   Toxin.
FT   CHAIN           1..>25
FT                   /note="Kallikrein-like EII"
FT                   /id="PRO_0000407588"
FT   DOMAIN          1..>25
FT                   /note="Peptidase S1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00274"
FT   NON_TER         25
SQ   SEQUENCE   25 AA;  2881 MW;  3F3C8B5ABA619B6E CRC64;
     HVGGDECNIN EHRSLVAIFV FTEFF