ID   VSPR_VIBCH              Reviewed;         187 AA.
AC   Q9KVG9;
DT   16-OCT-2013, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 62.
DE   RecName: Full=Transcriptional regulator VspR;
DE   AltName: Full=V.cholerae 7th pandemic regulator;
DE   AltName: Full=VSP-1 transcription factor VspR;
GN   Name=vspR; OrderedLocusNames=VC_0177;
OS   Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC   Vibrio.
OX   NCBI_TaxID=243277;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 39315 / El Tor Inaba N16961;
RX   PubMed=10952301; DOI=10.1038/35020000;
RA   Heidelberg J.F., Eisen J.A., Nelson W.C., Clayton R.A., Gwinn M.L.,
RA   Dodson R.J., Haft D.H., Hickey E.K., Peterson J.D., Umayam L.A., Gill S.R.,
RA   Nelson K.E., Read T.D., Tettelin H., Richardson D.L., Ermolaeva M.D.,
RA   Vamathevan J.J., Bass S., Qin H., Dragoi I., Sellers P., McDonald L.A.,
RA   Utterback T.R., Fleischmann R.D., Nierman W.C., White O., Salzberg S.L.,
RA   Smith H.O., Colwell R.R., Mekalanos J.J., Venter J.C., Fraser C.M.;
RT   "DNA sequence of both chromosomes of the cholera pathogen Vibrio
RT   cholerae.";
RL   Nature 406:477-483(2000).
RN   [2]
RP   FUNCTION, GENE NAME, AND INDUCTION.
RC   STRAIN=ATCC 55056 / El Tor Ogawa E7946, and El Tor C6706;
RX   PubMed=22500802; DOI=10.1016/j.cell.2012.01.053;
RA   Davies B.W., Bogard R.W., Young T.S., Mekalanos J.J.;
RT   "Coordinated regulation of accessory genetic elements produces cyclic di-
RT   nucleotides for V. cholerae virulence.";
RL   Cell 149:358-370(2012).
CC   -!- FUNCTION: Represses the transcription of several genes encoded within
CC       the Vibrio 7th pandemic island-1 (VSP-1), including dncV, VC_0176,
CC       VC_0178 and VC_0180. {ECO:0000269|PubMed:22500802}.
CC   -!- INDUCTION: Expression is repressed by the TCP island-encoded sRNA TarB.
CC       {ECO:0000269|PubMed:22500802}.
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DR   EMBL; AE003852; AAF93353.1; -; Genomic_DNA.
DR   PIR; D82354; D82354.
DR   RefSeq; NP_229834.1; NC_002505.1.
DR   RefSeq; WP_001901324.1; NZ_LT906614.1.
DR   AlphaFoldDB; Q9KVG9; -.
DR   SMR; Q9KVG9; -.
DR   STRING; 243277.VC_0177; -.
DR   PRIDE; Q9KVG9; -.
DR   DNASU; 2614269; -.
DR   EnsemblBacteria; AAF93353; AAF93353; VC_0177.
DR   GeneID; 57738916; -.
DR   KEGG; vch:VC_0177; -.
DR   eggNOG; ENOG5032UH6; Bacteria.
DR   HOGENOM; CLU_122379_1_0_6; -.
DR   OMA; YQSFPEM; -.
DR   BioCyc; VCHO:VC0177-MON; -.
DR   Proteomes; UP000000584; Chromosome 1.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IMP:UniProtKB.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IMP:UniProtKB.
PE   2: Evidence at transcript level;
KW   DNA-binding; Reference proteome; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..187
FT                   /note="Transcriptional regulator VspR"
FT                   /id="PRO_0000423946"
SQ   SEQUENCE   187 AA;  21757 MW;  4CD60CB42D842AD1 CRC64;
     MRRSMKISAE MYKLLIERTL DGFSVIELRD EFIVIKDSLI DPDEAYKKVY RQILRFIKKG
     WLNGEGSGRQ KRYFQTDTFK ALHAEPKSEN VDIEIVLNQD YSVLVSERNQ YKGELEIVLG
     EIDEYQSLNI RFPELEPKLI TLLDEAKERS ACLLGKVNGL TNVLKVLSGQ KIVHQKFKTK
     ALLFERT